tag:blogger.com,1999:blog-39733898282326328212024-03-14T06:03:48.979-07:00ARKADMEDLABYour care at heartUnknownnoreply@blogger.comBlogger13125tag:blogger.com,1999:blog-3973389828232632821.post-52151383331034136192020-09-12T12:07:00.002-07:002020-09-12T12:07:26.941-07:00Sample of Hepatitis B Profile Results Showing Late Incubation Period of Hepatitis B. Virus Infection.<p dir="ltr"><span style="font-family: times;"><span>ARKAD MEDLAB SOLUTIONS </span></span></p><p dir="ltr"><span style="font-family: times;"><span>P.O BOX MP 1229, ACCRA</span></span></p><p dir="ltr"><span style="font-family: times;"><span>CONTACT: arkadmedlabsolutions@gmail.com </span></span></p><p dir="ltr"><span style="font-family: times;"><span> </span><u><span><b><u><span>IMMUNOCHEMISTRY REPORT</span></u></b></span></u><br />
<span> </span><span><b><br /></b></span></span></p><p dir="ltr"><span style="font-family: times;"><span><b>Hepatitis B Profi</b></span><b><span>le</span></b><span><b><span> </span></b></span><br />
<span><br /></span></span></p><p dir="ltr"><span style="font-family: times;"><span>Name: </span><span> </span><span> Age</span><span>:</span><span> 51</span><span>yrs</span><span> </span><span> </span><span> </span><span>Sex: F</span><span>emale</span><span> </span><span> </span><span> Lab no: 4935</span><span> </span><span> </span></span></p>
<p dir="ltr"><span style="font-family: times;"><span>Parameters </span><span>Results</span><br />
<span>HBs</span><span> </span><span>Ag……………………………</span><span><b>Positive</b></span><br />
<span>HBs</span><span> </span><span>Ab……………………………</span><b><span>Negative</span></b><br />
<span>*</span><span>HBeAg………………………….</span><span> </span><span><b>Posi</b></span><b><span>tive </span></b><br />
<span>*</span><span>HBeAb</span><span>………………………….</span><span> </span><span><b>Negat</b></span><span><b>i</b></span><b><span>ve</span></b><br />
<span>*</span><span>HBcAb</span><span>…………………………..</span><span> </span><span> </span><span><b>Negative</b></span><br />
<span>Hepatitis B core </span><span>Ig</span><span> </span><span>M……………Non Reactive</span><span> </span><span>(Negative)</span></span></p>
<p dir="ltr"><span style="font-family: times;"><span><b>Comments</b></span><b><span>:</span></b><span> Results suggestive</span><span> of </span><b><i><span>Late incubation period</span></i></b><span> of HBV infection</span><span><span> </span></span><br />
<span> </span></span><br />
</p><p dir="ltr"><span style="font-size: 22px;"> </span></p>Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-3973389828232632821.post-86419837309671391952020-09-05T08:45:00.006-07:002020-09-05T09:10:38.219-07:00SEMEN ANALYSIS : TEST FOR MALE FERTILITY<div style="text-align: left;"> </div><p dir="ltr"><u><span><b>IMMUNOLOGY AND CELL BIOLOGY DEPARTMENT</b></span></u><br /><br /><b><u>ARKAD MEDLAB SOLUTIONS</u></b></p><p dir="ltr"><b><u><br /></u></b>
<u><span><span><b>STANDARD OPERATING PROCEDURE FOR SEMEN ANALYSIS</b></span></span></u></p>
<p dir="ltr"><b><span>OBJECTIVES</span></b><br />
<span>• </span><span> </span><span><span>To evaluate male fertility in an infertile marriage.</span></span></p><p dir="ltr"><br />
<span>• </span><span><span>To substantiate the effectiveness of vasectomy</span></span></p><p dir="ltr"><br />
<span>• </span><span><span>To detect semen on the body or cloth of a suspected rape victim at the crime scene.</span></span></p><p dir="ltr"><br />
<span>• </span><span><span>To identify blood group substances to exonerate or incriminate a criminal suspect.</span></span></p><p dir="ltr"><br />
<span>• </span><span><span>To rule out paternity on grounds of complete sterility.</span></span></p><p dir="ltr"><br />
<span><b><span>PATIENTS’ PREPARATION</span></b></span><br />
<span>• </span><span>Explain the procedure to the patient</span><br />
<span>• </span><span>Instruct the patients to abstain from sexual activity for 2 to 3 days before collecting the specimen.</span><br />
<span>• </span><span>Give the patient the proper container for the sperm collection.</span><br />
<span>• </span><span>Instruct the patient to avoid alcoholic beverages for several days before the collection.</span></p>
<p dir="ltr"><b><span>SAMPLE COLLECTION AND DELIVERY</span></b><br />
<span>• </span><span>Ideally the sample should be collected in the privacy of a room near the laboratory. If not, it should be delivered to the laboratory within 1 hour after collection.</span></p>
<p dir="ltr"><span>• </span><span>The sample should be collected after a minimum of 48 hours and no longer than 7days of sexual abstinence. The name of the man, period of abstainence, date and time of collection should be recorded. When the duration of abstinence is more than 7 days, sperm motility, and concentration may be decline; if the duration of abstinence is 48hrs, sperm concentration may be reduced.</span></p>
<p dir="ltr"><span>• </span><span>The sample should be obtained by masturbation and ejaculated into a clean, wide –mouthed glass or plastic container. The container should be warm to minimize the risk of cold shock. In cases in which masturbation is not possible or against individual’s values, the specimen can be collected in a non-spermicidal condom. Coitus interruptus is not acceptable as a means of collection because it is possible that the first portion of the ejaculate, which contains the highest concentration of spermatozoa, will be lost.</span><br /><br /><br /></p>
<p dir="ltr"><span><b>LABORATORY </b></span><span><b>PROCEDURE</b></span></p>
<p dir="ltr"><b><span>MACROSCOPIC EVALUATION</span></b></p>
<p dir="ltr"><b><span>• </span></b><b><span>Appearance </span></b></p>
<p dir="ltr"><span>o </span><span>A normal sample has a grey –opalescent, is homogenous and liquefies within 60 mins at room temperature. The sample may appear clear if the sperm concentration is too low or brown when red blood cells are present(haematosperia).</span></p>
<p dir="ltr"><b><span>• </span></b><b><span>Consistency (viscosity)</span></b></p>
<p dir="ltr"><span>o </span><span>It can be estimated by gentle aspiration into a 5ml pipette and then allowing the semen to drop by gravity and observing the length of the thread formed.</span></p>
<p dir="ltr"><b><span>• </span></b><b><span>Volume</span></b></p>
<p dir="ltr"><span>o </span><span>The volume of the ejaculate should be measured either with a graduated cylinder or by aspirating the whole sample into a wide - mouth pipette.</span></p>
<p dir="ltr"><b><span>• </span></b><b><span>pH</span></b></p>
<p dir="ltr"><span>o </span><span>The pH is determined by acidic secretions of the prostate and alkaline secretion of the seminal vesicles. It should normally be in the range of 7.2-8.0.</span></p>
<p dir="ltr"><span><b> </b></span><span><span><b>MICROSCOPIC INVESTIGATION</b></span></span><br />
<b><span>• </span></b><b><span>MOTILITY</span></b></p>
<p dir="ltr"><span>o </span><span>A drop of the semen is delivered onto a clean glass slide and covered with 22x22mm coverslip. The microscopic field is scanned systemically with X40 objective lens and a total of 100 spermatozoa are counted. The motility of the sperms is graded in percentage whether it shows</span><br />
<span> </span><br />
<span>a) active linear forward progressive motility</span><br />
<span>b) slow or sluggish progressive motility</span><br />
<span>c) non progressive motility</span><br />
<span>d) immotility</span><br />
<span> </span><br /><br /><br /><br /></p>
<p dir="ltr"><b><span>• </span></b><b><span>Agglutination</span></b></p>
<p dir="ltr"><span>o </span><span>Agglutination of sperms means that motile spermatozoa stick to each other, head to head, middle to middle, tail to tail, or mixed. In case of agglutination, semen culture must be performed in order to exclude infection with </span><i><span>Escherichia coli</span></i><span>.</span><br /></p>
<p dir="ltr"><b><span>• </span></b><b><span>Sperm Viability</span></b></p>
<p dir="ltr"><span>Vital staining of the spermatozoa allows quantification of the fraction of living cells independently of their motility. Live and dead spermatozoa are distinguished by adding one drop of 0.5% eosin y stain to one drop of semen at room temperature and smear the mixture on microscopic slide. Using the X40 objective, 100 spermatozoa are classified as either colored orange-red, if the stain has passed through the membrane and therefore the cell is dead, or non-stained, the cell being considered alive.</span><br /><br /></p>
<p dir="ltr"><b><span>• </span></b><b><span>Counting the spermatozoa</span></b></p>
<p dir="ltr"><span>In the haemocytometer method, a 1:20 dilution from each well mixed sample is prepared by diluting 50ul of liquefied semen with 950ul diluent. The latter is prepared by adding 50g of sodium carbonate, 10ml of 35%(v/v) formalin and make up the solution to a final volume of 1000ml.</span></p>
<p dir="ltr"><span>Using a Pasteur pipette, charge an improved Neubauer ruled chamber with well mixed solution. Wait 3-5minutes for the spermatozoa to settle. Using the X10 objective, count the number of the sperm cells in an area of 2 sq mm. (2 large squares). Calculate the number of spermatozoa in 1ml of fluid by the number counted by 100 000.</span></p>
<p dir="ltr"><b><span>• </span></b><b><span>ANALYSIS OF THE MORPHOLOGICAL CHARACTERISTICS OF SPERMATOZOA</span></b></p>
<p dir="ltr"><span>i. Make a thin smear of the liquefied well-mixed semen on a slide. While wet, fix the smear with 95% v/v ethanol for 5-10 minutes, and allow to air-dry.</span></p>
<p dir="ltr"><span>ii. Wash the smear with sodium bicarbonate-formalin solution to remove any mucus which may be present. Rinse the smear with several changes of water</span></p>
<p dir="ltr"><span>iii. Cover the smear with dilute (1 in 20) carbon fuchsin and allow to stain for 3 minutes. Wash off the stain with water</span></p>
<p dir="ltr"><span>iv. Counter stain, by covering the smear with dilute (1 in 20) Loeffler’s methylene blue for 2 minutes. Wash off the stain with water. Drain, and allow the smear to air-dry</span><br /><br /></p>
<p dir="ltr"><b><span>Staining results</span></b></p>
<p dir="ltr"><span>Nucleus of head………………………………………Dark blue</span><br />
<span>Cytoplasm of head……………………………………Pale blue</span><br />
<span>Middle piece and tail………………………………….Pink-red</span><br /></p>
<p dir="ltr"><b><span>NOMENCLATURE FOR SEMEN VARIABLES</span></b></p>
<p dir="ltr"><span><b>Normospermia</b></span><br />
<span>Normal sperm count, motility and morphology</span></p><p dir="ltr"><br />
<span><b>Oligozoospermia</b></span><br />
<span>Sperm count fewer than 20 million/ml.</span></p><p dir="ltr"><br />
<span><b>Asthenozoospermia</b></span><br />
<span>Fewer than 50% spermatozoa with forward progressive movement.</span></p><p dir="ltr"><br />
<span><b>Teratozoospermia</b></span><br />
<span>Fewer than 50% spermatozoa with normal morphology.</span></p><p dir="ltr"><br />
<span><b>Oligoasthenoteratozoospermia</b></span><br />
<span>Sperm count, forward progressive movement and morphology are disturbed (< 50%) .</span></p><p dir="ltr"><br />
<span><b>Azoospermia</b></span><br />
<span>No spermatozoa in an ejaculate</span><br />
<span>Aspermia</span><br />
<span>No ejaculate.</span><br />
</p><p dir="ltr"><span>COMPILED BY MEDICAL LAB. SCIENTIST, ANTHONY D. DZAMESI.</span></p><p dir="ltr"><span>To order for your semen analysis test and other fertility test for females contact Arkad medlab solutions: </span></p><p dir="ltr"><span>arkadmedlabsolutions@gmail.com</span></p><p dir="ltr"><span>Also contact us for quality herbal drug to cure male infertility.</span></p>Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-3973389828232632821.post-29747156545151530362020-09-05T07:59:00.002-07:002020-09-05T08:09:12.729-07:00Hepatitis B Profile : Meaning and interpretation<p> HEPATITIS B PROFILE INTERPRETATION</p><p></p><p dir="ltr"><span style="font-size: 32px;"><span style="font-size: 32px;">Hepatitis B profile</span></span></p>
<p dir="ltr"><span style="font-size: 22px;">HBsAg : positive means viral presence and can infect others.</span></p><p dir="ltr"><span style="font-size: 22px;"><br /></span>
<span style="font-size: 22px;"> HBsAb : positive means immunity due to clinical recovery or past infection.</span></p><p dir="ltr"><span style="font-size: 22px;"><br /></span>
<span style="font-size: 22px;"> HBeAg : positive means higher viral titre and means active virus in the liver or a stage of viral replication.</span></p><p dir="ltr"><span style="font-size: 22px;"><br /></span>
<span style="font-size: 22px;"> HBeAb : positive means no viral replication or a stage of HBeAg seroconversion.</span></p><p dir="ltr"><span style="font-size: 22px;"><br /></span>
<span style="font-size: 22px;"> HBcAb : positive means current infection or previous infection.</span></p><p dir="ltr"><span style="font-size: 22px;">If you test negative for hepatitis B, do well to vaccinate against the virus. </span></p><p dir="ltr"><span style="font-size: 22px;">For bulk purchase of hepatitis B vaccine, hepatitis B Profile testing kits, HBsAg test kits contact us : arkadmedlabsolutions@gmail.com</span></p><br /><p></p>Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-3973389828232632821.post-79894900978382141972020-07-10T14:55:00.001-07:002020-07-10T14:55:52.008-07:00SWARM PROTEUS<br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgV9npJYWMko8fRJpeInx3XH28QPPYFtikuVDBikqWggJQXVidhTYKorPRBfLrk6IajmIhUcW6pDTV-LjPH_yI8Gm1IkzTqSFFT8wzvxgOItNrx7QG9YTmfBH7iWJQXkHgO5fLeBR1udBk/s1417/20200710_215234.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="693" data-original-width="1417" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgV9npJYWMko8fRJpeInx3XH28QPPYFtikuVDBikqWggJQXVidhTYKorPRBfLrk6IajmIhUcW6pDTV-LjPH_yI8Gm1IkzTqSFFT8wzvxgOItNrx7QG9YTmfBH7iWJQXkHgO5fLeBR1udBk/s320/20200710_215234.jpg" width="320" /></a></div><div class="separator" style="clear: both; text-align: center;">Swarm! Proteus is a genus of enteric bacteria able to produce this swarming appearance through cellular coordination. Each phase of motility is marked by the distinct waves that are visible on the agar plate. The genus is a common cause of wound and urinary infections. #Arkadmedlab solutions</div>Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-3973389828232632821.post-42611855449239282652011-06-05T08:55:00.000-07:002011-06-05T08:55:15.389-07:00MICROBIOLOGY- BLOOD CULTURE<div dir="ltr" style="text-align: left;" trbidi="on"><!--[if !mso]> <style>
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<div align="center" class="MsoNormal" style="text-align: center;"><b><u><span style="font-size: 20pt;">BLOOD CULTURE</span></u></b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b><u>PRINCIPLE:</u></b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><span> </span>The isolation and identification of all organisms which may cause infection</div><div class="MsoNormal"><span> </span>The determination of their sensitivities.</div><div class="MsoNormal"><br />
</div><table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-collapse: collapse; border: medium none;"><tbody>
<tr> <td style="border: 1pt solid windowtext; padding: 0in 5.4pt; width: 76.2pt;" valign="top" width="102"> <div class="MsoNormal"><b>Personnel</b></div></td> <td style="border-color: windowtext windowtext windowtext -moz-use-text-color; border-style: solid solid solid none; border-width: 1pt 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal"><b>Student Technician</b></div></td> <td style="border-color: windowtext windowtext windowtext -moz-use-text-color; border-style: solid solid solid none; border-width: 1pt 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal"><b>Laboratory Assistant</b></div></td> <td style="border-color: windowtext windowtext windowtext -moz-use-text-color; border-style: solid solid solid none; border-width: 1pt 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal"><b>Rotating Technician</b></div></td> <td style="border-color: windowtext windowtext windowtext -moz-use-text-color; border-style: solid solid solid none; border-width: 1pt 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal"><b>Technician</b></div></td> <td style="border-color: windowtext windowtext windowtext -moz-use-text-color; border-style: solid solid solid none; border-width: 1pt 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><b>Technologist</b></div></td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 76.2pt;" valign="top" width="102"> <div class="MsoNormal">Specimen sorting and numbering</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal"> </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal"> </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal"> </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal"> </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"> </div></td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 76.2pt;" valign="top" width="102"> <div class="MsoNormal">Subculture</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal"> </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal"> </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal"> </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal"> </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"> </div></td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 76.2pt;" valign="top" width="102"> <div class="MsoNormal">Interpretation of Culture</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal">* </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal">* </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal"> </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal"> </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"> </div></td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 76.2pt;" valign="top" width="102"> <div class="MsoNormal">Identification</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal">* </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal">* </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal"> </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal"> </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"> </div></td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 76.2pt;" valign="top" width="102"> <div class="MsoNormal">Sensitivity</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal">* </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal">* </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal"> </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal"> </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"> </div></td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 76.2pt;" valign="top" width="102"> <div class="MsoNormal">Reporting</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal"><br />
</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal"><br />
</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal">* </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.2pt;" valign="top" width="98"> <div class="MsoNormal">* </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"> </div></td> </tr>
</tbody></table><div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>*Under supervision only</b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal">Safety<span> </span>Wear gloves</div><div class="MsoNormal"><span> </span>-<span> </span>Aseptic technique/Class II safety cabinet</div><div class="MsoNormal"><br />
</div><div class="MsoNormal">Reception<span> </span>-<span> </span>Incubate blood bottles immediately at 37<span style="font-family: "Antique Olive","sans-serif";">º</span>C</div><div class="MsoNormal"><br />
</div><div class="MsoNormal">Equipment/reagents-<span> </span>Glass slides, Media, anaerobic jar, Gaspak and Gram stain.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b><u>DAY OF RECEIPT</u></b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><span> </span>a.<span> </span>Note date and number of specimen</div><div class="MsoNormal"><span> </span>b.<span> </span>Incubate immediately at 35<span style="font-family: "Antique Olive","sans-serif";">º</span>C.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>DAY ONE</b> (after 24hrs incubation)</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><span> </span>Inspect all bottles for evidence of growth</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>NOTE</b>:<span> </span>-<span> </span>Uniform or subsurface turbidity</div><div class="MsoNormal" style="margin-left: 1.75in; text-indent: -0.25in;"><span>-<span style="font: 7pt "Times New Roman";"> </span></span>evidence of haemolysis</div><div class="MsoNormal" style="margin-left: 1.75in; text-indent: -0.25in;"><span>-<span style="font: 7pt "Times New Roman";"> </span></span>presence of colonies in the blood layer</div><div class="MsoNormal" style="margin-left: 1.75in; text-indent: -0.25in;"><span>-<span style="font: 7pt "Times New Roman";"> </span></span>gas production</div><div class="MsoNormal" style="margin-left: 1.75in; text-indent: -0.25in;"><span>-<span style="font: 7pt "Times New Roman";"> </span></span>coagulation of the bottle</div><div class="MsoNormal" style="margin-left: 1.75in; text-indent: -0.25in;"><span>-<span style="font: 7pt "Times New Roman";"> </span></span>a surface pellicle</div><div class="MsoNormal" style="margin-left: 1.75in; text-indent: -0.25in;"><span>-<span style="font: 7pt "Times New Roman";"> </span></span>etc.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>a.<span> </span>Gram staining</b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><span> </span>The bottle is opened aseptically, a small amount of broth is removed with a sterile loop or Pasteur pipette, and a Gram stained smear is examined for the presence of microorganisms and subcultured on <span> </span>an appropriate media.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal">b.<span> </span>Subculture</div><div class="MsoNormal"><span> </span></div><div class="MsoNormal"><span> </span>All bottles onto BA<sub>o2</sub>, BA<sub>ano2</sub>, MacConkey for 18-24hrs</div><div class="MsoNormal"><span> </span>Add CA + 5% Co2 for 48hrs if N. meningitidis is suspected or Gram stain show <span> </span>Gram negative diplococci.</div><div class="MsoNormal"><span> </span>Add Sabourand in suspected candida infection.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal">c.<span> </span>Direct-sensitivity</div><div class="MsoNormal"><span> </span></div><div class="MsoNormal"><span> </span>Using blood culture medium (positive growth) as inocular if necessary.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal">d.<span> </span>Re-incubate all bottles</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b><u>DAY TWO</u></b>:<span> </span>a.<span> </span>Signed preliminary reports to wards (CLSCP)</div><div class="MsoNormal"><span> </span></div><div class="MsoNormal" style="margin-left: 135pt; text-indent: -0.5in;"><span>(i)<span style="font: 7pt "Times New Roman";"> </span></span>NBG after 48hrs incubation for all Negatives</div><div class="MsoNormal" style="margin-left: 135pt; text-indent: -0.5in;"><span>(ii)<span style="font: 7pt "Times New Roman";"> </span></span>Gram report for positives stating further report to follow</div><div class="MsoNormal"><br />
</div><div class="MsoNormal" style="margin-left: 1in;">b.<span> </span>Indicate on the request card that the Preliminary Report has been <span> </span>sent.</div><div class="MsoNormal" style="margin-left: 1in;"><br />
</div><div class="MsoNormal" style="margin-left: 0.75in;"><span> </span>c.<span> </span> Do further identification tests on Positives plus sensitivity test.<span> </span><span> </span><span> </span>The choice of antibiotic disks will depend on the result of the <span> </span><span> </span>Gram stain.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b><u>DAY THREE </u></b><span> </span>a.<span> </span>Read biochemical results an write reports</div><div class="MsoNormal" style="margin-left: 1in; text-indent: 12pt;">b. <span> </span>Record all signed reports in the book and send report to the ward </div><div class="MsoNormal" style="margin-left: 1.5in;">(CLSCP) Central Laboratory &Specimen Collection Point.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b><u>NOTE</u>:<span> </span></b><span> </span>1.<span> </span>Examine all bottles daily for evidence of growth, and do<span> </span><span> </span><span> </span>subculture after 7 days incubation.</div><div class="MsoNormal"><span> </span></div><div class="MsoNormal"><span> </span>2. <span> </span>Discard positive plates after results have been signed</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b><u>BACTERIAL ENDOCARDITIS/VALVE ABNORMALITY</u></b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal">These culture bottles are incubated for a total of 3 weeks, where (3) cultures have been received.<span> </span>Bottles should be subcultured on days 2, 7, 14, and 21.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal">BRUCELLOSIS</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><span> </span>Bottles should be incubated for a total of six(6) weeks.</div><div class="MsoNormal"><span> </span>All manipulation must be performed in the microbiological safety cabinet.</div><div class="MsoNormal"><span> </span>Biochemical Tests – Indole, Urea, Citrate, TSI, Motility Test.</div><div class="MsoNormal"><br />
</div><table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-collapse: collapse; border: medium none;"><tbody>
<tr> <td style="border: 1pt solid windowtext; padding: 0in 5.4pt; width: 101.15pt;" valign="top" width="135"> <div class="MsoNormal"><b>GRAM RESULT</b></div></td> <td style="border-color: windowtext windowtext windowtext -moz-use-text-color; border-style: solid solid solid none; border-width: 1pt 1pt 1pt medium; padding: 0in 5.4pt; width: 2.05in;" valign="top" width="197"> <div class="MsoNormal"><b>PLATES AND TESTS</b></div></td> <td style="border-color: windowtext windowtext windowtext -moz-use-text-color; border-style: solid solid solid none; border-width: 1pt 1pt 1pt medium; padding: 0in 5.4pt; width: 2.05in;" valign="top" width="197"> <div class="MsoNormal"><b>DIRECT SENSITIVITY</b></div></td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 101.15pt;" valign="top" width="135"> <div class="MsoNormal">GPC?</div><div class="MsoNormal">Staphylococcus</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 2.05in;" valign="top" width="197"> <div class="MsoNormal">BA<sub>1</sub><sup>-</sup><sub>02</sub>, CAC<sub>O2</sub> Ano<sub>2</sub></div><div class="MsoNormal">Sensitivity + Methicillin at 30<span style="font-family: "Antique Olive","sans-serif";">º</span>C</div><div class="MsoNormal">Direct tube coagulase</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 2.05in;" valign="top" width="197"> <div class="MsoNormal">*Penicillin, Tetracycline,</div><div class="MsoNormal">Erythromycin, Gentamicin,</div><div class="MsoNormal">Cefuroxime, Methicillin</div></td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 101.15pt;" valign="top" width="135"> <div class="MsoNormal">GPC? Streptococcus</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 2.05in;" valign="top" width="197"> <div class="MsoNormal">BA<sub>1-</sub>O2, CA Co<sub>2</sub> Ano<sub>2</sub></div><div class="MsoNormal">Test, Sensitivity on BAO2</div><div class="MsoNormal">Direct Strept. Grouping</div><div class="MsoNormal">**Latex for Strept. Pneumonia</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 2.05in;" valign="top" width="197"> <div class="MsoNormal">*Penicillin, Ampicillin</div><div class="MsoNormal">Erythromycin, Tetracycline</div></td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 101.15pt;" valign="top" width="135"> <div class="MsoNormal">GNR – Large</div><div class="MsoNormal">?Coliform</div><div class="MsoNormal">?Pseudomonas</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 2.05in;" valign="top" width="197"> <div class="MsoNormal"><span> </span>BA<sub>1-</sub>O2, CA Co<sub>2</sub> Ano<sub>2</sub></div><div class="MsoNormal">MacConkey</div><div class="MsoNormal">NLF check oxidase</div><div class="MsoNormal">If negative oxidase, other Gneg.tests</div><div class="MsoNormal">Check Pso/PSH/Vi</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 2.05in;" valign="top" width="197"> <div class="MsoNormal">*Ampicillin, Cefuroxime,</div><div class="MsoNormal">Ciprofloxacin</div><div class="MsoNormal">Gentamicin</div><div class="MsoNormal">Ceftazidime</div><div class="MsoNormal">Gentamicin Chloramphenicol </div></td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 101.15pt;" valign="top" width="135"> <div class="MsoNormal">GNR – small?</div><div class="MsoNormal">HI</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 2.05in;" valign="top" width="197"> <div class="MsoNormal">CA CO<sub>2</sub>, BA Ano<sub>2</sub></div><div class="MsoNormal">Direct HI latex agglutination</div><div class="MsoNormal">Requirement for X & V</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 2.05in;" valign="top" width="197"> <div class="MsoNormal"><br />
</div></td> </tr>
</tbody></table><ul style="margin-top: 0in;" type="disc"><li class="MsoNormal">For patients on antibiotic treatment, set up sensitivity tests for those drugs</li>
</ul><div class="MsoNormal" style="margin-left: 0.5in;">when available</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div><div class="MsoNormal" style="line-height: 150%;">DIRECT LATEX FOR HI(Hinfluenae) 1 drop supernatant + 1 drop of latex</div><div class="MsoNormal" style="line-height: 150%;">DIRECT TUBE COAGULASE<span> </span>-<span> </span>1 drop of blood/broth into diluted plasma</div><div class="MsoNormal" style="line-height: 150%;">DIRECT STREPT. GROUPING<span> </span>-<span> </span>1 drop of blood/broth against each group.</div><div class="MsoNormal" style="line-height: 150%;">BIOCHEMICAL TEST<span> </span>Indole, Urea, Citrate, TSI + motility Test</div><div class="MsoNormal" style="line-height: 150%;"><br />
</div><div class="MsoNormal" style="line-height: 150%;"><br />
</div><div class="MsoNormal" style="line-height: 150%;"><b><u>TO SUBCULTURE BOTTLES</u></b></div><div class="MsoNormal" style="line-height: 150%;"><br />
</div><div class="MsoNormal" style="line-height: 150%; margin-left: 1in; text-indent: -0.25in;"><span>1.<span style="font: 7pt "Times New Roman";"> </span></span>Gently shake bottles to resuspend the erythrocytes</div><div class="MsoNormal" style="margin-left: 1in; text-indent: -0.25in;"><span>2.<span style="font: 7pt "Times New Roman";"> </span></span>Using a loop, subculture onto BA<sub>02</sub>, BA<sub>Ano2</sub>CA + 5% and MacConkey.<span> </span>Incubate for 24-48hrs.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>Final subculture</b></div><div class="MsoNormal" style="line-height: 150%;"><br />
</div><div class="MsoNormal" style="line-height: 150%;">Do final subculture and discard bottles after 7 days incubation except for suspected brucellosis and endocarditis(see below)</div><div class="MsoNormal" style="line-height: 150%;"><br />
</div><div class="MsoNormal" style="line-height: 150%;"><b>Note</b>:<span> </span>i.<span> </span>Technologist to see Biochemical reaction & Sensitivity plate before <span> </span>signing of report</div><div class="MsoNormal" style="line-height: 150%;"><br />
</div><div class="MsoNormal" style="line-height: 150%;"><span> </span>Ii<span> </span>Isolates are to be kept on slopes.(for storage)</div><div class="MsoNormal" style="line-height: 150%;"><br />
</div><div class="MsoNormal" style="line-height: 150%;"><br />
</div><div class="MsoNormal" style="line-height: 150%;"><b>Reporting:</b></div><div class="MsoNormal" style="line-height: 150%;"><br />
</div><table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-collapse: collapse; border: medium none;"><tbody>
<tr> <td style="border: 1pt solid windowtext; padding: 0in 5.4pt; width: 6.15in;" valign="top" width="590"> <ol start="1" style="margin-top: 0in;" type="1"><li class="MsoNormal" style="line-height: 150%;">Preliminary report</li>
<li class="MsoNormal" style="line-height: 150%;">Final report</li>
</ol><div class="MsoNormal" style="line-height: 150%; margin-left: 83.25pt; text-indent: -29.25pt;"><span>a.<span style="font: 7pt "Times New Roman";"> </span></span>Significant growth with Sensitivities</div><div class="MsoNormal" style="line-height: 150%; margin-left: 83.25pt; text-indent: -29.25pt;"><span>b.<span style="font: 7pt "Times New Roman";"> </span></span>Mixed growth (Indicate types of organisms in day book)</div><div class="MsoNormal" style="line-height: 150%; margin-left: 0.75in;"><span> </span></div><div class="MsoNormal" style="line-height: 150%; margin-left: 0.75in;"><span> </span>Request repeat specimen <b>DISCUSS WITH TECHNOLOGIST</b></div><div class="MsoNormal" style="line-height: 150%; margin-left: 0.25in;">BY BMS DZAMESI </div></td> </tr>
</tbody></table></div>Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-3973389828232632821.post-37380751246571383432011-06-05T08:40:00.000-07:002011-06-05T08:40:38.177-07:00MICROBIOLOGY- STOOL CULTURE AND SENSITIVITY<div dir="ltr" style="text-align: left;" trbidi="on"><!--[if !mso]> <style>
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<div class="MsoNormal"><b>STOOL CULTURE</b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>PRINCIPLE:</b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal">The isolation and identification enteric pathogens (Salmonella/Shigella and determination of their </div><div class="MsoNormal" style="margin-left: 4in;"><br />
</div><table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-collapse: collapse; border: medium none; width: 631px;"><tbody>
<tr> <td style="border: 1pt solid windowtext; padding: 0in 5.4pt; width: 131.4pt;" valign="top" width="175"> <div class="MsoNormal"><span> </span>Personnel</div><div class="MsoNormal"><br />
</div></td> <td style="border-color: windowtext windowtext windowtext -moz-use-text-color; border-style: solid solid solid none; border-width: 1pt 1pt 1pt medium; padding: 0in 5.4pt; width: 70.85pt;" valign="top" width="94"> <div class="MsoNormal">Student Technician</div></td> <td style="border-color: windowtext windowtext windowtext -moz-use-text-color; border-style: solid solid solid none; border-width: 1pt 1pt 1pt medium; padding: 0in 5.4pt; width: 64.15pt;" valign="top" width="86"> <div class="MsoNormal">Laboratory Assistant</div></td> <td style="border-color: windowtext windowtext windowtext -moz-use-text-color; border-style: solid solid solid none; border-width: 1pt 1pt 1pt medium; padding: 0in 5.4pt; width: 69.35pt;" valign="top" width="92"> <div class="MsoNormal">Rotating </div><div class="MsoNormal">Technician </div></td> <td style="border-color: windowtext windowtext windowtext -moz-use-text-color; border-style: solid solid solid none; border-width: 1pt 1pt 1pt medium; padding: 0in 5.4pt; width: 64.15pt;" valign="top" width="86"> <div class="MsoNormal">Technician </div></td> <td style="border-color: windowtext windowtext windowtext -moz-use-text-color; border-style: solid solid solid none; border-width: 1pt 1pt 1pt medium; padding: 0in 5.4pt; width: 73.5pt;" valign="top" width="98"> <div class="MsoNormal">Technologist </div></td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 131.4pt;" valign="top" width="175"> <div class="MsoNormal">Specimen Sorting and numbering </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 70.85pt;" valign="top" width="94"> </td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 64.15pt;" valign="top" width="86"> </td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 69.35pt;" valign="top" width="92"> </td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 64.15pt;" valign="top" width="86"> </td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.5pt;" valign="top" width="98"> </td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 131.4pt;" valign="top" width="175"> <div class="MsoNormal">Culture</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 70.85pt;" valign="top" width="94"> <div class="MsoNormal"><br />
</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 64.15pt;" valign="top" width="86"> </td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 69.35pt;" valign="top" width="92"> </td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 64.15pt;" valign="top" width="86"> </td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.5pt;" valign="top" width="98"> </td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 131.4pt;" valign="top" width="175"> <div class="MsoNormal">Interpretation of Culture </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 70.85pt;" valign="top" width="94"> <div class="MsoNormal"><br />
</div><div class="MsoNormal"><span> </span>*</div><div class="MsoNormal"><br />
</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 64.15pt;" valign="top" width="86"> <div class="MsoNormal"><span> </span></div><div class="MsoNormal"><span> </span>*</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 69.35pt;" valign="top" width="92"> <div class="MsoNormal"><br />
</div><div class="MsoNormal"><span> </span>*</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 64.15pt;" valign="top" width="86"> </td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.5pt;" valign="top" width="98"> </td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 131.4pt;" valign="top" width="175"> <div class="MsoNormal">Identification Tests</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 70.85pt;" valign="top" width="94"> <div class="MsoNormal"><span> </span></div><div class="MsoNormal"><span> </span>*</div><div class="MsoNormal"><br />
</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 64.15pt;" valign="top" width="86"> </td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 69.35pt;" valign="top" width="92"> </td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 64.15pt;" valign="top" width="86"> </td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.5pt;" valign="top" width="98"> </td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 131.4pt;" valign="top" width="175"> <div class="MsoNormal">Sensitivity Tests</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 70.85pt;" valign="top" width="94"> <div class="MsoNormal"><br />
</div><div class="MsoNormal"><span> </span>*</div><div class="MsoNormal"><span> </span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 64.15pt;" valign="top" width="86"> </td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 69.35pt;" valign="top" width="92"> </td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 64.15pt;" valign="top" width="86"> </td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.5pt;" valign="top" width="98"> </td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 131.4pt;" valign="top" width="175"> <div class="MsoNormal">Reporting </div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 70.85pt;" valign="top" width="94"> <div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 64.15pt;" valign="top" width="86"> <div class="MsoNormal"><br />
</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 69.35pt;" valign="top" width="92"> <div class="MsoNormal"><br />
</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 64.15pt;" valign="top" width="86"> </td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.5pt;" valign="top" width="98"> </td> </tr>
</tbody></table><div class="MsoNormal"><br />
</div><div class="MsoNormal">*Under supervision only</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>Safety<span> </span></b><span> </span>wear gloves</div><div class="MsoNormal"><span> </span>Open bench</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>Reception</b> – stool specimens are receive in the laboratory on a suitable wide-mouth non-sterile container (mono wax) or in the form of a rectal swab. Specimen should promptly be delivered to the laboratory for processing.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>Equipment/media </b></div><div class="MsoNormal">Inoculating loops, Dexoxycholate citrate Agar (DCA) or Salmonella Shigella Agar (SS),MacConkey with crystal violet, Selenite F broth, Triple Sugar Iron (TSI)Agar. Urea Agar slope peptone water.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal">Macroscopic examination:</div><div class="MsoNormal">Note the presence of mucus and blood </div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>CULTURE</b></div><div class="MsoNormal">Note:<span> </span>(i)<span> </span><span> </span>technologist to see Biochemical reaction & sensitivity plate before signing </div><div class="MsoNormal"><span> </span>of report.</div><div class="MsoNormal"><span> </span><span> </span>(ii)<span> </span>isolates are to be kept on slopes. (for storage)</div><div class="MsoNormal"><b>DAY 1</b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal">1.<span> </span><span> </span>Inoculate a loopful of the stool specimen (if loose or watery) or a peanut size if </div><div class="MsoNormal"><span> </span><span> </span>formed) on to DCA/SS Agar and MacConkey Agar (with 1 crystal violet). Also </div><div class="MsoNormal"><span> </span>inoculate Selenite F broth with about 2 – 3 times the size of sample used for solid </div><div class="MsoNormal"><span> </span>media. Incubate the seeded media overnight aerobically at 35 -37oC</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>DAY 2</b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>EXAMINATION AND IDENTIFICATION</b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal">Routine identification of suspected Salmonella and shigella isolates:</div><div class="MsoNormal"><br />
</div><div class="MsoNormal" style="margin-left: 1.25in; text-indent: -0.25in;"><span>1.<span style="font: 7pt "Times New Roman";"> </span></span>UREASE TEST using a sterile straight wire pick an individual clourless smooth colony with or without black spot in the centre on the DCA/SS and inoculate a tube of Peptone water and Urea Agar slope.</div><div class="MsoNormal" style="margin-left: 1.25in; text-indent: -0.25in;"><span>2.<span style="font: 7pt "Times New Roman";"> </span></span>Incubate at 35-37oC up to 4 hours examining at hourly intervals for a pink colour throughout the urea agar slope.</div><div class="MsoNormal" style="margin-left: 1.25in; text-indent: -0.25in;"><span>3.<span style="font: 7pt "Times New Roman";"> </span></span>If urease test is negative at 4 hours incolate a tube of TSI/KIA with a sterile straight wire from the peptone water tube or similar smooth colony stabbing first the butt and then streaking the slope. Close the tube with a loose-fitting cap and incubate at 35-37oC overnight.</div><div class="MsoNormal" style="margin-left: 1.25in; text-indent: -0.25in;"><span>4.<span style="font: 7pt "Times New Roman";"> </span></span>PURITY PLATE</div><div class="MsoNormal" style="margin-left: 1.25in;">inculate Macconkey plate with same colony as purity plate for serology.</div><div class="MsoNormal" style="margin-left: 1.25in; text-indent: -0.25in;"><span>5.<span style="font: 7pt "Times New Roman";"> </span></span>ENRICHMENT BROTH</div><div class="MsoNormal" style="margin-left: 1.25in;">Sub-culture the Selenite F broth culture on a plate of DCA/SS Agar and follow up as above on Day 3. this is necessary if no colonies resembling Salmonella spp are seen on the primary culture plates. Discard selenite F. broth.</div><div class="MsoNormal"><span> </span></div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>DAY 3</b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal" style="margin-left: 1in;">1.<span> </span><span> </span><span> </span>Examine the TSI/KIA Urea Agar slope, iodole etc for reactions <span> </span></div><div class="MsoNormal" style="margin-left: 1in;"><span> </span><span> </span>suggestive of Salmonella or Shigella.</div><div class="MsoNormal" style="margin-left: 1in;">2.<span> </span>Test serologically and isolate giving reactions suggestive ofSalmonella<span> </span></div><div class="MsoNormal" style="margin-left: 1in;"><span> </span><span> </span>technique. Subculture on MacConkey for purity to make sure you are<span> </span></div><div class="MsoNormal" style="margin-left: 1in;"><span> </span>dealing with non-lactose fermented.</div><div class="MsoNormal" style="margin-left: 1in;">3.<span> </span>Perform sensitivity test on the isolate using appropriate antibiotic </div><div class="MsoNormal" style="margin-left: 1in;"><span> </span>discs. Include a control E. coli strain on a separate sensitivity test agar</div><div class="MsoNormal"><span> </span>plate.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>ADDITIONAL TESTS</b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal">For stool specimens pf infants up to 2 years inoculate one of the Lactose fermenting rose-pink colonies on MacCoonkey plate into Peptone water, kosers citrate, Urea Agar slope and TSI for the isolation of E. coli. If E. coli is isolated test serologically for the appropriate E. coli stains (ETEC,EIEC, EPEC or EHEC) </div><div class="MsoNormal"><br />
</div><div class="MsoNormal">Summary of the laboratory examination of Raecal Specimens</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>DAY 1</b><span> </span><u>Culture</u></div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><u>Primary Plating Media<span> </span></u><span> </span>SS Agar or DCA<u><span> </span></u></div><div class="MsoNormal"><span> </span>MacConkey with Crystal violet (children less than 2 years)</div><div class="MsoNormal"><br />
</div><div class="MsoNormal">Enrichment:<span> </span>Selenite F</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>DAY 2</b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal">1<span> </span>Examine SS/DCA culture for NLF’s</div><div class="MsoNormal"><span> </span>Salomnella species</div><div class="MsoNormal"><span> </span><span> </span>Shigella species </div><div class="MsoNormal"><br />
</div><div class="MsoNormal">2.<span> </span>Inoculate Peptone water & Urea</div><div class="MsoNormal"><span> </span>If no Urease production after 4 hrs</div><div class="MsoNormal"><span> </span>Inoculate<span> </span>1.<span> </span>TSI/KIA incubate at 35oC – 37oC.</div><div class="MsoNormal" style="margin-left: 45pt;"><span> </span><span> </span>2.<span> </span>MacConkey Agar for Purity and serology.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div><div class="MsoNormal">3.<span> </span>Also subculture the selenite F culture on SS/DCA. This is important if there is not </div><div class="MsoNormal"><span> </span>growth suggestive of Salmonella or shigella on the Primary Culture.</div><div class="MsoNormal"><span> </span></div><div class="MsoNormal"><b>Cholera</b></div><div class="MsoNormal">If suspected, cholera specimens should be sent to the Public Health Reference Laboratory </div><div class="MsoNormal"><br />
</div><div class="MsoNormal">Reporting </div><div class="MsoNormal">1. Report the type of Salmonella or Shigella spp isolated with the sensitivity on Day 4</div><div class="MsoNormal"><br />
</div><div class="MsoNormal">2. If there was no suggestive isolate report as:</div><div class="MsoNormal"><span> </span>No Salmonella or Shigella isolated.</div><div class="MsoNormal">BY BMS DZAMESI </div></div>Unknownnoreply@blogger.com1tag:blogger.com,1999:blog-3973389828232632821.post-28189458731119170422011-06-05T08:28:00.000-07:002011-06-05T08:28:23.007-07:00MICROBIOLOGY- URINE CULTURE AND SENSITIVITY<div dir="ltr" style="text-align: left;" trbidi="on"><!--[if gte mso 9]><xml> <o:OfficeDocumentSettings> <o:RelyOnVML/> <o:AllowPNG/> </o:OfficeDocumentSettings> </xml><![endif]--><!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves/> <w:TrackFormatting/> <w:PunctuationKerning/> <w:ValidateAgainstSchemas/> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF/> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables/> <w:SnapToGridInCell/> <w:WrapTextWithPunct/> <w:UseAsianBreakRules/> <w:DontGrowAutofit/> <w:SplitPgBreakAndParaMark/> <w:DontVertAlignCellWithSp/> <w:DontBreakConstrainedForcedTables/> <w:DontVertAlignInTxbx/> <w:Word11KerningPairs/> <w:CachedColBalance/> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math"/> <m:brkBin m:val="before"/> <m:brkBinSub m:val="--> <m:smallfrac m:val="off"> <m:dispdef> <m:lmargin m:val="0"> <m:rmargin m:val="0"> <m:defjc m:val="centerGroup"> <m:wrapindent m:val="1440"> <m:intlim m:val="subSup"> <m:narylim m:val="undOvr"> </m:narylim></m:intlim> </m:wrapindent><!--[endif]--><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true"
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<div align="center" class="MsoNormal" style="text-align: center;"><b><span style="font-size: 20pt;">URINE CULTURE AND SENSITIVITY</span></b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>PRINCIPLE:</b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal">The isolation and identification of Significant bacteriuria in urine.<span> </span>Sensitivity testing should be performed on the organism(s)</div><div class="MsoNormal"><br />
</div><table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-collapse: collapse; border: medium none;"><tbody>
<tr> <td style="border: 1pt solid windowtext; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal">Personnel</div></td> <td style="border-color: windowtext windowtext windowtext -moz-use-text-color; border-style: solid solid solid none; border-width: 1pt 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal">Student Technician</div></td> <td style="border-color: windowtext windowtext windowtext -moz-use-text-color; border-style: solid solid solid none; border-width: 1pt 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal">Assistant Technician</div></td> <td style="border-color: windowtext windowtext windowtext -moz-use-text-color; border-style: solid solid solid none; border-width: 1pt 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal">Rotation Technician</div></td> <td style="border-color: windowtext windowtext windowtext -moz-use-text-color; border-style: solid solid solid none; border-width: 1pt 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal">Technician</div></td> <td style="border-color: windowtext windowtext windowtext -moz-use-text-color; border-style: solid solid solid none; border-width: 1pt 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal">Technologist</div></td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal">Specimen Sorting and numbering</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><span style="font-family: "Arial","sans-serif";">□</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal">*<span style="font-family: "Arial","sans-serif";">□</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><span style="font-family: "Arial","sans-serif";">□</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><span style="font-family: "Arial","sans-serif";">□</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><span style="font-family: "Arial","sans-serif";">□</span></div></td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal">Microscopy</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><span style="font-family: "Arial","sans-serif";">□</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal">*<span style="font-family: "Arial","sans-serif";">□</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><span style="font-family: "Arial","sans-serif";">□</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><span style="font-family: "Arial","sans-serif";">□</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><span style="font-family: "Arial","sans-serif";">□</span></div></td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal">Culture</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><span style="font-family: "Arial","sans-serif";">*□</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal">*<span style="font-family: "Arial","sans-serif";">□</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><span style="font-family: "Arial","sans-serif";">□</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><span style="font-family: "Arial","sans-serif";">□</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><span style="font-family: "Arial","sans-serif";">□</span></div></td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal">Interpretation of cultures</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><br />
</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><br />
</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><span style="font-family: "Arial","sans-serif";">□</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><span style="font-family: "Arial","sans-serif";">□</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><span style="font-family: "Arial","sans-serif";">□</span></div></td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal">Sensitivity test</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><br />
</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><br />
</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><span style="font-family: "Arial","sans-serif";">□</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><span style="font-family: "Arial","sans-serif";">□</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><span style="font-family: "Arial","sans-serif";">□</span></div></td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal">Reporting</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><br />
</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><br />
</div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><span style="font-family: "Arial","sans-serif";">*□</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><span style="font-family: "Arial","sans-serif";">□</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 73.8pt;" valign="top" width="98"> <div class="MsoNormal"><span style="font-family: "Arial","sans-serif";">□</span></div></td> </tr>
</tbody></table><div class="MsoNormal">*Under supervision only.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>Safety</b>:<span> </span>Wear gloves</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>Reception</b>:<span> </span>Inoculate immediately or refrigerated at 4<span style="font-family: "Antique Olive","sans-serif";">º</span>C for not more than 18 hours after collection.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>Equipment/Reagent:</b></div><div class="MsoNormal">Calibrated Standard loop (1/500) or 1/400).</div><div class="MsoNormal">Microscope Slides, Cover glass, Pasteur pipette, Beakers, Racks, Saline, CLED(or BA and Mac) DSTA, (CA) when needed, Peptone water Urea, Citrate, TSI, Antibiotic discs, Plasma, Gram/Z-N Stains when needed, test tubes, Sterile centrifuge tubes and Centrifuge.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>DAY 1</b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal">Test Procedure:</div><div class="MsoNormal">(Semi-quantitative Standard loop Method)</div><div class="MsoNormal"><br />
</div><div class="MsoNormal">Mid-Stream Urine (MSU)<span> </span>is the usual specimen (see others below)</div><div class="MsoNormal" style="margin-left: 38.25pt; text-indent: -20.25pt;"><span>(1)<span style="font: 7pt "Times New Roman";"> </span></span>mix the urine sample carefully by rotation but not by inversion (to avoid any contamination if the lid is loose).</div><div class="MsoNormal" style="margin-left: 38.25pt; text-indent: -20.25pt;"><span>(2)<span style="font: 7pt "Times New Roman";"> </span></span>Dip the standard loop (1/400 or 1/500ml) vertically into the urine and inoculate onto ¼ Cystine Lactose, Electrolyte Deficient (CLED) Agar or Blood Agar (BA) and MacConkey Agar (Mac) plates.<span> </span>Only the ring of the loop should enter the urine.</div><div class="MsoNormal" style="margin-left: 38.25pt; text-indent: -20.25pt;"><span>(3)<span style="font: 7pt "Times New Roman";"> </span></span>Incubate aerobically at 35-75<span style="font-family: "Antique Olive","sans-serif";">º</span>C overnight (For N gonorrhoeae put deposit on Chocolate agar, (send deposit for TB culture to PHL)</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><span> </span>Fig 1</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>Microscopy:</b></div><div class="MsoNormal">Put 2 drops of well mixed uncentrifuged urine onto a Slide.<span> </span>Apply a cover slip.<span> </span>Examine with a x 10, objective for WBC/RBC/Epithelial Cells and bacteria.<span> </span>To identify type of cells or casts use x 40 objective.<span> </span>Count number of cells in 10 fields and express the results as per High power field.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal">In emergency cases</div><ul style="margin-top: 0in;" type="disc"><li class="MsoNormal">Put up direct Sensitivity test on urine containing.</li>
</ul><div class="MsoNormal" style="margin-left: 37.5pt; text-indent: -19.5pt;"><span>(1)<span style="font: 7pt "Times New Roman";"> </span></span>20 or more WBC per field</div><div class="MsoNormal" style="margin-left: 37.5pt; text-indent: -19.5pt;"><span>(2)<span style="font: 7pt "Times New Roman";"> </span></span>Bacteria</div><div class="MsoNormal" style="margin-left: 37.5pt; text-indent: -19.5pt;"><span>(3)<span style="font: 7pt "Times New Roman";"> </span></span>Both bacteria and 20 or more WBC</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>DAY 2</b></div><div class="MsoNormal" style="margin-left: 37.5pt; text-indent: -19.5pt;"><span>(1)<span style="font: 7pt "Times New Roman";"> </span></span>Examine plate.<span> </span><b>Note the degree of growth</b> on each ¼ plate (Fig 1)</div><div class="MsoNormal" style="margin-left: 37.5pt; text-indent: -19.5pt;"><span>(2)<span style="font: 7pt "Times New Roman";"> </span></span>Interpretation of culture</div><div class="MsoNormal" style="margin-left: 1.25in; text-indent: -0.5in;"><span>i.<span style="font: 7pt "Times New Roman";"> </span></span>No bacterial growth</div><div class="MsoNormal" style="margin-left: 1.25in; text-indent: -0.5in;"><span>ii.<span style="font: 7pt "Times New Roman";"> </span></span>No significant growth less than (<) 200 cfu</div><div class="MsoNormal" style="margin-left: 1.25in; text-indent: -0.5in;"><span>iii.<span style="font: 7pt "Times New Roman";"> </span></span>Significant growth:-</div><div class="MsoNormal" style="margin-left: 0.75in;"><span> </span>With a 1/400 ml loop approximately 250 cfu</div><div class="MsoNormal" style="margin-left: 0.75in;"><span> </span>With a 1/500 ml loop approximately 200 cfu</div><div class="MsoNormal" style="margin-left: 0.75in;">This is proportional to > 10<sup>8</sup> bacteria./Litre (.> 10<sup>5</sup> bacteria/ml)</div><div class="MsoNormal"><br />
</div><div class="MsoNormal" style="margin-left: 37.5pt; text-indent: -19.5pt;"><b><span>(3)<span style="font: 7pt "Times New Roman";"> </span></span></b><b>Other considerations</b></div><div class="MsoNormal" style="margin-left: 117pt; text-indent: -0.25in;"><span>a.<span style="font: 7pt "Times New Roman";"> </span></span>S. typhi – even a few colonies are significant</div><div class="MsoNormal" style="margin-left: 117pt; text-indent: -0.25in;"><span>b.<span style="font: 7pt "Times New Roman";"> </span></span>Suprapubic aspirate) less than 10<sup>5</sup>/ml is significant<span> </span>Ureteric samples<span> </span>)</div><div class="MsoNormal" style="margin-left: 117pt; text-indent: -0.25in;"><span>c.<span style="font: 7pt "Times New Roman";"> </span></span>Candida spp – important in diabetics and immunosuppressed patients</div><div class="MsoNormal" style="margin-left: 117pt; text-indent: -0.25in;"><span>d.<span style="font: 7pt "Times New Roman";"> </span></span>*Pseudomonas species….</div><div class="MsoNormal"><br />
</div><div class="MsoNormal" style="margin-left: 37.5pt; text-indent: -19.5pt;"><b><span>(4)<span style="font: 7pt "Times New Roman";"> </span></span></b><b>Mixed growth</b></div><div class="MsoNormal" style="margin-left: 117pt; text-indent: -0.25in;"><span>a.<span style="font: 7pt "Times New Roman";"> </span></span>Significant growth of only two types of colonies identify and do sensitivity test.</div><div class="MsoNormal" style="margin-left: 117pt; text-indent: -0.25in;"><span>b.<span style="font: 7pt "Times New Roman";"> </span></span>More than two types of colonies, ask for a repeat specimen</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>Identification/Sensitivity Tests</b></div><div class="MsoNormal"><b>Some Common Pathogens</b></div><div class="MsoNormal"><br />
</div><table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-collapse: collapse; border: medium none;"><tbody>
<tr> <td style="border: 1pt solid windowtext; padding: 0in 5.4pt; width: 95.4pt;" valign="top" width="127"> <div class="MsoNormal"><b>Organism</b></div></td> <td style="border-color: windowtext windowtext windowtext -moz-use-text-color; border-style: solid solid solid none; border-width: 1pt 1pt 1pt medium; padding: 0in 5.4pt; width: 81pt;" valign="top" width="108"> <div class="MsoNormal"><b>Gram Result</b></div></td> <td style="border-color: windowtext windowtext windowtext -moz-use-text-color; border-style: solid solid solid none; border-width: 1pt 1pt 1pt medium; padding: 0in 5.4pt; width: 128.65pt;" valign="top" width="172"> <div class="MsoNormal"><b>Test(s)</b></div></td> <td style="border-color: windowtext windowtext windowtext -moz-use-text-color; border-style: solid solid solid none; border-width: 1pt 1pt 1pt medium; padding: 0in 5.4pt; width: 110.7pt;" valign="top" width="148"> <div class="MsoNormal"><b>*<span> </span>* Sensitivity</b></div></td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 95.4pt;" valign="top" width="127"> <div class="MsoNormal"><span style="font-size: 10pt;">E. coli, Klebsiella </span></div><div class="MsoNormal"><span style="font-size: 10pt;">Enterobacter</span></div><div class="MsoNormal"><span style="font-size: 10pt;">Citrobacter & Other</span></div><div class="MsoNormal"><span style="font-size: 10pt;">Coliforms</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 81pt;" valign="top" width="108"> <div class="MsoNormal"><span style="font-size: 10pt;">GNR (LFs)</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 128.65pt;" valign="top" width="172"> <div class="MsoNormal"><span style="font-size: 10pt;">Indole, Urea Citrate, TSI</span></div><div class="MsoNormal"><span style="font-size: 10pt;">Motility Tests or consider</span></div><div class="MsoNormal"><span style="font-size: 10pt;">direct API 20E</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 110.7pt;" valign="top" width="148"> <div class="MsoNormal"><span style="font-size: 10pt;">Ampicillin, Tetracycline Nalidixic Acid,</span></div><div class="MsoNormal"><span style="font-size: 10pt;">Nitrofurantoin Pipedidic Acid, Septrin </span></div><div class="MsoNormal"><span style="font-size: 10pt;">Gentamicin, Cefuroxime, Augmentin</span></div></td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 95.4pt;" valign="top" width="127"> <div class="MsoNormal"><span style="font-size: 10pt;">Pseudomonas spp</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 81pt;" valign="top" width="108"> <div class="MsoNormal"><span style="font-size: 10pt;">GNR (NLFS0</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 128.65pt;" valign="top" width="172"> <div class="MsoNormal"><span style="font-size: 10pt;">Oxidase, motility</span></div><div class="MsoNormal"><span style="font-size: 10pt;">Non-fermenter of Sugars, or</span></div><div class="MsoNormal"><span style="font-size: 10pt;">Consider direct API 20E</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 110.7pt;" valign="top" width="148"> <div class="MsoNormal"><span style="font-size: 10pt;">Gentamicin, Noroxin, Cefotaxime,</span></div><div class="MsoNormal"><span style="font-size: 10pt;">Ofloxacin Ceftazidime, Amikacin</span></div><div class="MsoNormal"><span style="font-size: 10pt;">Urotractin, ciprofloxacin</span></div></td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 95.4pt;" valign="top" width="127"> <div class="MsoNormal"><span style="font-size: 10pt;">Salmonella spp</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 81pt;" valign="top" width="108"> <div class="MsoNormal"><span style="font-size: 10pt;">GNR</span></div><div class="MsoNormal"><span style="font-size: 10pt;">(NLFs)</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 128.65pt;" valign="top" width="172"> <div class="MsoNormal"><span style="font-size: 10pt;">Indole, Urea Citrate TSI,</span></div><div class="MsoNormal"><span style="font-size: 10pt;">Motality or Consider direct</span></div><div class="MsoNormal"><span style="font-size: 10pt;">Using specific antisera</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 110.7pt;" valign="top" width="148"> <div class="MsoNormal"><span style="font-size: 10pt;">Chloramphenicol, Cefuroxime</span></div><div class="MsoNormal"><span style="font-size: 10pt;">Angmentin, Nalidixic Acid, Noroxin,</span></div><div class="MsoNormal"><span style="font-size: 10pt;">Urotractin Gentamicin, Cefuroxime</span></div><div class="MsoNormal"><span style="font-size: 10pt;">Nitrofurantoin, Ampicilin</span></div></td> </tr>
<tr> <td style="border-color: -moz-use-text-color windowtext windowtext; border-style: none solid solid; border-width: medium 1pt 1pt; padding: 0in 5.4pt; width: 95.4pt;" valign="top" width="127"> <div class="MsoNormal"><span style="font-size: 10pt;">Faecal Streptococcus</span></div><div class="MsoNormal"><span style="font-size: 10pt;">(enterococci)</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 81pt;" valign="top" width="108"> <div class="MsoNormal"><span style="font-size: 10pt;">GPC (Chains)</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 128.65pt;" valign="top" width="172"> <div class="MsoNormal"><span style="font-size: 10pt;">Catalase test, Growth on </span></div><div class="MsoNormal"><span style="font-size: 10pt;">MacConkey</span></div></td> <td style="border-color: -moz-use-text-color windowtext windowtext -moz-use-text-color; border-style: none solid solid none; border-width: medium 1pt 1pt medium; padding: 0in 5.4pt; width: 110.7pt;" valign="top" width="148"> <div class="MsoNormal"><span style="font-size: 10pt;">As above</span></div></td> </tr>
</tbody></table><div class="MsoNormal"><br />
</div><div class="MsoNormal">**<span> </span>Alternatively, use available multodisc for Gram negatives or Gram positives</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>Reporting</b></div><div class="MsoNormal"><span> </span><b><span> </span>I. Significant growth</b></div><div class="MsoNormal" style="margin-left: 1in;">Must be reported with sensitivities as follows</div><div class="MsoNormal" style="margin-left: 1in;"><br />
</div><div class="MsoNormal" style="margin-left: 1.25in; text-indent: -0.25in;"><span>1.<span style="font: 7pt "Times New Roman";"> </span></span><b>Out patients</b><span> </span>- Report oral antibiotics only and keep the Sensitivity of parenteral ones on the request forms.</div><div class="MsoNormal" style="margin-left: 1.25in; text-indent: -0.25in;"><span>2.<span style="font: 7pt "Times New Roman";"> </span></span><b>In-patients</b> – Report both parenteral and oral antibiotics.</div><div class="MsoNormal" style="margin-left: 1.25in;">List of antibiotics will be amended from time to time, depending on availability.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal" style="margin-left: 0.75in; text-indent: -0.5in;"><b><span>II.<span style="font: 7pt "Times New Roman";"> </span></span></b><b>No significant growth.</b></div><div class="MsoNormal" style="margin-left: 0.25in;"><br />
</div><div class="MsoNormal" style="margin-left: 0.75in; text-indent: -0.5in;"><b><span>III.<span style="font: 7pt "Times New Roman";"> </span></span></b><b>Mixed growth</b></div><div class="MsoNormal" style="margin-left: 1in; text-indent: -0.25in;"><span>a.<span style="font: 7pt "Times New Roman";"> </span></span>Significant growth of 2 types of organisms – report with sensitivity</div><div class="MsoNormal" style="margin-left: 1in; text-indent: -0.25in;"><span>b.<span style="font: 7pt "Times New Roman";"> </span></span>More than 2 types of organisms, report as mixed growth.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal" style="margin-left: 1in;"><b>Repeat culture requested</b>. </div><div class="MsoNormal" style="margin-left: 1in;">BY BMS DZAMESI </div></div>Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-3973389828232632821.post-17901926124144030802011-05-31T15:41:00.001-07:002020-09-06T16:44:56.975-07:00haematological profile of people living with pulmonary tuberculosis- a project carried in Ghana<div dir="ltr" style="text-align: left;" trbidi="on"><br />
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<m:smallfrac m:val="off"> <m:dispdef> <m:lmargin m:val="0"> <m:rmargin m:val="0"> <m:defjc m:val="centerGroup"> <m:wrapindent m:val="1440"> <m:intlim m:val="subSup"> <m:narylim m:val="undOvr"> </m:narylim></m:intlim> </m:wrapindent> </m:defjc></m:rmargin></m:lmargin></m:dispdef></m:smallfrac><br />
<div align="center" class="MsoNormal" style="line-height: 200%; text-align: center;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">CHAPTER ONE</span></b></div><div align="center" class="MsoNormal" style="line-height: 200%; text-align: center;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">INTRODUCTION</span></b></div><div class="MsoListParagraph" style="line-height: 200%; margin-left: 0.25in; text-align: justify; text-indent: -0.25in;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">1.1.</span></b><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> BACKGROUND OF THE STUDY</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Pulmonary tuberculosis (TB) is a contagious bacterial infection that mainly involves the lungs, but may spread to other organs and is caused by the bacteria <i>Mycobacterium tuberculosis (M. tuberculosis) </i>(Sauders, 2007). One can get TB by breathing in air droplets from a cough or sneeze of an infected person. This is called primary tuberculosis.</span><span style="color: #cccccc; font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> </span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"></span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">In Ghana, most people will recover from primary TB infection without further evidence of the disease. The infection may stay asleep or inactive (dormant) for years. However, in some people it can reactivate (Ghana Health Service (GHS) publications, 2000). Most people who develop symptoms of a TB infection first became infected in the past (Southwick, 2007). However in some cases the disease may become active in some few weeks after primary infection. In Ghana, there are approximately 10 cases of TB per 100,000 people. However, rates vary dramatically by area of residence and socioeconomic class (G.H.S publications, 2000). </span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The following people are at high risk for active tuberculosis: elderly, infants and people with weaken immune system, for instance, AIDS. The risk for contracting TB increases if one is in frequent contact with people living with the disease, poor nutrition and living in crowded or unsanitary living condition (Southwick, 2007).</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The following factors may increase the rate of TB infection in a population: Increase in HIV infections, increase in number of homeless people (poor environment and nutrition), and the appearance of drug-resistant strains of TB (Southwick, 2007).</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The primary stage of the disease usually doesn't cause symptoms. When symptoms of pulmonary TB occur, they may include: cough (sometimes producing phlegm), coughing up blood, excessive sweating, especially at night, fatigue, fever, unintentional weight loss. Other symptoms that may occur with this disease are breathing difficulty, chest pain, wheezing. Examination may show clubbing of the fingers or toes (in people with advanced disease), enlarged or tender lymph nodes in the neck or other areas, fluid around a lung, unusual breath sounds (crackles) (Southwick, 2007).</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Tests that may be used in the diagnosis of this disease include biopsy of the affected tissue (rare), bronchoscopy, chest CT scan, chest x-ray, sputum examination and cultures, tuberculin skin test. Tuberculosis prevention and control takes two parallel approaches. In the first, people with tuberculosis and their contacts are identified and then treated. Identification of infections often involves testing high-risk groups for tuberculosis. In the second approach, children are vaccinated to protect them from tuberculosis. No vaccine is available that provides reliable protection for adults. However, in tropical areas where the levels of other species of mycobacterium are high, exposure to nontuberculous mycobacterium gives some protection against tuberculosis (Fine <i>et al.,</i> 2001). Many countries use Bacillus Calmette-Guérin (BCG) vaccine as part of their TB control program, especially for infants. According to the WHO in 1993, this is the most often used vaccine worldwide, with 85% of infants in 172 countries immunized in 1993. This was the first vaccine for TB and developed at the Pasteur Institute in France between 1905 and 1921. However, mass vaccination with BCG did not start until after World War II. The protective efficacy of BCG for preventing serious forms of TB (e.g. meningitis) in children is greater than 80%; its protective efficacy for preventing pulmonary TB in adolescents and adults is variable, ranging from 0 to 80%. In South Africa, the country with the highest prevalence of TB, BCG is given to all children under age three. However, BCG is less effective in areas where mycobacterium is less prevalent; therefore BCG is not given to the entire population in these countries. In the USA, for example, BCG vaccine is not recommended except for people who meet specific criteria (W.HO, 2000).</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The World Health Organization (WHO) declared tuberculosis a global health emergency in 1993, and the Stop TB Partnership developed a Global Plan to Stop Tuberculosis that aims to save 14 million lives between 2006 and 2015. Since humans are the only host of <i>Mycobacterium tuberculosis</i>, eradication would be possible. This goal would be helped greatly by an effective vaccine.</span> </div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">BCG provides some protection against severe forms of pediatric TB, but has been shown to be unreliable against adult pulmonary TB, which accounts for most of the disease burden worldwide. Currently, there are more cases of TB on the planet than at any other time in history and most agree there is an urgent need for a newer, more effective vaccine that would prevent all forms of TB—including drug resistant strains—in all age groups and among people with HIV (Southwick, 2007). Several new vaccines to prevent TB infection are being developed. The first recombinant tuberculosis vaccine rBCG30, entered clinical trials in the United States in 2004, sponsored by the National Institute of Allergy and Infectious Diseases (NIAID). A 2005 study showed that a DNA TB vaccine given with conventional chemotherapy can accelerate the disappearance of bacteria as well as protect against re-infection in mice; it may take four to five years to be available in humans (W.H.O, 2005). A very promising TB vaccine, MVA85A, is currently in phase II trials in South Africa by a group led by Oxford University, and is based on a genetically modified vaccinia virus (W.H.O, 2005). In treatment, the goal is to cure the infection with drugs that fight the TB bacteria. Treatment of active pulmonary TB will always involve a combination of many drugs (usually four drugs). All of the drugs are continued until lab tests show which medicines work best. The most commonly used drugs include Isoniazid, Rifampin, Pyrazinamide, and Ethambutol (Southwick, 2007).</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">In other concept, haematological profile are those parameters of the blood forms (red blood cells, white blood cells and platelets) with normal range or value as reference for any value to know whether or not they are normal (Hoffbrand <i>et al.,</i> 2005).Therefore there is the need to know those parameters of the blood which are abnormal in patients living with pulmonary tuberculosis. The erythrocyte sedimentation rate and few of red and white cell indices would be considered. It is true that when one gets infected with pulmonary tuberculosis there is some level of changes which occurs in the blood because it is a bacterial infection. These changes need to be looked at and the extent considered. </span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">In the final concept, the setting for this study is the District Hospital in Cape Coast which is the Cape Coast Metropolitan Hospital. Patients with pulmonary tuberculosis visiting this hospital and those admitted in the hospital are the objects for this study. This means the study is based on patients identified already as pulmonary T.B patients.</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><br />
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</div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">1.2 PROBLEM STATEMENT</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Pulmonary tuberculosis is a major public health concern in Ghana. In Ghana, there are approximately 10 cases of TB per 100,000 people. However, rates vary dramatically by area of residence and socioeconomic class (G.H.S publications, 2000). The continuous spread of TB, requires effort to know: what the haematological profile of the people living with pulmonary tuberculosis are, what abnormal changes occur in these haematological parameters, what effect age and sex have on these haematological parameters of the patients.</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">1.3 JUSTIFICATION OF RESEARCH</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Looking at the continuous spread and mode of transmission of this disease resulting into haematological changes in the patient, there is therefore the need to check the haematological profile of patients in order to treat underlining haematological changes as a result of pulmonary T.B alongside the treatment of the disease itself. </span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">1.4 HYPOTHESIS</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">People living with pulmonary tuberculosis may have abnormal changes in their haematological parameters. It is expected that these changes may be identified in this research in order to be treated alongside the treatment of the <i>Mycobacterium tuberculosis.</i></span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><br />
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</div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">1.5 OBJECTIVES</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">1.5.1 GENERAL OBJECTIVE </span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">To analyze the haematological profile of people living with pulmonary tuberculosis attending the district hospital, Cape Coast.</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoListParagraphCxSpFirst" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify; text-indent: -0.5in;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">1.5.2<span style="font: 7pt "times new roman";"> </span></span></b><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">SPECIFIC OBJECTIVES</span></b></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 200%; margin: 0in 0in 0.0001pt 0.25in; text-align: justify; text-indent: -0.25in;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">1.<span style="font: 7pt "times new roman";"> </span></span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">To determine the abnormal changes that occurs in the haematological parameters (FBC indices, erythrocyte sedimentation rates, ESR) of pulmonary tuberculosis patients.</span></div><div class="MsoListParagraphCxSpLast" style="line-height: 200%; margin: 0in 0in 0.0001pt 0.25in; text-align: justify; text-indent: -0.25in;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">2.<span style="font: 7pt "times new roman";"> </span></span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">To know the effect of age and sex on the haematological indices of pulmonary tuberculosis patients.</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><br />
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</div><div align="center" class="MsoNormal" style="line-height: 200%; text-align: center;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">CHAPTER TWO</span></b></div><div align="center" class="MsoNormal" style="line-height: 200%; text-align: center;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">LITERATURE REVIEW</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">2.1 TUBERCULOSIS (T.B)</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Tuberculosis or TB (short for tubercles bacillus) is a common and often deadly infectious disease caused by various strains of mycobacterium, usually <i>Mycobacterium tuberculosis</i> in humans (Kumar <i>et al.,</i> 2007).Tuberculosis usually attacks the lungs but can also affect other parts of the body. It is spread through the air when people who have the disease cough, sneeze, or spit (Konstantinos, 2010). Most infections in humans result in an asymptomatic, latent infection, and about one in ten latent infections eventually progresses to active disease which, if left untreated, kills more than 50% of its victims.</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The classic symptoms are a chronic cough with blood-tinged sputum, fever, night sweats, and weight loss. Infection of other organs causes a wide range of symptoms. Diagnosis relies on radiology (commonly chest X-rays), a tuberculin skin test, blood tests, as well as microscopic examination and microbiological culture of bodily fluids. Treatment is difficult and requires long courses of multiple antibiotics. Contacts are also screened and treated if necessary (Kumar <i>et al.,</i> 2007). Antibiotic resistance is a growing problem in (extensively) multi-drug-resistant tuberculosis. Prevention relies on screening programs and vaccination, usually with Bacillus Calmette-Guérin vaccine. A third of the world's populations are thought to be infected with M. tuberculosis, (Jasmer <i>et al.,</i> 2002) and new infections occur at a rate of about one per second. The proportion of people who become sick with tuberculosis each year is stable or falling worldwide but, because of population growth, the absolute number of new cases is still increasing (W.H.O, 2007).</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> In 2007 there were an estimated 13.7 million chronic active cases, 9.3 million new cases, and 1.8 million deaths, mostly in developing countries (W.H.O, 2009). In addition, more people in the developed world are contracting tuberculosis because their immune systems are compromised by immunosuppressive drugs, substance abuse, or AIDS. </span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The distribution of tuberculosis is not uniform across the globe; about 80% of the population in many Asian and African countries test positive in tuberculin tests, while only 5-10% of the US population test positive.</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">2.1.1 ORIGIN OF TUBERCULOSIS</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Tuberculosis has been present in humans since antiquity. The earliest unambiguous detection of Mycobacterium tuberculosis is in the remains of bison dated 18,000 years before the present (Rothschild <i>et al.,</i> 2001).Whether tuberculosis originated in cattle and then transferred to humans, or diverged from a common ancestor infecting a different species, is currently unclear (Pearce-Duvet, 2006). However, it is clear that <i>M. tuberculosis</i> is not directly descended from <i>M. bovis</i>, which seems to have evolved relatively recently (Ernst <i>et al.,</i> 2007).Skeletal remains from a Neolithic Settlement in the Eastern Mediterranean show prehistoric humans (7000 BC) had TB, (Hershkovitz <i>et al.,</i> 2008) and tubercular decay has been found in the spines of mummies from 3000–2400 BC (Zink et al, 2003). Phthisis is a Greek term for tuberculosis; around 460 BC, Hippocrates identified phthisis as the most widespread disease of the times involving coughing up blood and fever, which was almost always fatal (Hippocrates, 2006)</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> In South America, the earliest evidence of tuberculosis is associated with the Paracas-Caverna culture (circa 750 BC to circa 100 AD) (Konomi <i>et al.,</i> 2002). In the past, tuberculosis has been called consumption, because it seemed to consume people from within, with a bloody cough, fever, pallor, and long relentless wasting. Other names included phthisis (Greek for consumption) and phthisis pulmonalis; scrofula (in adults), affecting the lymphatic system and resulting in swollen neck glands; tabes mesenterica, TB of the abdomen and lupus vulgaris, TB of the skin; wasting disease; white plague, because sufferers appear markedly pale; king's evil, because it was believed that a king's touch would heal scrofula; and Pott's disease, or gibbus of the spine and joints. Miliary tuberculosis—now commonly known as disseminated TB—occurs when the infection invades the circulatory system, resulting in millet-like seeding of TB bacilli in the lungs as seen on an X-ray (Encyclopedia Britannica, 2006). TB is also called Koch's disease, after the scientist Robert Koch (Ernst <i>et al.,</i> 2007).</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Before the Industrial Revolution, tuberculosis may sometimes have been regarded as vampirism. When one member of a family died from it, the other members that were infected would lose their health slowly. People believed that this was caused by the original victim draining the life from the other family members. Furthermore, people who had TB exhibited symptoms similar to what people considered to be vampire traits. People with TB often have symptoms such as red, swollen eyes (which also creates a sensitivity to bright light), pale skin, extremely low body heat, a weak heart and coughing blood, suggesting the idea that the only way for the afflicted to replenish this loss of blood was by sucking blood (Sledzik, 1994). Another folk belief told that the affected individual was being forced, nightly, to attend fairy revels, so that the victim wasted away owing to lack of rest; this belief was most common when a strong connection was seen between the fairies and the dead (Katharine, 1976).</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Similarly, but less commonly, it was attributed to the victims being "hagridden"—being transformed into horses by witches (hags) to travel to their nightly meetings, again resulting in a lack of rest (Katharine, 1976). TB was romanticized in the nineteenth century. Many people believed TB produced feelings of euphoria referred to as Spes phthisica ("hope of the consumptive"). It was believed that TB sufferers who were artists had bursts of creativity as the disease progressed. It was also believed that TB sufferers acquired a final burst of energy just before they died that made women more beautiful and men more creative (Lawlor, 2003). In the early 20th century, some believed TB to be caused by masturbation (Laumann <i>et al.,</i> 1994). The study of tuberculosis, sometimes known as phthisiatry, dates back to The Canon of Medicine written by Ibn Sina (Avicenna) in the 1020s. He was the first physician to identify pulmonary tuberculosis as a contagious disease, the first to recognize the association with diabetes, and the first to suggest that it could spread through contact with soil and water (Al-Sharrah, 2003). </span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">He developed the method of quarantine in order to limit the spread of tuberculosis (Al-Sharrah, 2003). In ancient times, treatments focused on sufferers' diets. Pliny the Elder described several methods in his Natural History: "wolf's liver taken in thin wine, the lard of a sow that has been fed upon grass, or the flesh of a she-ass taken in broth" (Al-Sharrah, 2003)</span>.</div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Although it was established that the pulmonary form was associated with "tubercles" by Dr Richard Morton in 1689, due to the variety of its symptoms, TB was not identified as a single disease until the 1820s and was not named "tuberculosis" until 1839 by J. L. Schönlein (Konomi <i>et al.,</i> 2002). During the years 1838 – 1845, Dr. John Croghan, the owner of Mammoth Cave, brought a number of tuberculosis sufferers into the cave in the hope of curing the disease with the constant temperature and purity of the cave air; they died within a year. The first TB sanatorium opened in 1854 in Görbersdorf, Germany (today Sokołowsko, Poland) by Hermann Brehmer (Konomi <i>et al.,</i> 2002).</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The bacillus causing tuberculosis, <i>Mycobacterium tuberculosis</i>, was identified and described on 24 March 1882 by Robert Koch. He received the Nobel Prize in physiology or medicine in 1905 for this discovery. Koch did not believe that bovine (cattle) and human tuberculosis were similar, which delayed the recognition of infected milk as a source of infection. Later, this source was eliminated by the pasteurization process. Koch announced a glycerin extract of the tubercle bacilli as a remedy for tuberculosis in 1890, calling it "tuberculin". It was not effective, but was later adapted as a test for pre-symptomatic tuberculosis (Ernst<i> et al.,</i> 2007). The first genuine success in immunizing against tuberculosis was developed from attenuated bovine-strain tuberculosis by Albert Calmette and Camille Guérin in 1906. It was called "BCG" (Bacillus of Calmette and Guérin). The BCG vaccine was first used on humans in 1921 in France, but it was not until after World War II that BCG received widespread acceptance in the USA, Great Britain, and Germany (Comstock, 1994). Tuberculosis, or "consumption" as it was commonly known, caused the most widespread public concern in the 19th and early 20th centuries as an endemic disease of the urban poor. In 1815, one in four deaths in England was of consumption; by 1918 one in six deaths in France were still caused by TB. In the 20th century, tuberculosis killed an estimated 100 million people (Bannon <i>et al.,</i> 1999). After the establishment in the 1880s that the disease was contagious, TB was made a notifiable disease in Britain; there were campaigns to stop spitting in public places, and the infected poor were pressured to enter sanatoria that resembled prisons; the sanatoria for the middle and upper classes offered excellent care and constant medical attention (Comstock, 1994). </span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Whatever the purported benefits of the fresh air and labor in the sanatoria, even under the best conditions, 50% of those who entered were dead within five years (1916) (Comstock, 1994).</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The promotion of Christmas Seals began in Denmark during 1904 as a way to raise money for tuberculosis programs. It expanded to the United States and Canada in 1907 – 1908 to help the National Tuberculosis Association (later called the American Lung Association).In the United States, concern about the spread of tuberculosis played a role in the movement to prohibit public spitting except into spittoons. In Europe, deaths from TB fell from 500 out of 100,000 in 1850 to 50 out of 100,000 by 1950. Improvements in public health were reducing tuberculosis even before the arrival of antibiotics. The disease remained such a significant threat to public health, that when the Medical Research Council was formed in Britain in 1913, its initial focus was tuberculosis research (Bannon <i>et al.,</i> 1999). It was not until 1946 with the development of the antibiotic streptomycin that effective treatment and cure became possible. Prior to the introduction of this drug, the only treatment besides sanatoria were surgical interventions, including bronchoscopy and suction as well as the pneumothorax or plombage technique — collapsing an infected lung to "rest" it and allow lesions to heal — a technique that was of little benefit and was mostly discontinued by the 1950s (Bannon <i>et al.,</i> 1999). </span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The emergence of multidrug-resistant TB has again introduced surgery as part of the treatment for these infections. Here, surgical removal of chest cavities will reduce the number of bacteria in the lungs, as well as increasing the exposure of the remaining bacteria to drugs in the bloodstream. It is therefore thought to increase the effectiveness of the chemotherapy. Hopes that the disease could be completely eliminated have been dashed since the rise of drug-resistant strains in the 1980s. For example, tuberculosis cases in Britain, numbering around 117,000 in 1913, had fallen to around 5,000 in 1987, but cases rose again, reaching 6,300 in 2000 and 7,600 cases in 2005 (Ernst <i>et al.,</i> 2007).</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Due to the elimination of public health facilities in New York and the emergence of HIV, there was a resurgence of TB in the late 1980s. The number of patients failing to complete their course of drugs is high. New York had to cope with more than 20,000 TB patients with multidrug-resistant strains (resistant to, at least, both Rifampin and Isoniazid).The resurgence of tuberculosis resulted in the declaration of a global health emergency by the World Health Organization (WHO) in 1993. Every year, nearly half a million new cases of multidrug-resistant tuberculosis (MDR-TB) are estimated to occur worldwide (Al-Sharrah, 2003). Tuberculosis has co-evolved with humans for many thousands of years, and perhaps for several million years. The oldest known human remains showing signs of tuberculosis infection are 9,000 years old. </span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">During this evolution, M. tuberculosis has lost numerous coding and non-coding regions in its genome, losses that can be used to distinguish between strains of the bacteria. The implication is that M. tuberculosis strains differ geographically, so their genetic differences can be used to track the origins and movement of each strain (Al-Sharrah, 2003).</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">2.1.2 CLASSIFICATION</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The current clinical classification system for tuberculosis (TB) is based on the pathogenesis of the disease. </span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> <b>Classification System for TB</b></span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><u><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Class</span></u><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> <u>Type</u> <u>Description</u></span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">0 No TB exposure No history of exposure </span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> Not infected Negative reaction to tuberculin skin test</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">1 TB exposure History of exposure.</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> No evidence of infection Negative reaction to tuberculin skin test. </span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> Ghon complex</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">2 TB infection. No disease Positive reaction to tuberculin skin test</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> Negative bacteriologic studies (if done) </span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> Fibrocaseous cavitary lesion (usually in </span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> upper lobe of lungs)</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">3 TB, clinically active M. tuberculosis cultured (if done)</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> Clinical, bacteriologic, or radiographic </span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> evidence of current disease</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> History of episode(s) of TB</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">4 TB Not clinically active or</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> Abnormal but stable radiographic </span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> findings</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> Positive reaction to the tuberculin skin </span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> test</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> Negative bacteriologic studies (if done)</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> And No clinical or radiographic </span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> evidence of current disease</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">5 TB suspect Diagnosis pending</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> TB disease should be ruled in or out </span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> within 3 months</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">(www.wikipedia.com)</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">2.1.3 SIGNS AND SYMPTOMS</span></b></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">When the disease becomes active, 75% of the cases are pulmonary TB, that is, TB in the lungs. Symptoms include chest pain, coughing up blood, and a productive, prolonged cough for more than three weeks. Systemic symptoms include fever, chills, night sweats, appetite loss, weight loss, pallor, and often a tendency to fatigue very easily (W.H.O, 2007). In the other 25% of active cases, the infection moves from the lungs, causing other kinds of TB, collectively denoted extra pulmonary tuberculosis. This occurs more commonly in immunosuppressed persons and young children. Extrapulmonary infection sites include the pleura in tuberculosis pleurisy, the central nervous system in meningitis, and the lymphatic system in scrofula of the neck, the genitourinary system in urogenital tuberculosis, and bones and joints in Pott's disease of the spine (W.H.O, 2007). </span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">An especially serious form is disseminated TB, more commonly known as miliary tuberculosis. Extrapulmonary TB may co-exist with pulmonary TB as well (Madison, 2001).</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">2.1.4 CAUSES</span></b></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The primary cause of TB, <i>Mycobacterium tuberculosis</i>, is a small aerobic non-motile bacillus. High lipid content of this pathogen accounts for many of its unique clinical characteristics (Cox, 2004).It divides every 16 to 20 hours, an extremely slow rate compared with other bacteria, which usually divide in less than an hour (Cox, 2004). (For example, one of the fastest-growing bacteria is a strain of <i>E. coli</i> that can divide roughly every 20 minutes). Since MTB has a cell wall but lacks a phospholipid outer membrane, it is classified as a Gram-positive bacterium. However, if a Gram stain is performed, MTB either stains very weakly Gram-positive or does not retain dye due to the high lipid & mycolic acid content of its cell wall (Madison, 2001). MTB can withstand weak disinfectants and survive in a dry state for weeks. In nature, the bacterium can grow only within the cells of a host organism, but <i>M. tuberculosis</i> can be cultured in vitro (Parish <i>et al.,</i> 1999). Using histological stains on expectorate samples from phlegm (also called sputum); scientists can identify MTB under a regular microscope. Since MTB retains certain stains after being treated with acidic solution, it is classified as an acid-fast bacillus (AFB) (Madison, 2001).The most common acid-fast staining technique, the Ziehl-Neelsen stain, dyes AFBs a bright red that stands out clearly against a blue background. Other ways to visualize AFBs include an auramine-rhodamine stain and fluorescent microscopy.</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The <i>M. tuberculosis</i> complex includes four other TB-causing mycobacteria: <i>M. bovis</i>, <i>M. africanum</i>, <i>M. Canetti</i> and <i>M. microti</i> (van Soolingen <i>et al.,</i> 1997). <i>M. africanum </i>is not widespread, but in parts of Africa it is a significant cause of tuberculosis (Niemann et al, 2002). <i>M. bovis</i> was once a common cause of tuberculosis, but the introduction of pasteurized milk has largely eliminated this as a public health problem in developed countries (Thoen <i>et al.,</i> 2006). <i>M. canetti</i> is rare and seems to be limited to Africa, although a few cases have been seen in African emigrants (Pfyffer <i>et al.,</i> 1998). <i>M. microti</i> is mostly seen in immunodeficient people, although it is possible that the prevalence of this pathogen has been underestimated (Niemann <i>et al.,</i> 2000).</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Other known pathogenic mycobacterium includes <i>Mycobacterium leprae</i>, <i>Mycobacterium avium</i> and <i>M. kansasii</i>. The last two are part of the nontuberculous mycobacterium (NTM) group. Nontuberculous mycobacterium cause neither TB nor leprosy, but they do cause pulmonary diseases resembling TB. Persons with silicosis have an approximately 30-fold greater risk for developing TB (Restrepo, 2007). Silica particles irritate the respiratory system, causing immunogenic responses such as phagocytosis which consequently results in high lymphatic vessel deposits (Restrepo, 2007). It is this interference and blockage of macrophage function which increases the risk of tuberculosis (Nijland <i>et al.,</i> 2006). Persons with chronic renal failure who are on hemodialysis also have an increased risk: 10—25 times greater than the general population. Persons with diabetes mellitus have a risk for developing active TB that is two to four times greater than persons without diabetes mellitus, and this risk is likely greater in persons with insulin-dependent or poorly controlled diabetes. Other clinical conditions that have been associated with active TB include gastrectomy with attendant weight loss and malabsorption, jejunoileal bypass, renal and cardiac transplantation, carcinoma of the head or neck, and other neoplasms (e.g., lung cancer, lymphoma, and leukemia) (Restrepo, 2007).</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Given that silicosis greatly increases the risk of tuberculosis, more research about the effect of various indoor or outdoor air pollutants on the disease would be necessary. Some possible indoor source of silica includes paint, concrete and Portland cement. Crystalline silica is found in concrete, masonry, sandstone, rock, paint, and other abrasives. The cutting, breaking, crushing, drilling, grinding, or abrasive blasting of these materials may produce fine silica dust. It can also be in soil, mortar, plaster, and shingles. When you wear dusty clothing at home or in your car, you may be carrying silica dust that your family will breathe. </span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Low body weight is associated with risk of tuberculosis as well. A body mass index (BMI) below 18.5 increases the risk by 2—3 times. On the other hand, an increase in body weight lowers the risk (Niobe-Eyangoh <i>et al.,</i> 2003). Patients with diabetes mellitus are at increased risk of contracting tuberculosis, and they have a poorer response to treatment, possibly due to poorer drug absorption (Restrepo <i>et al.,</i> 2007)</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Other conditions that increase risk include IV drug abuse; recent TB infection or a history of inadequately treated TB; chest X-ray suggestive of previous TB, showing fibrotic lesions and nodules; prolonged corticosteroid therapy and other immunosuppressive therapy; Immunocompromised patients (30-40% of AIDS patients in the world also have TB) hematologic and reticuloendothelial diseases, such as leukemia and Hodgkin's disease; end-stage kidney disease; intestinal bypass; chronic malabsorption syndromes; vitamin D deficiency (Nnoaham <i>et al.,</i> 2008); and low body weight (Southwick <i>et al.,</i> 2007). Twin studies in the 1940s showed that susceptibility to TB was heritable. If one of a pair of twins got TB, then the other was more likely to get TB if he was identical than if he was not (Jepson <i>et al.,</i> 2001). These findings were more recently confirmed by a series of studies in South Africa (Jepson et al, 2001). Specific gene polymorphisms in IL12B have been linked to tuberculosis susceptibility (Tso <i>et al.,</i> 2004). Some drugs, including rheumatoid arthritis drugs that work by blocking tumor necrosis factor-alpha (an inflammation-causing cytokine), raise the risk of activating a latent infection due to the importance of this cytokine in the immune defense against TB (Mutlu <i>et al.,</i> 2006).</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">2.1.5 MECHANISM</span></b></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">When people suffering from active pulmonary TB coughs, sneeze, speak, or spit, they expel infectious aerosol droplets 0.5 to 5 µm in diameter. A single sneeze can release up to 40,000 droplets. Each one of these droplets may transmit the disease, since the infectious dose of tuberculosis is very low and inhaling less than ten bacteria may cause an infection (Nicas <i>et al.,</i> 2005). People with prolonged, frequent, or intense contact are at particularly high risk of becoming infected, with an estimated 22% infection rate. A person with active but untreated tuberculosis can infect 10–15 other people per year. Others at risk include people in areas where TB is common, people who inject drugs using unsanitary needles, residents and employees of high-risk congregate settings, medically under-served and low-income populations, high-risk racial or ethnic minority populations, children exposed to adults in high-risk categories, patients immunocompromised by conditions such as HIV/AIDS, people who take immunosuppressant drugs, and health care workers serving these high-risk clients (Cole <i>et al.,</i> 1998). Transmission can only occur from people with active — not latent — TB. The probability of transmission from one person to another depends upon the number of infectious droplets expelled by a carrier, the effectiveness of ventilation, the duration of exposure, and the virulence of the <i>M. tuberculosis</i> strain (Behr <i>et al.,</i> 1999). The chain of transmission can, therefore, be broken by isolating patients with active disease and starting effective anti-tubercles therapy. After two weeks of such treatment, people with non-resistant active TB generally cease to be contagious. If someone does become infected, then it will take at least 21 days, or three to four weeks, before the newly infected person can transmit the disease to others (Jepson <i>et al.,</i> 2001). TB can also be transmitted by eating meat infected with TB. <i>Mycobacterium bovis</i> causes TB in cattle. About 90% of those infected with <i>Mycobacterium tuberculosis</i> have asymptomatic, latent TB infection (sometimes called LTBI), with only a 10% lifetime chance that a latent infection will progress to TB disease. However, if untreated, the death rate for these active TB cases is more than 50% (Sepulveda <i>et al.,</i> 1994).</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">TB infection begins when the mycobacterium reach the pulmonary alveoli, where they invade and replicate within the endosomes of alveolar macrophages (Cobat <i>et al.,</i> 2010). The primary site of infection in the lungs is called the Ghon focus, and is generally located in either the upper part of the lower lobe or the lower part of the upper lobe (Griffith <i>et al.,</i> 1996). Bacteria are picked up by dendritic cells, which do not allow replication, although these cells can transport the bacilli to local (mediastinal) lymph nodes. Further spread is through the bloodstream to other tissues and organs where secondary TB lesions can develop in other parts of the lung (particularly the apex of the upper lobes), peripheral lymph nodes, kidneys, brain, and bone (Houben <i>et al.,</i> 2006). All parts of the body can be affected by the disease, though it rarely affects the heart, skeletal muscles, pancreas and thyroid (Herrmann <i>et al.,</i> 2005). Tuberculosis is classified as one of the granulomatous inflammatory conditions. Macrophages, T lymphocytes, B lymphocytes and fibroblasts are among the cells that aggregate to form a granulomatous, with lymphocytes surrounding the infected macrophages. The granulomatous functions not only to prevent dissemination of the mycobacteria, but also provides a local environment for communication of cells of the immune system. Within the granuloma, T lymphocytes secrete cytokines such as interferon gamma, which activates macrophages to destroy the bacteria with which they are infected (Agarwal <i>et al.,</i> 2005). Cytotoxic T cells can also directly kill infected cells, by secreting perforin and granulysin (Agarwal <i>et al.,</i> 2005). Importantly, bacteria are not always eliminated within the granuloma, but can become dormant, resulting in a latent infection. Another feature of the granulomas of human tuberculosis is the development of abnormal cell death, also called necrosis, in the center of tubercles. To the naked eye this has the texture of soft white cheese and was termed caseous necrosis (Kaufmann, 2002).</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">If TB bacteria gain entry to the bloodstream from an area of damaged tissue they spread through the body and set up many foci of infection, all appearing as tiny white tubercles in the tissues. This severe form of TB disease is most common in infants and the elderly and is called miliary tuberculosis. Patients with this disseminated TB have a fatality rate near 100% if untreated. However, if treated early, the fatality rate is reduced to near 10% (Kaufmann, 2002). In many patients the infection waxes and wanes (Grosset, 2003). Tissue destruction and necrosis are balanced by healing and fibrosis. Affected tissue is replaced by scarring and cavities filled with cheese-like white necrotic material. During active disease, some of these cavities are joined to the air passages bronchi and this material can be coughed up. It contains living bacteria and can therefore pass on infection. Treatment with appropriate antibiotics kills bacteria and allows healing to take place. Upon cure, affected areas are eventually replaced by scar tissue.</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">If untreated, infection with Mycobacterium tuberculosis can become lobar pneumonia (Grosset, 2003).</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">2.1.6 DIAGNOSIS</span></b></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Tuberculosis is diagnosed definitively by identifying the causative organism (Mycobacterium tuberculosis) in a clinical sample (for example, sputum or pus). When this is not possible, a probable - although sometimes inconclusive (Konstantinos, 2010) - diagnosis may be made using imaging (X-rays or scans) and/or a tuberculin skin test (Mantoux test). The main problem with tuberculosis diagnosis is the difficulty in culturing this slow-growing organism in the laboratory (it may take 4 to 12 weeks for blood or sputum culture). A complete medical evaluation for TB must include a medical history, a physical examination, a chest X-ray, microbiological smears, and cultures. It may also include a tuberculin skin test, a serological test. The interpretation of the tuberculin skin test depends upon the person's risk factors for infection and progression to TB disease, such as exposure to other cases of TB or immunosuppressant (Konstantinos, 2010). Currently, latent infection is diagnosed in a non-immunized person by a tuberculin skin test, which yields a delayed hypersensitivity type response to an extract made from M. tuberculosis (Kumar <i>et al.,</i> 2007). Those immunized for TB or with past-cleared infection will respond with delayed hypersensitivity parallel to those currently in a state of infection, so the test must be used with caution, particularly with regard to persons from countries where TB immunization is common(Cox, 2004). Tuberculin tests have the disadvantage of producing false negatives, especially when the patient is co-morbid with sarcoidosis, Hodgkin’s lymphoma, malnutrition, or most notably active tuberculosis disease. The newer interferon release assays (IGRAs) overcome many of these problems. IGRAs are in vitro blood tests that are more specific than the skin test. IGRAs detect the release of interferon gamma in response to mycobacterial proteins such as ESAT-6. These are not affected by immunization or environmental mycobacteria, so generate fewer false positive results (Pai <i>et al.,</i> 2008). There is also evidence that the T-SPOT.TB IGRA is more sensitive than the skin test. Diagnosis of TB has also been done with use of various radiotracers using nuclear medicine methods, which not only detects but also locates tubercular infection (Lavani <i>et al.,</i> 2005). New TB tests are being developed that offer the hope of cheap, fast and more accurate TB testing. These include polymerase chain reaction assays for the detection of bacterial DNA. The development of a rapid and inexpensive diagnostic test would be particularly valuable in the developing world (Reddy <i>et al.,</i> 2002).</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">2.1.7 EPIDEMIOLOGY AND PROGNOSIS</span></b></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: center;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"><img height="489" src="file:///C:/Users/delaTONY/AppData/Local/Temp/msohtmlclip1/01/clip_image002.jpg" width="732" /></span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"></span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Fig. (a)</span></b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> : The prevalence of TB per 100,000 people in sub – Saharan Africa in 2007. </span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">In 2007, the prevalence of TB per 100,000 people was highest in sub-Saharan Africa, and was also relatively high in Asia (W.H.O, 2009).</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: center;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"><img height="458" src="file:///C:/Users/delaTONY/AppData/Local/Temp/msohtmlclip1/01/clip_image004.jpg" width="716" /></span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"></span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Fig. (b):</span></b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> The annual number of new reported cases in the world.</span></div><div align="center" class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: center;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Annual number of new reported TB cases. Data from W.H.O, 2007.</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Roughly a third of the world's population has been infected with <i>M. tuberculosis</i>, and new infections occur at a rate of one per second (W.H.O, 2007). However, not all infections with <i>M. tuberculosis</i> cause TB disease and many infections are asymptomatic. In 2007, an estimated 13.7 million people had active TB disease, with 9.3 million new cases and 1.8 million deaths; the annual incidence rate varied from 363 per 100,000 in Africa to 32 per 100,000 in the Americas. Tuberculosis is the world's greatest infectious killer of women of reproductive age and the leading cause of death among people with HIV/AIDS (W.H.O, 2007).</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The rise in HIV infections and the neglect of TB control programs have enabled a resurgence of tuberculosis (Iademarco <i>et al.,</i> 2003). The emergence of drug-resistant strains has also contributed to this new epidemic with, from 2000 to 2004, 20% of TB cases being resistant to standard treatments and 2% resistant to second-line drugs (Lambert <i>et al.,</i> 2003). The rate at which new TB cases occur varies widely, even in neighboring countries, apparently because of differences in health care systems (Sobero <i>et al.,</i> 2006). In 2007, the country with the highest estimated incidence rate of TB was Swaziland, with 1200 cases per 100,000 people. India had the largest total incidence, with an estimated 2.0 million new cases (W.H.O, 2009). The Philippines ranks fourth in the world for the number of cases of tuberculosis and has the highest number of cases per head in Southeast Asia. Almost two thirds of Filipinos have tuberculosis, and up to an additional five million people are infected yearly (Philippine Department of Health). In developed countries, tuberculosis is less common and is mainly an urban disease. In the United Kingdom, the national average was 15 per 100,000 in 2007, and the highest incidence rates in Western Europe were 30 per 100,000 in Portugal and Spain. These rates compared with 98 per 100,000 in China and 48 per 100,000 in Brazil. In the United States, the overall tuberculosis case rate was 4 per 100,000 persons in 2007 (Sobero <i>et al.,</i> 2006). In Canada tuberculosis is still endemic in some rural areas (Sobero <i>et al.,</i> 2006).</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The incidence of TB varies with age. In Africa, TB primarily affects adolescents and young adults (W.H.O, 2006). However, in countries where TB has gone from high to low incidence, such as the United States, TB is mainly a disease of older people, or of the immunocompromised (Centers for Disease Control and Prevention (CDC), 2006). There are a number of known factors that make people more susceptible to TB infection: worldwide the most important of these is HIV. Co-infection with HIV is a particular problem in Sub-Saharan Africa, due to the high incidence of HIV in these countries (Chaisson <i>et al.,</i> 2008). Smoking more than 20 cigarettes a day also increases the risk of TB by two to four times (Davies <i>et al.,</i> 2006), (Jha <i>et al.,</i> 2008). Diabetes mellitus is also an important risk factor that is growing in importance in developing countries (Restrepo, 2007). Other disease states that increase the risk of developing tuberculosis are Hodgkin lymphoma, end-stage renal disease, chronic lung disease, malnutrition, and alcoholism (Kumar <i>et al.,</i> 2007).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Diet may also modulate risk. For example, among immigrants in London from the Indian subcontinent, vegetarian Hindu Asians were found to have an 8.5 fold increased risk of tuberculosis, compared to Muslims who ate meat and fish daily (Strachan et al, 1995-02). Although a causal link is not proved by this data (Davis, 1995) this increased risk could be caused by micronutrient deficiencies: possibly iron, vitamin B12 or vitamin D (Strachan et al, 1995-02). Further studies have provided more evidence of a link between vitamin D deficiency and an increased risk of contracting tuberculosis (Ustianowski <i>et al.,</i> 2005), (Nnoaham <i>et al.,</i> 2008). Globally, the severe malnutrition common in parts of the developing world causes a large increase in the risk of developing active tuberculosis, due to its damaging effects on the immune system (Schaible <i>et al.,</i> 2007), (Lönnroth <i>et al.,</i> 2008). Along with overcrowding, poor nutrition may contribute to the strong link observed between tuberculosis and poverty (Davies, 2003).</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Prisoners, especially in poor countries, are particularly vulnerable to infectious diseases such as HIV/AIDS and TB. Prisons provide a condition that allows TB to spread rapidly, due to overcrowding, poor nutrition and a lack of health services. Since the early 1990s, TB outbreaks have been reported in prisons in many countries in Eastern Europe. The prevalence of TB in prisons is much higher than among the general population – in some countries as much as 40 times higher (Larouzé <i>et al.,</i> 2008).</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">2.1.8 TREATMENT AND PREVENTION</span></b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"></span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Treatment for TB uses antibiotics to kill the bacteria. Effective TB treatment is difficult, due to the unusual structure and chemical composition of the mycobacterial cell wall, which makes many antibiotics ineffective and hinders the entry of drugs. The two antibiotics most commonly used are rifampicin and Isoniazid (Webber <i>et al.,</i> 2001). However, instead of the short course of antibiotics typically used to cure other bacterial infections, TB requires much longer periods of treatment (around 6 to 24 months) to entirely eliminate mycobacteria from the body. Latent TB treatment usually uses a single antibiotic, while active TB disease is best treated with combinations of several antibiotics, to reduce the risk of the bacteria developing antibiotic resistance. People with latent infections are treated to prevent them from progressing to active TB disease later in life (Barder <i>et al.,</i> 2006).</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Drug resistant tuberculosis is transmitted in the same way as regular TB. Primary resistance occurs in persons who are infected with a resistant strain of TB. A patient with fully susceptible TB develops secondary resistance (acquired resistance) during TB therapy because of inadequate treatment, not taking the prescribed regimen appropriately, or using low quality medication. Drug-resistant TB is a public health issue in many developing countries, as treatment is longer and requires more expensive drugs. Multi-drug-resistant tuberculosis (MDR-TB) is defined as resistance to the two most effective first-line TB drugs: rifampicin and isoniazid. Extensively drug-resistant TB (XDR-TB) is also resistant to three or more of the six classes of second-line drugs (C.D.C, 2006). The DOTS (Directly Observed Treatment Short-course) strategy of tuberculosis treatment recommended by WHO was based on clinical trials done in the 1970s by Tuberculosis Research Centre, Chennai, India. The country in which a person with TB lives can determine what treatment they receive. This is because multidrug-resistant tuberculosis is resistant to most first-line medications, the use of second-line antituberculosis medications is necessary to cure the patient. However, the price of these medications is high; thus poor people in the developing world have no or limited access to these treatments (Dietrich <i>et al.,</i> 2006).</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">TB prevention and control takes two parallel approaches. In the first, people with TB and their contacts are identified and then treated. Identification of infections often involves testing high-risk groups for TB. In the second approach, children are vaccinated to protect them from TB. No vaccine is available that provides reliable protection for adults. However, in tropical areas where the levels of other species of mycobacteria are high, exposure to nontuberculous mycobacteria gives some protection against TB (Fine <i>et al.,</i> 2001). The World Health Organization (WHO) declared TB a global health emergency in 1993, and the Stop TB Partnership developed a Global Plan to Stop Tuberculosis that aims to save 14 million lives between 2006 and 2015 (W.H.O, 2006). Since humans are the only host of <i>Mycobacterium tuberculosis</i>, eradication would be possible. This goal would be helped greatly by an effective vaccine (Martin, 2006).</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">2.2.0 HAEMATOLOGICAL INDICES</span></b></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Haemoglobin is measured to detect anaemia and its severity and to monitor an anaemic patient’s response to treatment. Monitoring the haemoglobin level (or PCV) is also required when patients with HIV disease are being treated with drugs such as AZT. The test is also performed to check the haemoglobin level of a blood donor prior to donating blood (Cheesbrough, 2006). </span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The erythrocyte sedimentation rate (ESR) is a non-specific test. It is raised in a wide range of infectious, inflammatory, degenerative, and malignant conditions associated with changes in plasma proteins, particularly increases in fibrinogen, immunoglobulins, and C-reactive protein. The ESR is also affected by many other factors including anaemia, pregnancy, haemoglobinopathies, haemoconcentration and treatment with anti-inflammatory drugs. Moderately raised sedimentation rates can sometimes be found in healthy people, particularly those living in tropical countries and a ‘normal’ ESR cannot exclude disease. In many tropical countries, ESR measurements have been discontinued because they add little to diagnosing disease, assessing its progress and monitoring response to treatment. When performed, test results must be interpreted in conjunction with clinical findings and the results of other laboratory tests (Cheesbrough, 2006).</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">A white blood cell (WBC) count is used to investigate HIV/AIDS, infections and unexplained fever, and to monitor treatments which can cause leucopenia. In most situations when a total WBC count is requested it is usual to perform also a differential WBC count (Cheesbrough, 2006). The main causes of a raised WBC count (leukocytosis) are: Acute infections e.g. pneumonia, meningitis, abscess, whooping cough, tonsillitis, acute rheumatic fever, septicaemia, gonorrhoea, cholera, septic abortion; acute infections in children can cause a sharp rise in WBC count; Inflammation and tissue necrosis e.g. burns, gangrene, fractures and trauma, arthritis, tumours, acute myocardial infarction; metabolic disorders e.g. eclampsia, uraemia, diabetic coma and acidosis; poisoning e.g. chemicals, drugs, snake venoms; acute haemorrhage; leukaemias and myeloproliferative disorders; stress, menstruation, strenuous exercise (Cheesbrough, 2006). The main causes of a reduced WBC count are: Viral, bacterial, parasitic infections e.g. HIV/AIDS, viral hepatitis, measles, rubella, influenza, rickettsial infections, overwhelming bacterial infections such as miliary tuberculosis, relapsing fever, typhoid, paratyphoid, bucellosis, parasitic infections including leishmaniasis and malaria; drugs (e.g. cytotoxic) and reactions to chemicals; hypersplenism; aplastic anaemia Folate and vitamin B12 deficiencies (megaloblastic anaemia); bone marrow infiltration (e.g. lymphomas, myelofibrosis, myelomatosis); anaphylactic shock; ionizing radiation (Cheesbrough, 2006).</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">In conclusion, pulmonary tuberculosis is a worldwide deadly disease which should be considered and tackled not forgetting other abnormal changes that it brings to the human body thereby tackling those changes too. Pulmonary tuberculosis is a major public health concern in Ghana. In Ghana, there are approximately 10 cases of TB per 100,000 people. However, rates vary dramatically by area of residence and socioeconomic class (G.H.S publications, 2000). The continues spread of TB, requires effort to know: what the haematological profile of the people living with pulmonary tuberculosis are, what abnormal changes occur in these haematological parameters, what effect age and sex have on these haematological parameters of the patients.</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> </span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><br />
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</div><div align="center" class="MsoNormal" style="line-height: 200%; text-align: center;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">CHAPTER THREE</span></b></div><div align="center" class="MsoNormal" style="line-height: 200%; text-align: center;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">METHODOLOGY</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">3.1.0 STUDY AREA AND WHERE RESEARCH WORK WAS UNDERTAKEN</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Pulmonary tuberculosis patients who visited the district hospital (Cape Coast Metropolitan Hospital) in the Cape Coast Municipality in the Central Region of Ghana were the target population for the study. The research work was done in the laboratory within the same hospital.</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">3.1.1. STUDY PERIOD</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The study was conducted between the months of December, 2010 and February, 2011. During this period the samples were taken weekly.</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">3.2.0 ETHICAL CONSIDERATION</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The selection of subjects and the collection of specimens from the subjects was done after prior notice and approval from all protocols involved, was obtained.</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">3.3 SAMPLES, SAMPLING TECHNIQUE AND SIZE</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">A total number of one hundred (100) patients were sampled from the target population randomly. The blood samples only were taken into EDTA tubes using vacutainers for the venipuncture.</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><br />
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</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">3.3.1. SAMPLING</span></b></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The vacutainer method of bloodletting into EDTA tubes was used in sampling the blood. Before the sampling all the necessary materials equipment (gloves, cotton wool, alcohol prep pad, tourniquet, plaster, needle and vacutainer holder) needed were prepared and set.</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">During the sampling, the patients name and age were taken. All specimen tubes were marked with the identification and pull on protective gloves to prevent contact with bodily fluids.</span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> Blood was drawn from the most common point--the median cubital vein--which runs on the inner part of the forearm. This is the optimum vein because it's close to the skin surface and there aren't a lot of nerves surrounding it.</span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> </span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The chosen location was prepped by placing a tourniquet on the upper part of the arm, tight enough to make the vein bulge. The vein was gently patted and its size looked at. The best angle from which to draw the blood was then found.</span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> </span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The needle was inserted into the vein with a smooth, fast motion. This technique lessened the pain. The vacutainer (blood specimen tube) was pushed into the holder, keeping the needle steady. The vacutainer automatically started filling with the right amount of blood needed for the specific specimen. The needle was pulled out at the same angle it was inserted once the specimen was collected. Immediately, after the needle was disposed off properly and cotton applied to the patient's wound, holding it to apply pressure and finally plastered it.</span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> </span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The specimens were mixed thoroughly by gently swishing them around. Confirmation was made that each specimen was labeled correctly.</span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"></span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">3.4.0 LABORATORY AND OR OTHER ACTIVITY</span></b></div><div class="MsoNormal" style="line-height: 150%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The laboratory activities that were carried out for the purpose of the study were the erythrocyte sedimentation rate, ESR (using the westergren method) and the full blood count, FBC (using the Sysmex XT- 20000i analyser).</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">3.5.0 LIMITATIONS</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Due to the lack of interest and state of some patients a large number of pulmonary tuberculosis patients were not sampled for the study.</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">3.6.0 DELIMITATIONS</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The research involved only pulmonary tuberculosis patients who attended the district hospital in the municipality.</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">3.7.0 STATISTICAL TOOL AND ANALYSIS EMPLOYED</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Pie charts and graphs percentages were used. Pie charts and graph where use to represent the values of the raw data taken and analysed using excel.</span></div><div align="center" class="MsoNormal" style="line-height: 200%; text-align: center;"><br />
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</div><div align="center" class="MsoNormal" style="line-height: 200%; text-align: center;"><form action="https://www.alertpay.com/checkout" method="post"><input name="ap_productid" type="hidden" value="" /> <input name="ap_quantity" type="hidden" value="1" /> <input name="ap_image" src="https://www.alertpay.com//PayNow/BB5B823E16424578894079F4B9C94997b0en.gif" type="image" /> </form><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">CHAPTER FOUR</span></b></div><div align="center" class="MsoNormal" style="line-height: 200%; text-align: center;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">RESULTS</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">4.0 RESULTS</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">A total number of one hundred (100) patients were sampled from the target population randomly. The blood samples were taken into EDTA tubes using vacutainer method for the venipuncture.</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">4.1 The haemoglobin parameter studied in the study population.</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Out of the 100 sampled, 62 (62%) had Hb below normal (<11.0g/dl) (anaemic), 38 (38%) had normal Hb (11.0g/dl-18.0g/dl) and none had Hb above normal (>18.0g/dl). </span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"><img height="471" src="file:///C:/Users/delaTONY/AppData/Local/Temp/msohtmlclip1/01/clip_image006.png" width="756" /></span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"></span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Fig 4.1 Haemoglobin parameter studied in the study population</span></b><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"></span></b></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">4.2 The erythrocyte sedimentation rate (ESR) parameter studied in the study population</span></b></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Out of the 100 sampled 6(6%) were within E.S.R value 0-20mm/hr (1), 1(1%) was within the E.S.R value 21-40mm/hr (2), 9(9%) were within the E.S.R value 41-60mm/hr (3), 7(7%) were within the E.S.R value 61-80mm/hr (4), 77(77%) were >80mm/hr (5).</span></div><div align="center" class="MsoNormal" style="line-height: 150%; margin-bottom: 0.0001pt; text-align: center;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 150%;"><img height="276" src="file:///C:/Users/delaTONY/AppData/Local/Temp/msohtmlclip1/01/clip_image008.png" width="756" /></span></b><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 150%;"> Fig 4.2 Erythrocyte sedimentation rate (ESR) parameter studied in the study population</span></b></div><div class="MsoNormal" style="line-height: 150%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 150%; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 150%;">4.3 The total leucocyte count parameter studied in the study population</span></b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 150%;"></span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Out of the 100 sampled, 2(2%) had total leucocyte count below 4.0 * 10^3 / ul, 29 (29%) had normal total leucocyte count and 69 (69%) above 11.0 * 10^3 / ul. </span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: center;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"><img height="339" src="file:///C:/Users/delaTONY/AppData/Local/Temp/msohtmlclip1/01/clip_image010.png" width="746" /></span></b><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> Fig. 4.3 total leucocyte count parameter studied in the study population</span></b></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">4.4 The absolute neutrophil count (A.N.C) parameter studied in the study population</span></b></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Out of the 100 sampled, 3(3%) had A.N.C below 2.5 * 10^3 / ul, 29 (29%) had normal A.N.C and 68 (68%) had A.N.C above 7.5 * 10^3 / ul. </span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"><img height="284" src="file:///C:/Users/delaTONY/AppData/Local/Temp/msohtmlclip1/01/clip_image012.png" width="786" /></span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"></span></div><div align="center" class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt; text-align: center;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">Fig. 4.4 absolute neutrophil count (A.N.C) parameter studied in the study population</span></b></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">4.5 The absolute lymphocyte count parameter studied in the study population</span></b></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Out of the 100 sampled, 17(17%) had absolute lymphocyte count below 1.5 * 10^3 / ul, 80 (80%) had normal absolute lymphocyte count and 3(3%) had absolute lymphocyte count above 3.5 * 10^3 / ul. </span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"><img height="272" src="file:///C:/Users/delaTONY/AppData/Local/Temp/msohtmlclip1/01/clip_image014.png" width="792" /></span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"></span></div><div align="center" class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt; text-align: center;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">Fig. 4.5</span></b><span style="font-family: "Times New Roman","serif"; font-size: 12pt;"> <b>absolute lymphocyte count parameter studied in the study population</b></span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">4.6 The platelet count parameter studied in the study population</span></b></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Out of the 100 sampled, 8(8%) had platelet count below 150 * 10^3 / ul, 49(49%) had normal platelet count and 43(43%) had platelet count above 150 * 10^3 / ul. </span></div><div align="center" class="MsoNormal" style="line-height: 200%; text-align: center;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"><img height="360" src="file:///C:/Users/delaTONY/AppData/Local/Temp/msohtmlclip1/01/clip_image016.png" width="750" /></span></b><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Fig. 4.6</span></b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> <b>platelet count parameter studied in the study population</b></span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">4.7 The percentage of the study population’s sex</span></b></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Out of the 100 sampled, 59(59%) were male and 41(41%) were female. </span></div><div align="center" class="MsoNormal" style="line-height: 200%; text-align: center;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"><img height="360" src="file:///C:/Users/delaTONY/AppData/Local/Temp/msohtmlclip1/01/clip_image018.png" width="776" /></span></b><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Fig. 4.7</span></b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> <b>Percentage of the Study Population’s Sex</b></span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">4.8 The percentages of the study population’s age</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Out of the 100 sampled 4(4%) were within the age range of 10 – 19, 55(55%) were within the age range of 20 – 29, 37(37%) were within the age range of 30 – 39, 4(4%) also were within the age range of 40 – 49, none of the patients were within the age ranges of 0 – 9 and 50 – 59. </span></div><div align="center" class="MsoNormal" style="line-height: 200%; text-align: center;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"><img height="654" src="file:///C:/Users/delaTONY/AppData/Local/Temp/msohtmlclip1/01/clip_image020.png" width="806" /></span></b><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Fig. 4.8</span></b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> <b>Percentages of the Study Population’s Age</b></span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><br />
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</div><div align="center" class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: center;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">CHAPTER FIVE</span></b></div><div align="center" class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: center;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">5.0 DISCUSSION, CONCLUSION AND RECOMMENDATION</span></b></div><div class="MsoNormal" style="line-height: 200%;"><br />
</div><div class="MsoNormal" style="line-height: 200%;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">5.1. DISCUSSION</span></b></div><div class="MsoNormal" style="line-height: 200%;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Based on the results obtained from the study carried out on 100 pulmonary T.B patients between the ages of 1 and 66 in the Cape Coast Metropolitan Hospital, of which 59 subjects were males and 41 females, the following assertions were made.</span></div><h1 style="line-height: 200%; text-align: justify;"><span style="font-size: 12pt; font-weight: normal; line-height: 200%;">In a research carried out on Haematological profile of patients with pulmonary tuberculosis in Ibadan, Nigeria, it was found that the haematological indices of sixty two pre-treatment, sputum-smear-AFB positive pulmonary tuberculosis patients were examined. Haematocrit, white cell count and differentials and erythrocyte sedimentation rates (ESR) were estimated by manual methods. Statistically significant heamatologic abnormalities found include high erythrocyte sedimentation rate (ESR), anaemia occurred in 93.6%, leucocytosis in 22.3%, neutrophilia in 45.2% and lymphopaenia in 4.8% of the patients. Thrombocytosis occurred in 12.9%, while 8% had thrombocytopaenia. None of the patients had leucopaenia and only 8.4% had lymphocytosis (Olaniyi <i>et al.,</i> 2003).</span></h1><div style="background: none 0% 0% repeat scroll white; line-height: 200%; text-align: justify;"><span style="font-weight: normal;">Also another research carried out on the haematological abnormalities in pulmonary tuberculosis in Hungary revealed </span><span style="font-weight: normal;">the extent and severity of haematological abnormalities which occurred in 380 patients with pulmonary tuberculosis. Full blood count, bone marrow aspiration smears, and bone marrow trephine biopsy was analyzed by authors. Anaemia was present in 32% of patients. Leucocytosis with neutrophilia occurred in 18%. Leucopenia with neutropenia, and lymphopaenia was observed in 16% in patients with very severe clinical tuberculosis. Elevated platelet count occurred in 8% with deep vein thrombosis in legs in 50%. There was a close correlation between the haematological abnormalities and the severity of clinical findings of pulmonary tuberculosis. This survey has revealed that haematological abnormalities are relatively common in severe pulmonary tuberculosis. It seems that body weight loss, white blood cell count, haemoglobin level and erythrocyte sedimentation rate are useful indices of severity of the tuberculosis. The return of these indices to a normal level is a good indication of disease control in that they correlate with sputum conversion to acid-fast bacilli negative (</span><span style="font-weight: normal;">Bozóky <i>et al., </i>1997</span><span style="font-weight: normal;">).</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Anaemia occurs when the Hb of an individual falls below normal (11.0g/dl). Anaemia occurs in different forms, with anaemia due to chronic disease such as tuberculosis (Cheesbrough, 2006) considered here. With this, leucocytes changes reflect the condition (Cheesbrough, 2006). Therefore, high leucocyte changes with low Hb reflect anaemia due to chronic condition such as tuberculosis. Increase in leucocytes count may also be as a result of increase in neutrophil count (Cheesbrough, 2006). In bacterial infections, neutrophil counts are increased (Cheesbrough, 2006). This may count for neutrophilia in most patients as <i>Mycobacterium tuberculosis</i> is a bacteria. Infection such as tuberculosis may lead to thrombocytosis as well as thrombocytopenia (Cheesbrough, 2006). Pulmonary tuberculosis (TB) is a contagious bacterial infection caused by the bacteria <i>Mycobacterium tuberculosis (M. tuberculosis) </i>(Saunders, 2007). Significantly raised erythrocyte sedimentation rate can be caused by infection such as tuberculosis (Cheesbrough, 2006). The incidence of TB varies with age. In Africa, TB primarily affects adolescents and young adults (W.H.O, 2006)</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The figures (4.1, 4.2, 4.3, 4.4, 4.5, 4.6, 4.7, and 4.8) above show the percentage of patients who fall below and above the normal ranges of each haematological profile (i.e., the percentage of patients with abnormal haematological changes) and also the percentages of the age and sex of the study population. In fig. 4.1, </span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">out of the 100 sampled, 62 (62%) had Hb below normal (anaemic), 38 (38%) had normal Hb and none had Hb above normal. </span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">This was because tuberculosis is one of the major causes of anaemia due to chronic infection (Cheesbrough, 2006). Also 94 out of the 100 patients had high erythrocyte sedimentation rate whereas only 6 of them where normal. People with infections such as pulmonary tuberculosis normally have high ESR. This was shown in fig. 4.2. Patients with high leucocytes count were 69 out of 100 patients making 69% of patients with leucocytosis.</span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> This was shown in fig4.3 as out of the 100 sampled, 2(2%) had total leucocytes count below 4.0 * 10^3 / ul, 29 (29%) had normal total leucocytes count and 69 (69%) above 11.0 * 10^3 / ul. </span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> Leucocytosis with low Hb reflects pulmonary tuberculosis (Cheesbrough, 2006). Also patients with high neutrophil count were 68 out of 100 patients making 68% of the patients with neutrophilia. Only a few (20) out of the 100 patients had abnormal values for lymphocyte count whereas 17 of the patients making 85% were below 1.5*10<sup>3</sup>/ul (lymphopaenia) and 3 making 15% with lymphocytosis. A few of the patients (slightly above have of the total population (51)) also had abnormal platelet count with 43 of them making (43%) had thrombocytosis and 8 (8%) having thrombopenia and 49 (49%) were normal. </span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"></span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Fig.4.7 and 4.8 above shows the percentage of the study population (pulmonary TB patients) of various ranges of ages and sex (male and female). From fig. 4.8, 55% of the total population suffering from pulmonary tuberculosis was between the ages of 20 – 29 making up the largest age group suffering from pulmonary tuberculosis. The incidence of TB varies with age. In Africa, TB primarily affects adolescents and young adults (W.H.O, 2006). This was followed by the age group 30 – 39 with 37%. The age groups 10 – 19 and 40 – 49 were the least suffering from pulmonary tuberculosis with 4% of the population each. No samples were taken for ages 0 – 9 and 50 – 59. </span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Comparing the results that were gotten from the research carried out in the District hospital, Cape Coast with that of the study done in Ibadan, Nigeria, it was found out that both had majority of the patients being anaemic, high erythrocyte sedimentation rate occurred in most of the patients. Leukocytosis with neutrophilia also occurred in most patients.</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">5.2. CONCLUSION</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The study of the haematological profile of Pulmonary tuberculosis patients in the Cape Coast Metropolitan Hospital indicates a significant change in their haemoglobin (Hb) (very low Hb indicating anaemia), Erythrocyte Sedimentation Rate (ESR) (high ESR values), total leukocyte count (high leukocytes indicating leukocytosis), neutrophil count (high neutrophil count indicating neutrophilia), lymphocyte count and platelet count. A figure also indicated that the age group with the highest frequency of pulmonary tuberculosis was age group 20 to 29 and the age groups with the least number of pulmonary T.B subjects were age groups 10 to 19 and 40 to 49. </span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The study also pointed out that, males were infected with pulmonary tuberculosis than females. </span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Therefore, from the study, haematological changes occur in patients with pulmonary tuberculosis which are high erythrocyte sedimentation rate (ESR), anaemia, leukocytosis, neutrophilia occurring in most patients and lymphopaenia in some patients. Thrombocytosis occurred in some patients, thrombocytopaenia also occurred in some patient. A few of the patients had leucopaenia and lymphocytosis.</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">5.3. RECOMMENDATION</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Based on this observation and the already stated conclusions, I therefore recommend that physicians treat patients suffering from pulmonary tuberculosis not only of pulmonary tuberculosis but underlining haematological disorders as a result of pulmonary tuberculosis. Further studies should also focus on finding the extent of damage caused by these abnormal changes as a co-infection with pulmonary tuberculosis. This will help establish whether these changes significantly affects the progress of pulmonary tuberculosis or the vice versa in pulmonary tuberculosis patients, or it will help establish the relation between pulmonary tuberculosis and abnormal haematological profile in pulmonary T.B patients.</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><br />
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"EpidemiologyGlobal tuberculosis control: epidemiology, strategy, finances. pp. 6–33</span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">World Health Organization (WHO)</span></b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"> WHO report 2008: Global tuberculosis control Retrieved on 13 April 2009.</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Www</span></b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">.wikipedia.com; </span><span style="color: black; font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">retrieved 18-03-2011; 10:45 am.</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
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</div><div align="center" class="MsoNormal" style="line-height: 200%; text-align: center;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">APPENDICE</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">LABORATORY TEST PROCEDURE FOR E.S.R AND FULL BLOOD COUNT</span></b></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">THE ERYTHROCYTE SEDIMENTATION RATE (ESR) TEST</span></b></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The erythrocyte sedimentation rate (ESR) is a non-specific test. It is raised in a wide range of infectious (including pulmonary tuberculosis), inflammatory, degenerative, and malignant conditions associated with changes in plasma proteins, particularly increases in fibrinogen, immunoglobulin, and C-reactive protein. The ESR is also affected by many other factors including anaemia, pregnancy, haemoglobinopathies, haemoconcentration and treatment with anti-inflammatory drugs. Moderately raised sedimentation rates can sometimes be found in healthy people, particularly those living in tropical countries and a ‘normal’ ESR cannot exclude disease. In many tropical countries, ESR measurements have been discontinued because they add little to diagnosing disease, assessing its progress and monitoring response to treatment. When performed, test results were interpreted in conjunction with clinical findings and the results of other laboratory tests.</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">PRINCIPLE OF TEST</span></b></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">When citrated blood is vertically positioned and Westergren pipette is left undisturbed, red cells aggregate, stack together to form rouleaux, and sediment through the plasma. The ESR is the rate at which this sedimentation occurs in 1 hour as indicated by the length of the column of clear plasma above the red cells, measured in mm. Fibrinogen, immunoglobulin, and C reactive protein increase red cell aggregation. Sedimentation is increased when the ratio of red cells to plasma is altered, e.g. in anaemia. Sedimentation is reduced when the red cells are abnormally shaped, e.g. sickle cells. High temperatures (over 25 degrees Celsius) increase sedimentation.</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
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</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">EQUIPMENT USED FOR THE TEST</span></b></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The following equipments were used for the test: westergren ESR pipette, westergren ESR stand with leveling device and timer capable of timing accurately 1 hour.</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">REAGENT USED</span></b></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Tri</span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">-Sodium citrate, 32 g/l (3.2% W/v) anticoagulant, stored at 4-8 degrees Celsius.</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">TEST METHOD</span></b></div><div class="MsoListParagraphCxSpFirst" style="line-height: 200%; margin: 0in 0in 0.0001pt 0.25in; text-align: justify; text-indent: -0.25in;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">1.<span style="font: 7pt "times new roman";"> </span></span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">0.4 ml of sodium citrate anticoagulant was pipette into a small container for each patient.</span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 200%; margin: 0in 0in 0.0001pt 0.25in; text-align: justify; text-indent: -0.25in;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">2.<span style="font: 7pt "times new roman";"> </span></span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">1.6 ml of the EDTA anticoagulated blood was added and mixed well. The cap of the container was removed and the sample placed in the ESR stand. A Westergren pipette was inserted and ensured it is positioned vertically.</span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 200%; margin: 0in 0in 0.0001pt 0.25in; text-align: justify; text-indent: -0.25in;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">3.<span style="font: 7pt "times new roman";"> </span></span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">Using a safe suction method, blood was drawn to the 0 mark of the Westergren pipette, avoiding air bubbles.</span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 200%; margin: 0in 0in 0.0001pt 0.25in; text-align: justify; text-indent: -0.25in;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">4.<span style="font: 7pt "times new roman";"> </span></span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The ESR stand was checked if it was leveled by making sure that the bubble in the spirit level is central.</span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 200%; margin: 0in 0in 0.0001pt 0.25in; text-align: justify; text-indent: -0.25in;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">5.<span style="font: 7pt "times new roman";"> </span></span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The timer was set for 1 hour. Ensuring that the ESR stand and pipette would not be exposed to direct sunlight. </span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 200%; margin: 0in 0in 0.0001pt 0.25in; text-align: justify; text-indent: -0.25in;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">6.<span style="font: 7pt "times new roman";"> </span></span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">After exactly 1 hour, the level at which the plasma meets the red cells in mm was read and recorded</span><span face="" style="font-size: 10pt; line-height: 200%;">.</span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"></span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 200%; margin: 0in 0in 0.0001pt 0.25in; text-align: justify; text-indent: -0.25in;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">7.<span style="font: 7pt "times new roman";"> </span></span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">After reading the ESR, the blood was returned to its container; the pipette was carefully removed and soaked in sodium hypochlorite 2500 ppm av Cl (0.25%) disinfectant. </span></div><div class="MsoListParagraphCxSpLast" style="line-height: 200%; margin: 0in 0in 0.0001pt 0.25in; text-align: justify; text-indent: -0.25in;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">8.<span style="font: 7pt "times new roman";"> </span></span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The blood was disposed off safely and decontaminated the container before washing it and also the ESR stand</span><span face="" style="font-size: 10pt; line-height: 200%;">.</span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;"></span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">THE TEST FOR FULL BLOOD COUNT</span></b></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The full blood count of the samples was done by using the Sysmex XT- 20000 I full count analyzer. The samples were mixed thoroughly before they were run on the analyzer. The sample then goes through some processes within the analyzer to produce results which come out printed on a sheet of paper.</span></div><div class="MsoNormal" style="line-height: 200%; margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 200%;">The results of each sample are taken out and the necessary parameters needed to run the experiment was identified and recorded in a notebook. </span></div><div class="MsoNormal" style="line-height: 200%; text-align: justify;"><br />
</div></div>Unknownnoreply@blogger.com1tag:blogger.com,1999:blog-3973389828232632821.post-62803591189051811332011-05-07T11:31:00.000-07:002011-05-07T11:31:01.548-07:00diabetes - a project work carried in Ghana<div dir="ltr" style="text-align: left;" trbidi="on"><div align="center" class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: center;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">CHAPTER ONE</span></b></div><div align="center" class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: center;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">INTRODUCTION</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">1.1. BACKGROUND </span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><i style="mso-bidi-font-style: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Diabetes</span></i><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;"> <i style="mso-bidi-font-style: normal;">mellitus</i> (Greek <i style="mso-bidi-font-style: normal;">diabetes</i>, “a compass, and siphon”; Latin <i style="mso-bidi-font-style: normal;">mellitus</i>, “honey”) is a syndrome characterized by presence of chronic hyperglycaemia (raised blood sugar) due to defective insulin secretion, insulin action or both. It is estimated to afflict over 140 million people world wide (Wokoma, 2002). The long term effect of diabetes which include progressive development of the specific complication of retinopathy, nephropathy, neuropathy, neuropathy with microvascular disorders such as atherosclerosis are recognized major cause of mortality in the diabetic population and it is implicated in the circulatory disturbance seen in diabetes (Wokoma, 2002).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Most cases of diabetes mellitus falls into three broad categories: type1, type 2 and gestational diabetes. Type 1 Diabetes mellitus is characterized by loss of the insulin-producing beta cells of the islets of Langerhans in the pancreas leading to insulin deficiency. Majority of the type 1 diabetes is of the immune medicated nature, where beta cell loss is a T-cell mediated autoimmune attack (Rother, 2007) Type 1 diabetes can affects children or adults but was traditionally termed “juvenile diabetes” because it represents a majority of the diabetes causes in children.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Type 2 Diabetes mellitus is characterized by insulin resistance which may combine with relative reduced insulin secretion. Type 2 Diabetes<i style="mso-bidi-font-style: normal;"> </i>is the most common type. Gestational diabetes involves a combination of relatively inadequate insulin secretion and responsiveness. It occurs in about 2 – 5% of all pregnancies and may improve or disappear after delivery (Lawrence <i style="mso-bidi-font-style: normal;">et</i> <i style="mso-bidi-font-style: normal;">al.</i>, 2008).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">The cause of diabetes type 2 is due primarily to lifestyle factors and genetics (Riserus <i style="mso-bidi-font-style: normal;">et</i> <i style="mso-bidi-font-style: normal;">al.</i>, 2009). The classical symptoms of diabetes are polyuria (frequent urination), polydipsia (increased thirsty) and polyphagia (increased hunger) symptoms of what may develop rapidly (weeks or months) in type 1 diabetes while in type 2 diabetes, they usually develop much more slowly and may be subtle or absent (Cooke <i style="mso-bidi-font-style: normal;">et al.</i>, 2008).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">In 2002, the prevalence of <i style="mso-bidi-font-style: normal;">Diabetes mellitus </i>among all age groups worldwide was estimated at 2.8% and projected to be 4.4% by 2030 (Rheeder, 2006). In 2010, the international Diabetes Federation (IDF) reported the prevalence of DM to be 3.6% of 13 million Ghanaians between the ages of 20 – 79 years (</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Kengne <i style="mso-bidi-font-style: normal;">et al</i>., 2005</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Platelets are derived from fragmentation of precursor megakaryocles in the bone marrow. They play a fundamental role in haemostasis and are natural source of growth factors. Platelet disorders or thrombocytopathy may be either thrombocytopenia (decrease in number of platelets), thrombosthemia (decrease in function) or thrombocytosis (increase in number of platelets) (</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 10.0pt; mso-bidi-theme-font: minor-bidi;">Toryila</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;"> <i style="mso-bidi-font-style: normal;">et al.,</i> 2009).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Platelets are heterogeneous with respect to their size, density and reactivity. It is suggested that changes in platelet size are determined at thrombopoiesis in the negakaryocytes and those changes may precede acute cardiac events (</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 10.0pt; mso-bidi-theme-font: minor-bidi;">Toryila</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;"> <i style="mso-bidi-font-style: normal;">et al.,</i> 2009). The large platelets (Giant platelets)<i style="mso-bidi-font-style: normal;"> </i>were thought to be young because it had previously been suggested that platelets decrease in size as the age during their lifetime in the circulation (</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 10.0pt; mso-bidi-theme-font: minor-bidi;">Toryila</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;"> <i style="mso-bidi-font-style: normal;">et al.,</i> 2009).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Platelets form the platelets plug, playing a pivotal role in haemostasis with platelets membrane, glycoproteins mediating binding to subendothetical tissue and aggregation into haemostatic plugs (George, 2000). Reduced platelet will result in a bleeding tendency; while stimulation of platelets can lead to thrombosis (Ruttmann, 2006). In addition, aggregated, activated platelets provide procoagulated phospholipid equivalent surfaces upon which the complex-dependent reactions of the blood coagulation cascade are localized (Ruttmann, 2006).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Normal blood clots are part of the body’s healing process. Platelets which are small blood cells are held together by a glue-like substance that is made when proteins known as clotting factors triggered. The clot seals a cut or break that may be outside or inside the body. Once the damage is healed, natural processes go to work to break up and dissolved the clot. Diabetes patients could die from heart and blood vessel complications, which include clot fragments that have broken free (Ruttmann, 2006).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Cardiovascular disease, particularly coronary artery disease (CAD), often presenting as an acute coronary syndrome (ACS), is the leading cause of morbidity and mortality in patients with Diabetes<i style="mso-bidi-font-style: normal;"> </i>mellitus<i style="mso-bidi-font-style: normal;"> </i>(</span><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 10.0pt; mso-bidi-font-style: italic; mso-bidi-theme-font: minor-bidi;">Ferreiro <i>et al.</i></span><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">, 2010).</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;"> Of note, Diabetes<i style="mso-bidi-font-style: normal;"> </i>mellitus patients without any history of CAD have the same cardiac mortality risk as non-Diabetes<i style="mso-bidi-font-style: normal;"> </i>mellitus patients with a history of myocardial infarction (MI)<i style="mso-bidi-font-style: normal;"> </i>cardiovascular disease has also worse prognosis in patients with Diabetes<i style="mso-bidi-font-style: normal;"> </i>mellitus<i style="mso-bidi-font-style: normal;"> </i>as they have a higher risk of complications and recurrent atherothrombotic event than non-Diabetes<i style="mso-bidi-font-style: normal;"> </i>mellitus<i style="mso-bidi-font-style: normal;"> </i>patients (<span style="color: black;">Lüscher <i style="mso-bidi-font-style: normal;">et al.</i>, 2003)</span>.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">In fact, Diabetes<i style="mso-bidi-font-style: normal;"> </i>mellitus<i style="mso-bidi-font-style: normal;"> </i>is a strong independent predictor of short and long term recurrent ischaemic events, including mortality, in and ACS scenario. (<span style="color: black;">Malmberg <i style="mso-bidi-font-style: normal;">et al</i>., 2000; Roffi <i style="mso-bidi-font-style: normal;">et al</i>., 2001).</span> Further, the concomitant presence of cardiovascular risk factors and comorbidities that negatively impact the outcomes of ACS is higher in Diabetes mellitus patients (<span style="color: black;">Brogan <i style="mso-bidi-font-style: normal;">et al.</i>, 2006).</span></span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Several factors contribute to the prothrombotic conditions that characterized patients with Diabetes<i style="mso-bidi-font-style: normal;"> </i>mellitus, such as increased coagulation, impaired fibrinolysis, endothelial dysfunction and platelet hyperreactivity (<span style="color: black;">Creager <i style="mso-bidi-font-style: normal;">et al</i>, 2003; Osende <i style="mso-bidi-font-style: normal;">et al</i>, 2001).</span> The latter is of particular interest since platelets play a key role in the formation, development and sustainment of thrombi, which are platelet-driven processes (<span style="color: black;">Davì and Patrono, 2007).</span> Platelets of patients with Diabetes mellitus are characterized by dysregulation of several signaling pathways and have been proven to be hyperreactive with intensified adhesion, activation and aggregation (<span style="color: black;">Creager <i style="mso-bidi-font-style: normal;">et al.</i>, 2003; Stratmann and Tschoepe, 2005; Angiolillo <i style="mso-bidi-font-style: normal;">et al.</i>, 2005; Vinik <i style="mso-bidi-font-style: normal;">et al.</i>, 2001; Ferroni <i style="mso-bidi-font-style: normal;">et al.</i>, 2004). </span><span style="mso-spacerun: yes;"> </span>Such a hyperreactive platelet phenotype may contribute to the higher proportion of Diabetes mellitus<i style="mso-bidi-font-style: normal;"> </i>patients with inadequate response to antiplatelet agents compared with non- Diabetes mellitus subjects (<span style="color: black;">Angiolillo, 2009; Natarajan <i style="mso-bidi-font-style: normal;">et al.</i>, 2008).</span></span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Multiple mechanisms caused by metabolic and cellular abnormalities have been suggested to play a role in the increased platelet reactivity observed in patients with Diabetes mellitus. These mechanisms can be grouped together into the following aetiopathogenic categories a) hyperglycaemia, b) insulin deficiency and resistance c) associated metabolic conditions and d) other cellular abnormalities (<span style="color: black;">Ferreiro and Angiolillo, 2010).</span></span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Diabetes<i style="mso-bidi-font-style: normal;"> </i>mellitus is associated with both metabolic and vascular abnormalities and although a causal link between the two has been suggested. This has not been fully established (<span style="color: black;">Brogan <i style="mso-bidi-font-style: normal;">et al.</i>, 2006</span>). Patients with diabetes mellitus have an increased risk of cardiovascular diseases, especially myocardial infarction, cerebrovascular and peripheral vascular diseases. These complications account for 80% of the deaths in people with non-insulin dependent diabetes, with 60% attributable to ischemic heart disease. Thus much attention has been devoted to the pathogenic factors, altered haemostatic balance, including abnormalities in platelet function, increase in blood coagulability and altered fibrinolytic system (Schweigart</span><i><span style="color: red; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 8.0pt; mso-bidi-theme-font: minor-bidi;"> </span></i><i><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 8.0pt; mso-bidi-theme-font: minor-bidi;">et al</span></i><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 8.0pt; mso-bidi-font-style: italic; mso-bidi-theme-font: minor-bidi;">., 2004</span><i><span style="color: red; font-family: "Times New Roman", "serif"; font-size: 8pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">.</span></i><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">). </span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
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</div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">1.2 STATEMENT OF THE PROBLEM</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">The global burden of disease study of the World Health Organization (WHO) estimated that about 177 million people in the world had diabetes in the year 2000 (</span><a href="http://www.ncbi.nlm.nih.gov/books/NBK2291/#A1907"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB; text-decoration: none; text-underline: none;">WHO, 2003</span></a><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">). In the second edition of the International Diabetes Federation's <span style="mso-bidi-font-style: italic;">Diabetes<i> </i>Atlas</span> it is estimated that 194 million people had diabetes in the year 2003, and about two-thirds of these people lived in developing countries (</span><a href="http://www.ncbi.nlm.nih.gov/books/NBK2291/#A1842"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB; text-decoration: none; text-underline: none;">IDF, 2003</span></a><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">). Recent results from the general population of Tanzania, where a morbidity and mortality surveillance system has been set up, show that stroke mortality was three to six times that of England and Wales and that 4.4 percent of type 2 diabetic patients presented with stroke at the diagnosis of diabetes (</span><a href="http://www.ncbi.nlm.nih.gov/books/NBK2291/#A1902"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB; text-decoration: none; text-underline: none;">Whiting <i style="mso-bidi-font-style: normal;">et al.</i>, 2003</span></a><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">). Part of this is attributed to the deep vein thrombosis and myocardial infarction conditions of diabetic patients. Therefore there is the need to research into the estimation of platelet level and clotting time in diabetic patients attending the Central Regional Hospital.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">1.3. JUSTIFICATION</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Adoption of Western lifestyles has been established as a consistent<sup> </sup>theme for the rise in diabetes<sup> </sup>in sub-Saharan Africa (Aspray <i style="mso-bidi-font-style: normal;">et al</i>., 2003). The result of this study would expose the prevalence of </span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">atherosclerosis among diabetic patients in setting and this could largely help in policy formulation in the monitoring and management of diabetes.</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"> Approximately 75% of patients with diabetes<sup> </sup>identified in community surveys in sub-Saharan Africa do not<sup> </sup>know that they have diabetes. They often have complications<sup> </sup>at the time of diagnosis with the estimated duration of type 2 diabetes<sup> </sup>mellitus from onset to diagnosis is 7 years (Nkegoum. 2002). However, targeted screening to identify individuals<sup> </sup>with high-risk characteristics should be undertaken and would be ideal in driving policy to help reduce incidence of diabetes in Ghana and the sub – regions.</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;"></span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">1.4. HYPOTHESIS</span></b><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;"></span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Diabetes patients suffer from thrombocytopathy as a result of increased production level of platelet in their circulatory system and a minimum clotting time as compared with non diabetic patients. Diabetic patients are prone to thrombosis through a complex interplay of hyperlipidemia, platelets, fibrinolysis, thrombosis and endothelial injury. Diabetic patients also have increased level of plasminogen activator inhibitor, von Willebrand factors, factors VIII and VII fibrinogen and thrombin-antithrombin complexes. All these prolong the survival of clots on injured endothelium. Additional factors like decreased level of antithrombin III, protein C and protein S increase the predisposition to thrombosis (Sowers, 2003).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">1.5.1 GENERAL OBJECTIVES</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">The main aim of the study is to determine the quantity of the platelets and the effectiveness of the clotting factors in general in diabetic patients at the Central Regional Hospital.</span></div><div class="MsoListParagraphCxSpFirst" style="line-height: 200%; margin: 12pt 0in 0pt 0.5in; mso-add-space: auto; mso-layout-grid-align: none; mso-list: l3 level3 lfo2; text-align: justify; text-indent: -0.5in;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><span style="mso-list: Ignore;">1.5.2<span style="font: 7pt "Times New Roman";"> </span></span></span></b><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">SPECIFIC OBJECTIVES</span></b></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 200%; margin: 12pt 0in 0pt 0.5in; mso-add-space: auto; mso-layout-grid-align: none; mso-list: l4 level1 lfo1; text-align: justify; text-indent: -0.25in;"><span lang="EN-GB" style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-ansi-language: EN-GB; mso-fareast-font-family: "Times New Roman";"><span style="mso-list: Ignore;">1.<span style="font: 7pt "Times New Roman";"> </span></span></span><span lang="EN-GB" style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-ansi-language: EN-GB;">To estimate the platelets level and clotting time in diabetic patients</span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 200%; margin: 12pt 0in 0pt 0.5in; mso-add-space: auto; mso-layout-grid-align: none; mso-list: l4 level1 lfo1; text-align: justify; text-indent: -0.25in;"><span lang="EN-GB" style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-ansi-language: EN-GB; mso-fareast-font-family: "Times New Roman";"><span style="mso-list: Ignore;">2.<span style="font: 7pt "Times New Roman";"> </span></span></span><span lang="EN-GB" style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-ansi-language: EN-GB;">To estimate the platelets level and clotting time among the various age groups with diabetes.</span></div><div class="MsoListParagraphCxSpLast" style="line-height: 200%; margin: 12pt 0in 0pt 0.5in; mso-add-space: auto; mso-layout-grid-align: none; mso-list: l4 level1 lfo1; text-align: justify; text-indent: -0.25in;"><span lang="EN-GB" style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-ansi-language: EN-GB; mso-fareast-font-family: "Times New Roman";"><span style="mso-list: Ignore;">3.<span style="font: 7pt "Times New Roman";"> </span></span></span><span lang="EN-GB" style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-ansi-language: EN-GB;">To compare the platelet level and clotting time of non diabetic and diabetic patients.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: center;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: center;"><br />
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</div><div align="center" class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: center;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">CHAPTER TWO</span></b></div><div align="center" class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: center;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">LITERATURE REVIEW</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">2.1. Definition Diabetes</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Uncontrolled chronic hyperglycemia results in long-term damage, particular dysfunction, and failure of the eyes, heart, blood vessels, nerves, and kidneys. The global burden of disease study of the World Health Organization (WHO) estimated that about 177 million people in the world had diabetes in the year 2000 (</span><a href="http://www.ncbi.nlm.nih.gov/books/NBK2291/#A1907"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB; text-decoration: none; text-underline: none;">WHO 2003</span></a><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">). In the second edition of the International Diabetes Federation's <i>Diabetes Atlas</i> it is estimated that 194 million people had diabetes in the year 2003, and about two-thirds of these people lived in developing countries (</span><a href="http://www.ncbi.nlm.nih.gov/books/NBK2291/#A1842"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB; text-decoration: none; text-underline: none;">IDF 2003</span></a><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">2.2. History of Diabetes</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Diabetes mellitus describes a metabolic disorder of multiple aetiology characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both (WHO, 2003). Diabetes is an ancient disease. Its symptoms, which include excessive drinking of water and frequent urination (to wash away the excess sugar in the blood), were noted on a scrap of Egyptian papyrus more than 3,500 years ago. The ancient Roman doctor Aretaeus of Cappadocia also gave a vivid description of diabetes,describing it as “a melting down of the flesh and limbs into urine” (Patlak, 2002).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Since then, many physicians have remarked on the sweet taste of diabetic’s urine. The combination of the Greek and Latin word diabetes mellitus means “sweet flow” or “siphon”. Because of this hall mark of diabetes, the disease was thought to be a disorder of the kidneys and bladder for more than two thousand years (Patlak, 2002). In 1776, Matthew Dobson confirms that the sweet taste was because of an excess of a kind of sugar in the urine and blood of people with diabetes (Dobson, 1776).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Diabetes has been recognized since antiquity and treatments of various efficacy have been know in various regions since the middle ages and in legend for much longer, pathogenesis of diabetes has only been understood experimentally since about 1990 (Patlak, 2002). The discovery of a role for the pancreas in diabetes is generally ascribed to Joseph von Mering and Oskar Minkowski in 1889 found that dogs whose pancreas was removed developed all the signs and symptoms of diabetes and died shortly afterwards (Patlak, 2002). In 1910, Sir Edward Albert Sharpey-Schafer suggested that people with diabetes were deficient in a single chemical that was normally produced by the pancreas he proposed calling this substance <i style="mso-bidi-font-style: normal;">insulin</i> from the Latin i<i style="mso-bidi-font-style: normal;">nsula </i>meaning island, in reference to the insulin-producing islets of Langerhans in the pancreas.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">The remarkable success at using insulin to treat diabetes led to the notion that the disease was caused by a lack of insulin. But a series of observations in the 1930s by the British clinician Harry Himsworth lead to a startling new view of diabetes. Curious about how diet affects sensitivity to insulin, Himsworth conducted a series of experiments in both animals and people that led him to the discovery that the body’s used of sugar depends not only on how much insulin is present, but on how sensitive the body is to the effects of insulin. Diabetes could be caused not only by a lack of insulin but also by a lack of sensitivity to insulin (Patlak, 2002).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">The distinction between what is now known as type 1 diabetes and type 2 diabetes was clearly made by Sir Harold Percival (Harry) Himsworth and published in January 1936 (Himsworth, 1936). Himsworth tested out this theory by giving diabetic patients sugar and insulin simultaneously and then checked to see how well the insulin fostered their use of the sugar. If they were relatively insensitive to the effects of insulin, their blood sugar levels shot up. These experiments showed that there were two types of diabetes: type 1 and type 2. People with type 1 diabetes were sensitive to insulin and had a history of suddenly developing the disease at a young age; those with type 2 diabetes were relatively insensitive to insulin and tended to gradually develop a milder form of the disease at middle age of older (Patlak, 2002)</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">In 1960, Yalow and Berson used their new techniques to measure and compare the insulin response to sugar in those with type 2 diabetes to those without the disease. They discovered that instead of producing less insulin after being given sugar, people with type 2 diabetes <span style="mso-spacerun: yes;"> </span>often generated more insulin than did those without diabetes. This perplexing finding was totally unexpected and jotted the diabetes research community.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Other researchers then discovered that although people in the early stages of type 2 diabetes produce more than the normal amounts of insulin, over time, their insulin levels fall until eventually they dip below that seen in normal individuals and their diabetes become severe (Patlak, 2002)</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">The net result of all these findings was the hypothesis that to compensate for their lack of sensitivity to insulin (insulin resistance), people with type 2 diabetes initially produces excess insulin. That excess allows them to sufficiently convert the sugar in their diet to energy their tissues can use. But eventually the insulin-producing cells in the pancreas deteriorate and can’t keep up with the need for insulin. At this point, these people’s diabetes becomes severe, requiring insulin treatment (Patlak, 2002).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">In 2000, according to the World Health Organisation, at least 171 million people world wide suffer from diabetes, of 2.8% of the population (Wild <i style="mso-bidi-font-style: normal;">et al</i>, 2004). Its incidence is increasing rapidly and it is estimated that by 2030, this number will almost double (Wild <i style="mso-bidi-font-style: normal;">et al</i>, 2004). The greatest increase in prevalence is, however; expected to occur in Asia and Africa, where most patients will probably be found by 2030 (Wild <i style="mso-bidi-font-style: normal;">et al.</i>, 2004). The increase incidence of diabetes in developing countries follows the trend of urbanization and lifestyle changes, perhaps most importantly a “Western-style” diet. This suggested an environmental (i.e. dietary) effect, but there is little understanding of the mechanism(s) at present, though there is much speculation some of it most compellingly presented (Wild <i style="mso-bidi-font-style: normal;">et al.</i>, 2004).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; mso-margin-bottom-alt: auto; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">2.3. Classification of Diabetes</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Diabetes mellitus can be classified into four principal types (WHO, 2003). This includes type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes mellitus. The most common types of diabetes seen in Sub-Saharan Africa are type 2 and type 1 diabetes mellitus.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Type 1 diabetes results from autoimmune destruction of the pancreatic beta cells, causing the loss of insulin production. Children are usually affected by this type of diabetes, although it occurs at all ages and the clinical presentation can vary with age. Patients with this type of diabetes require insulin for survival (Mbanya and Ramiaya, 2006).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Type 2 diabetes is characterized by insulin resistance and abnormal insulin secretion, either of which may predominate but both of which are usually present. The specific reasons for the development of these abnormalities are largely unknown. Type 2 is the most common type of diabetes. Type 2 diabetes can remain asymptomatic for many years, and the diagnosis is often made from associated complications or incidentally through an abnormal blood or urine glucose test (Mbanya and Ramiaya, 2006).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Other specific types of diabetes include those due to genetic disorders, infections, diseases of the exocrine pancreas, endocrinopathies, and drugs. This last type of diabetes is relatively uncommon (Mbanya and Ramiaya, 2006).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. The definition applies whether insulin or only diet modification is used for treatment and whether the condition persists after pregnancy. It does not exclude the possibility that unrecognized glucose intolerance may have antedated or begun concomitantly with the pregnancy. Approximately 7 percent of all pregnancies are complicated by GDM. The prevalence may range from 1 to 14 percent of all pregnancies, depending on the population studied and the diagnostic tests employed (Mbanya and Ramiaya, 2006).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">The prevalence diabetes in blacks follows a Westernization gradient, with that of rural Africa generally below 1 percent but that of urban Africa between 1 and 6 percent. In general the prevalence of type 2 diabetes is low in both rural and urban communities of West Africa except in urban Ghana, where a high rate of 6.3 percent was recently reported (</span><a href="http://www.ncbi.nlm.nih.gov/books/NBK2291/#A1813"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB; text-decoration: none; text-underline: none;">Amoah <i style="mso-bidi-font-style: normal;">et al</i>., 2002</span></a><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">). <span style="mso-spacerun: yes;"> </span>The prevalence of undiagnosed diabetes, which accounted for 60 percent of those with diabetes in Cameroon (</span><a href="http://www.ncbi.nlm.nih.gov/books/NBK2291/#A1857"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB; text-decoration: none; text-underline: none;">Mbanya <i style="mso-bidi-font-style: normal;">et al</i>., 2001</span></a><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">), 70 percent in Ghana (</span><a href="http://www.ncbi.nlm.nih.gov/books/NBK2291/#A1813"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB; text-decoration: none; text-underline: none;">Amoah<i style="mso-bidi-font-style: normal;"> et al</i>., 2002</span></a><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">), and over 80 percent in the recent study in Tanzania (</span><a href="http://www.ncbi.nlm.nih.gov/books/NBK2291/#A1816"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB; text-decoration: none; text-underline: none;">Aspray <i style="mso-bidi-font-style: normal;">et al</i>., 2000</span></a><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">). It would therefore appear that in Sub-Saharan Africa, for every diagnosed person with diabetes, there are one to three undiagnosed cases.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">2.4.1. Haemostasis </span></b><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;"></span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Normal haemostasis is the ability of the haemostatic system to control activation of clot formation and clot lysis in order to prevent haemorrhage without causing thrombosis. It classically involves vasoconstriction, platelet adhesion and aggregation at the site of injury, leading to a plug formation. This is followed by fibrin formation consolidating the plug and rendering it stable (Ruttmann, 2006).</span><span style="font-family: "Times New Roman", "serif"; font-size: 13pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 12.0pt; mso-bidi-theme-font: minor-bidi;"> </span><span style="color: #231f20; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 11.0pt; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Berkeley-Book;">Coagulation is divided into two major systems: the primary and secondary systems of hemostasis. The </span><span style="color: #231f20; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Berkeley-Book;">primary system comprises platelet function and <span style="mso-bidi-font-weight: bold;">vasoconstriction.<b> </b></span>The secondary system involves coagulation<b> </b>proteins and a series of enzymatic reactions (Davis and Patrono, 2007).</span><span style="color: #231f20; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 11.0pt; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Berkeley-Book;"></span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">2.4.2. Platelet production</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Platelets are small (2 μm diameter), non-nucleated blood cells, which are activated rapidly after blood vessel injury or blood exposure to artificial surfaces, providing haemostasis by four interconnected mechanisms: (<i>i</i>) adhering to sites of vascular injury or artificial surfaces; (<i>ii</i>) releasing compounds from their granules; (<i>iii</i>) aggregating together to form a haemostatic platelet plug; and (<i>iv</i>) providing a procoagulant surface for activated coagulation protein complexes on their phospholipid membranes (</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman";">O’Connell <i style="mso-bidi-font-style: normal;">et al</i></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">., 2008).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Reduced platelet activity will result in a bleeding tendency, while stimulation of platelets can lead to thrombosis (Ruttmann, 2006). Platelets are extremely small and discoid, 3.0 X 0.5µm in diameter, with a mean volume 7 – 11 fL. The platelets have glycoproteins on the surface coat which are important in their reaction of adhesion and aggregation which are the initial events leading to platelet plug formation during haemostasis. Adhesion to collagen is facilitated by glycoprotein Ia (GPIa). Glycoproteins Ib and IIb/ IIIa are important in the attachments of platelets to von Willebrand factor (vWF) and hence to vascular subendothelium where metabolic interactions occur (</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 10.0pt; mso-bidi-theme-font: minor-bidi;">Collins </span><i style="mso-bidi-font-style: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">et al</span></i><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">, 2007). </span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Platelet aggregation itself also involves positive feed backs through the release from platelets of platelet agonists such as adenosine diphosphate (ADP) and thromboxane A2 (Ruttmann, 2006).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Nitric oxide (NO) is constitutively released from endothelial cells and also from macrophages and platelets. It has a short half-life of 3 – 5 seconds. It inhibits platelet activation and promotes vasodilatation. Prostacyclin synthesized by endothelial cells also inhibits platelet function and causes vasodilatation by raising cyclic guanosine monophospate (GMP) levels. The transmembrane protein PECAM-1 is expressed also on endothelial cells. It is its own ligand and inhibits platelet activation by collage (Ruttmann, 2006).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><b><span style="color: #231f20; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Berkeley-Book;">2.4.3. Coagulation cascade</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="color: #231f20; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 11.0pt; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Berkeley-Book;">Coagulation factors are produced in the liver, except for factor VIII, which is believed to be produced in the endothelial cells. The initiation of clotting begins with the activation of two enzymatic pathways that will ultimately lead to fibrin formation: the intrinsic and extrinsic pathways </span><span style="color: #231f20; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Berkeley-Book;">(Davi and Patrono, 2007).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">The ‘extrinsic pathway’ is the primary route of thrombin formation, through which the physiological haemostatic response occurs. It occurs through contact with a non-blood protein source. The physiological initiator of coagulation is <span style="mso-bidi-font-style: italic;">tissue factor</span>, which comes into contact with the blood at the site of vascular injury and combines with plasma serine protease, factor VII (Ruttmann, 2006). The tissue factor/factor VIIa (TF/VIIa) complex activates factor X to factor Xa. It can, however, also activate factor IX to IXa (Ruttmann, 2006). </span><span style="font-family: "Times New Roman", "serif"; font-size: 13pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 12.0pt; mso-bidi-theme-font: minor-bidi;"><span style="mso-spacerun: yes;"> </span></span><span style="color: #231f20; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 11.0pt; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Berkeley-Book;">Factor VII forms a complex with tissue thromboplastin and calcium. This complex converts factors X and Xa, which in turn converts prothrombin to thrombin. Thrombin then converts fibrinogen to fibrin. This process takes between 10 and 15 seconds </span><span style="color: #231f20; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Berkeley-Book;">(Davis and Patrono, 2007).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="color: #231f20; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 11.0pt; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Berkeley-Book;">The </span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">‘intrinsic pathway’ starts with the formation of factor XIIa This can cleave prekallikrein to provide kallikrein, which in turn reciprocally activates factor XII. Factor XIIa, in the presence of highmolecular- weight kininogen, converts factor XI to factor XIa, which in turn converts factor IX to factor IXa. Factor IXa binds with its cofactor protein factor VIIIa, in the presence of calcium and the appropriate membrane surface, and activates factor X to factor Xa (Ruttmann, 2006). </span><span style="color: #231f20; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 11.0pt; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Berkeley-Book;">The reaction then enters the common pathway where both systems involve factors I, II, V, and X. This results in a fibrin monomer polymerizing into a fibrin clot. Factor XIII, or fibrin stabilizing factor, follows activation by thrombin. This will convert initial weak hydrogen bonds, cross-linking fibrin polymers to a more stable covalent bond </span><span style="color: #231f20; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Berkeley-Book;">(Davis and Patrono, 2007).</span><span style="color: #231f20; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 11.0pt; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Berkeley-Book;"></span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 25.0pt; mso-bidi-theme-font: minor-bidi;">2.5. Disturbances of haemostasis in Diabetes mellitus</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="color: #141314; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">There is increasing evidence that diabetes mellitus is associated with several defects of coagulation and fibrinolysis that lead to a procoagulant, thrombogenic predisposition. Raised concentrations of fibrinogen, von Willebrand factor and other endothelium-derived mediators increase blood viscosity and promote platelet activation and adhesion. In addition, fibrinolysis is impaired by raised concentrations of plasminogen activator inhibitor-1 (Petrauskiene <i style="mso-bidi-font-style: normal;">et al</i>., 2005). </span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 10.0pt; mso-bidi-theme-font: minor-bidi;">The fibrinolytic system is natural defense against thrombosis. A balance exists between plasminogen activators and inhibitors, and impairment of this balance can caused either by diminished release of tissue plasminogen activator (t-PA) or increased levels of plasminogen activator inhibitor 1 (PAI-1). PAI-1 is a serine protease inhibitor and evidence suggests that</span><span style="font-family: "Times New Roman", "serif"; font-size: 14pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 10.0pt; mso-bidi-theme-font: minor-bidi;"> </span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 10.0pt; mso-bidi-theme-font: minor-bidi;">it is the major regulator of the fibrinolytic system. It binds and rapidly inhibits from an inactive irreversible complex (</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 8.0pt; mso-bidi-theme-font: minor-bidi;">Carr, 2001).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Diabetic patients are considered to be at increased risk of thromboembolic disease.<span style="mso-spacerun: yes;"> </span>These patients are particularly prone to the classic presentations of thrombophilic diathesis, such as deep vein thrombosis or pulmonary embolism, but are at high risk for atherosclerosis and its vaso-occlusive complications (Wokoma, 2002). Fibrinolytic activity has been reported to be normal, elevated or low in diabetic patients. Alterations in factors such as fibrinogen concentration and turnover, fibronectin, and platelet adhesiveness and aggregation are found in non-insulin dependent diabetic patients and can lead to excess accumulation of fibrin and platelet on vascular walls (Schweigart</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 8.0pt; mso-bidi-font-style: italic; mso-bidi-theme-font: minor-bidi; mso-fareast-language: EN-GB;"> <i>et al</i>., 2005)</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Regarding fibrinogen level, high significant level is demonstrated in diabetes. Increase plasma fibrinogen may contribute to a hypercoagulable state in non-insulin dependent diabetes mellitus. Fibrinogen may induce thrombus formation by affecting platelets and erythrocytes to aggregation and by promoting increased blood viscosity. Plasma fibrinogen is often elevated in diabetes which has been identified as a major vascular risk factor (Schweigart</span><i><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 8.0pt; mso-bidi-theme-font: minor-bidi; mso-fareast-language: EN-GB;"> et al</span></i><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 8.0pt; mso-bidi-font-style: italic; mso-bidi-theme-font: minor-bidi; mso-fareast-language: EN-GB;">., 2004)</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">In diabetic state, there is increased platelet derived nitric oxide destruction, contributing to increased platelet aggregation and adhesion to endothelial cells (</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 10.0pt; mso-bidi-theme-font: minor-bidi;">Shammas</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">, 2007). Other platelet abnormalities in diabetic include decreased platelet survival, increased platelet generation of vasoconstrictor prostanoids, reduced platelet generation of prostacyclin and increased glycosylation of platelet proteins. The major clinical manifestations are thrombosis and hemorrhage, probably reflecting both qualitative and quantitative abnormalities in platelets (</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 10.0pt; mso-bidi-theme-font: minor-bidi;">Shammas</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">, 2007).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">2.6. Information and knowledge associated with diabetes</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Decision makers need to be fully informed with clear and up-to-date<sup> </sup>evidence about the burden and the impact of diabetes mellitus<sup> </sup>and its complications. In addition, the advocacy base for diabetes<sup> </sup>awareness needs to be expanded. Furthermore, gaps in our knowledge<sup> </sup>about diabetes control in sub-Saharan Africa should be addressed<sup> </sup>using a "grand challenges initiative" (Varmus <i style="mso-bidi-font-style: normal;">et al</i>., 2003).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; mso-margin-bottom-alt: auto; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">The role of government is critical to the development and implementation<sup> </sup>of well-grounded risk-factor control programs such as the WHO’s<sup> </sup>Framework Convention on Tobacco Control, which also has implications<sup> </sup>for food policies (Yach <i style="mso-bidi-font-style: normal;">et al</i>., 2003).<span style="mso-spacerun: yes;"> </span>Approximately 75% of patients with diabetes<sup> </sup>identified in community surveys in sub-Saharan Africa do not<sup> </sup>know that they have diabetes. They often have complications<sup> </sup>at the time of diagnosis; the estimated duration of type 2 diabetes<sup> </sup>mellitus from onset to diagnosis is 7 years (Krauss and Siri, 2004). Widespread screening<sup> </sup>in the general population cannot be encouraged in sub-Saharan<sup> </sup>Africa. However, targeted screening to identify individuals<sup> </sup>with high-risk characteristics should be undertaken.<sup> </sup></span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Health systems should be realigned to accommodate the diagnosis<sup> </sup>and primary and secondary prevention of diabetes and its complications<sup> </sup>in sub-Saharan Africa. Governments need to support this transformation<sup> </sup>if they are to realize significant health gains. The potential<sup> </sup>for secondary prevention of cardiovascular disease and diabetes<sup> </sup>in developing countries has recently been highlighted (WHO, 2002; Beaglehole and Yach, 2003), but policy needs to be translated into action.</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;"></span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="color: #231f20; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 11.0pt; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Berkeley-Book;">In summary, </span><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 10.0pt; mso-bidi-theme-font: minor-bidi;">Patients with diabetes mellitus (DM) have accelerated atherosclerosis, which is the main underlying factor contributing to the high risk of atherothrombotic events in these patients. Atherothrombotic complications are the leading cause of morbidity and mortality in patients with DM. Among factors contributing to the prothrombotic condition which characterise patients with DM, platelet hyperreactivity plays a pivotal role. Platelets of DM patients are characterised by dysregulation of several signalling pathways leading to intensified adhesion, activation and aggregation. Multiple mechanisms are involved in platelet dysfunction of patients with DM, which can be categorised as follows: a) hyperglycaemia, b) insulin deficiency and resistance, c) associated metabolic conditions, and d) other cellular abnormalities.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 10.0pt; mso-bidi-theme-font: minor-bidi;">Diabetic patients are therefore prone to thrombosis through a complex interplay of hyperlipidemia, platelets, fibrinolysis and endothelial injury.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><br />
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</div><div align="center" class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: center;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">CHAPTER THREE</span></b></div><div align="center" class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: center;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">METHODOLOGY</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">3.1.0 STUDY AREA</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">The study was in Cape Coast in central region of Ghana, which was historically part of western region until 1970 when it was carved out just before the 1970 population census. It occupies an area of about 9,826 square kilometres or 4.1 percent of Ghana’s land area. The research was targeted at diabetic patients, who visited the Central Regional Hospital’s Diabetic Clinic for medical review.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">3.1.1 STUDY PERIOD</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">The study was conducted between the months of December, 2010 and February, 2011.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">3.2.0 ETHICAL CLEARANCE</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">With the assistance of Head of the Diabetic Clinic in the Central Regional Hospital, informed consents were obtained from the administration of the hospital and the patients after reading and listening to the verbal description of the study’s objectives with the assurance that all information obtained would be treated with utmost confidentiality and used for the purpose of the research only.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">3.3.0 SAMPLING AND DATA COLLECTION</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">A sample size of two hundred and seventy seven was used for the study and sampling includes volunteer diabetic patients who visited the Diabetic Clinic at the Central Regional Hospital.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">3.3.1 SAMPLING</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">The whole blood clotting time was determined using the Lee – White method (Lewis <i style="mso-bidi-font-style: normal;">et al</i>, 2006). The haematological analysis from the Abbott Cell – Dyne product line (CELL DYNE 1800) was used to determine the platelet counts based on manufactures protocol and laboratory procedure.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">3.4.0 LIMITATIONS</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">a. Only patients who have already been diagnosed were sampled.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">b. The unwillingness of some patients to be added to the sample size.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">3.5.0 DELIMITATION</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">The study covered patients with type 2 Diabetes mellitus irrespective of the age and the sex. Both the platelet counts and the clotting time were carried out for the patients whose samples were collected.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">3.6.0 DATA ANALYSIS</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; tab-stops: 55.5pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Data from the samples taken were present in tables and graphs using Microsoft Excel and SPSS was use to test for the ANOVA.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><br />
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</div><div align="center" class="MsoNormal" style="margin: 0in 0in 10pt; text-align: center;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; mso-bidi-font-size: 11.0pt;">CHAPTER FOUR</span></b></div><div align="center" class="MsoNormal" style="margin: 0in 0in 10pt; text-align: center;"><br />
</div><div align="center" class="MsoNormal" style="margin: 0in 0in 10pt; text-align: center;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; mso-bidi-font-size: 11.0pt;">RESULTS</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 11.0pt;">A total of 209 diabetic patients and 68 non – diabetic patients were sampled for platelet count and clotting time.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 11.0pt;">4.1 Distribution of sexes among the sampled population</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 11.0pt;">Out of the 277 sampled, 51 (24.4%) and 158 (75.6%) were diabetic males and females respectively and 26 (38.2%) and 42 (61.8%) were non – diabetic males and females. <b style="mso-bidi-font-weight: normal;"></b></span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 11.0pt; mso-no-proof: yes;"><shapetype coordsize="21600,21600" filled="f" id="_x0000_t75" o:preferrelative="t" o:spt="75" path="m@4@5l@4@11@9@11@9@5xe" stroked="f"><stroke joinstyle="miter"></stroke><formulas><f eqn="if lineDrawn pixelLineWidth 0"></f><f eqn="sum @0 1 0"></f><f eqn="sum 0 0 @1"></f><f eqn="prod @2 1 2"></f><f eqn="prod @3 21600 pixelWidth"></f><f eqn="prod @3 21600 pixelHeight"></f><f eqn="sum @0 0 1"></f><f eqn="prod @6 1 2"></f><f eqn="prod @7 21600 pixelWidth"></f><f eqn="sum @8 21600 0"></f><f eqn="prod @7 21600 pixelHeight"></f><f eqn="sum @10 21600 0"></f></formulas><path gradientshapeok="t" o:connecttype="rect" o:extrusionok="f"></path><lock aspectratio="t" v:ext="edit"></lock></shapetype><shape id="Chart_x0020_26" o:gfxdata="UEsDBBQABgAIAAAAIQDVHvRgEwEAAKECAAATAAAAW0NvbnRlbnRfVHlwZXNdLnhtbKySu07EMBBF
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</div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 11.0pt;">4.2 Age distribution among the sampled population</span></b><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 11.0pt;"></span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 11.0pt;">Majority 70 (33.5%) of the diabetics were aged between 56–65yrs, followed by 46–55yrs 62 (29.7%), and with a least of 8 (3.8%) aged above 75yrs, whilst the majority of non–diabetic patients were aged below 35yrs, 41 (60.29%), and least of 2 (2.94%) aged 46–55yrs and 66–75yrs.</span></div><div class="MsoNormal" style="line-height: 150%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 150%; mso-bidi-font-size: 11.0pt; mso-no-proof: yes;"><shape id="Chart_x0020_28" o:gfxdata="UEsDBBQABgAIAAAAIQDVHvRgEwEAAKECAAATAAAAW0NvbnRlbnRfVHlwZXNdLnhtbKySu07EMBBF
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" o:spid="_x0000_s1026" style="height: 261.1pt; left: 0px; margin-left: 0px; margin-top: 0px; mso-position-horizontal-relative: text; mso-position-horizontal: left; mso-position-vertical-relative: text; mso-position-vertical: top; mso-wrap-distance-bottom: 10.83pt; mso-wrap-distance-left: 23.4pt; mso-wrap-distance-right: 48.3pt; mso-wrap-distance-top: 16.8pt; position: absolute; text-align: left; visibility: visible; width: 400.8pt; z-index: 2;" type="#_x0000_t75"><imagedata o:title="" src="file:///C:\Users\delaTONY\AppData\Local\Temp\msohtmlclip1\01\clip_image019.png"></imagedata><lock aspectratio="f" v:ext="edit"></lock><wrap type="square"></wrap></shape><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 11.0pt;"></span></div><div align="center" class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: center;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: center;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 11.0pt;"><br clear="all" style="mso-special-character: line-break;" /></span></div><div align="center" class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: center;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: center;"><br />
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</div><div align="center" class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: center;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 11.0pt;">CHAPTER FIVE</span></b></div><div align="center" class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: center;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 11.0pt;">DISCUSSION, CONCLUSION AND RECOMMENDATION</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 11.0pt;">5.1 DISCUSSION</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Type<sup> </sup>2 diabetes and its associated long-term complications continue<sup> </sup>to accelerate among patients who reside in developing countries. With the modernization of cultures taking place all over the<sup> </sup>world, the standard of living and lifestyle in many sub-Saharan<sup> </sup>African countries, particularly in urban areas, resembles those<sup> </sup>of many Western countries, with related epidemiological changes (Amoah, 2003). Chronic<sup> </sup>health problems such as cardiovascular diseases and diabetes<sup> </sup>have therefore become at least as important as infectious diseases.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 10.0pt;">Most circulatory disturbances seen in diabetes are compounded by alteration in platelet count and activity, coagulopathy, fibrinolytic aberration and changes in endothelial metabolism (Omar and Ayesha, 2002).</span><span style="font-family: "Times New Roman", "serif"; font-size: 14pt; line-height: 200%; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"> </span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Thrombosis can result from a wide range of conditions with several of them being diabetic condition. However, majority of the diabetics with signs of thrombosis appear to be healthy but were accidentally detected by routine blood testing.</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 10.0pt;"></span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Of the 209 diabetic patients in this study, 6.2% had a fast coagulation time, 93.8% had normal coagulation time. Meanwhile most of the diabetics had normal platelet count (83.3%) with a few showing abnormal high platelet (1.9%) and low platelet (14.8%) count. Comparing hypercoagulation between the diabetics and non–diabetics, 16.2% of the diabetics had abnormal coagulation time compared with none (0%) in non-diabetics. The result of the diabetics can be attributed to the fact with </span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 10.0pt;">increased activation of platelets and </span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">plasma </span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 10.0pt;">fibrinogen; they are prone to cardiovascular disease such as obesity and hypercholesterolemia</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"> (</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 10.0pt;">Muscari <i>et al.</i>, 2008).</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"> This also confirms the work of Kengne <i style="mso-bidi-font-style: normal;">et al</i>., (2005) carried out in sub-Saharan Africa stating that 4%-28% of type 2 diabetes have coagulopathy as a result of reduced coagulation time which put the diabetics at risk of myocardial infarction. Studies done by </span><a href="http://www.ncbi.nlm.nih.gov/books/NBK2291/#A1902"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB; text-decoration: none; text-underline: none;">Walker <i style="mso-bidi-font-style: normal;">et al</i>., (2000</span></a><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">) indicated that 4.4 percent of type 2 diabetic patients in Tanzania presented fast coagulation time and stroke at the diagnosis of diabetes.</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 10.0pt;"></span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="color: #231f20; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">More females (75.6%) attended the diabetic clinic than the males (24.4%) and yet more females (4.30%) show fastness in their coagulation time. This could be due to the various physiological changes which occur in females as a result of pregnancy, delivery and the use of oral contraceptives which affect the production of antithrombin III (natural anticoagulant) in regulating coagulation. Normal flow of blood prevents the accumulation of procoagulant material. This mechanism is enhancing when the diabetics engage in physical activities. Research conducted by </span><a href="http://www.ncbi.nlm.nih.gov/books/NBK2291/#A1831"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB; text-decoration: none; text-underline: none;">Edwards <i style="mso-bidi-font-style: normal;">et al</i>., (2000</span></a><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">) reveals that low physical activity was normal for 22 percent of men and 52 percent of women with diabetes in urban Tanzania, whereas it was usual for only 10 percent of men and 15 percent of women with diabetes living in rural areas. This also gives another reason confirming why the females have fast coagulation time.</span><span style="color: #231f20; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;"></span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Findings of this study indicates that there was significant difference in platelet count and clotting time between the diabetic patients and non diabetic patients (p=0.000). This is in line with the </span><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">study of </span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 8.0pt; mso-bidi-font-style: italic;">Fattah</span><span style="font-family: "Times New Roman", "serif"; font-size: 14pt; line-height: 200%; mso-bidi-font-size: 8.0pt; mso-bidi-font-style: italic;"> </span><i><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 8.0pt;">et al</span></i><i><span style="font-family: "Times New Roman", "serif"; font-size: 10pt; line-height: 200%; mso-bidi-font-size: 8.0pt;">.</span></i><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">, (2004) stating that platelets from DM patients </span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 9.0pt;">have high levels of fibrinogen, </span><i><span style="font-family: "CMMI9", "sans-serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: CMMI9; mso-bidi-font-size: 9.0pt;">a</span></i><span style="font-family: "CMR6", "sans-serif"; font-size: 9pt; line-height: 200%; mso-bidi-font-family: CMR6; mso-bidi-font-size: 6.0pt;">2</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 9.0pt;">- antiplasmin, & PAI and lower level of protein C</span><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">. Since the platelets are slightly reduced below the normal average platelet count, there is increased platelet reactivity caused by hyperglycemia as a result of osmotic effect of glucose that activates platelet GP IIb/IIIa and P-selectin expression. </span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">This indicates that diabetic can develop cardiovascular disease as a result of this coagulopathy. </span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="color: #231f20; font-family: "AdvP92DE", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: AdvP92DE; mso-bidi-font-size: 8.0pt;">Majority of the diabetics fall between the ages of 56 – 65 years (33.5%) and 46 – 55 years (29.7%). Their clotting time and platelet count indicates that there was no significant difference among the various age groups that were affected with the diabetes (p=0.450). This result is in agreement with </span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 10.0pt;">the studies of </span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 8.0pt; mso-bidi-font-style: italic;">Fattah </span><i style="mso-bidi-font-style: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 10.0pt;">et al</span></i><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 10.0pt;">., (2004) who also suggested that any differences in the generation of thrombin activity in plasma of diabetic patients are likely to be insignificant and the blood coagulation is not enhanced in any diabetic patients. This is due to the normal production of</span><span style="font-family: "Times New Roman", "serif"; font-size: 14pt; line-height: 200%; mso-bidi-font-size: 10.0pt;"> </span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 10.0pt;">coagulation factors II, VII and X in diabetic patient. </span><span style="font-family: "Times New Roman", "serif"; font-size: 14pt; line-height: 200%; mso-bidi-font-size: 10.0pt;"><span style="mso-spacerun: yes;"> </span></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 10.0pt;"></span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 10.0pt;">Findings of this study reveals that most of the diabetics had hyperglycemia (60.3%) with the rest been normal (37.3%) and very few in hypoglycemic state (2.4%). </span><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">It is worth mentioning that hyperglycaemia reduce the coagulation time in diabetic patients. Hyperglycaemia activates coagulation by raising concentrations of procoagulant factors (e.g. tissue factor, von Willebrand factor)<span class="A7"><span style="line-height: 200%; mso-ansi-font-size: 12.0pt; mso-bidi-font-size: 12.0pt;"> </span></span>and inhibits fibrinolysis by increasing concentrations of plasminogen activator inhibitor (Boden and Rao, 2007). This is in agreement with the work done by in Sudan which shows that </span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">26%</span><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;"> of </span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">diabetes/hyperglycemia patients were at risk with <span style="mso-bidi-font-weight: bold;">Coronary Artery Diseases (CAD) since they turn out to have least coagulation time (</span>Kingue<span style="mso-bidi-font-weight: bold;"> <i style="mso-bidi-font-style: normal;">et al</i>., 2000).</span></span><span class="A7"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;"></span></span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 10.0pt;">It was observed that all the diabetics under study did not have any significant difference in their clotting time or platelet count irrespective of the age, sex or the state of the glycemia (P=0.490). </span><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">Platelet counts from patients with type-2 Diabetes mellitus were within the normal range (150-400 X10<sup>9</sup>/L). This may indicate that the bone marrow is functioning as expected due to the regular fragmentation of the cytoplasm of megakaryocytes. Also, the normal productions of platelets show that the thrombopoietin produced by the liver and kidneys in regulating the platelet production is not affected by the complication in diabetes. </span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 10.0pt;">High levels of plasma fibrinogen, </span><i><span style="font-family: "CMMI10", "sans-serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: CMMI10; mso-bidi-font-size: 10.0pt;">a</span></i><span style="font-family: "CMR7", "sans-serif"; font-size: 9pt; line-height: 200%; mso-bidi-font-family: CMR7; mso-bidi-font-size: 7.0pt;">2</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 10.0pt;">- antiplasmin, plasminogen activator inhibitor with low plasma protein C activity in diabetics induces thrombus formation by affecting platelets and erythrocytes to aggregate and promote blood viscosity (</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 8.0pt; mso-bidi-font-style: italic;">Fattah <i>et al</i>., 2004)</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 10.0pt;">. From these observations it may be suggested that hypercoagulation can be considered as an additional risk factor for development of thrombosis in diabetic patients</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 8.0pt; mso-bidi-font-style: italic;">.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 8.0pt; mso-bidi-font-style: italic;">5.2 CONCLUSION</span></b><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 10.0pt;"></span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 10.0pt;">Patients with Diabetes mellitus (DM) have </span><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">platelet count within the normal range needed in the normal haemostic response to vascular damage. There was significance difference between the diabetics and the non-diabetics. The non-diabetics have shown an elevated platelet counts more than the diabetics who happen to show normal platelet count and slight thrombopenia.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 10.0pt;">The coagulation time measures the intrinsic system of coagulation. The diabetics happen to have a reduced clotting time compared with the non-diabetics. This reveals that there is elevation of</span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 10.0pt;"> plasma fibrinogen that may contribute to the hypercoagulable state of diabetes mellitus but there was no significant difference between the age groups and the gender of type 2 diabetes.<b style="mso-bidi-font-weight: normal;"><span style="color: black;"></span></b></span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 10.0pt;">5.3 RECOMMENDATION </span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="color: #231f20; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 8.0pt;">Diabetics are prone to thrombosis due to the fact that they do not partake in early diagnosis and monitoring of the glucose level in their blood stream. I therefore recommend the education on the importance on regular checking of the glucose level in the blood and the function of the pancreas and insulin level that is been produced. The patients should be taught the essence of engaging in active physical activity so that the blood will always have a normal flow. </span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="color: #231f20; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 8.0pt;">Coagulation profile should be added to routine test that the diabetics undertake to check parameters that are deficient or abnormally produce which could contribute to hypercoagulation so that the necessary medication could be given to the patients to correct the abnormality. </span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><span style="color: #231f20; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 8.0pt;">Further study on the various coagulation assays can be carried on the diabetics to find out which of the coagulation factors is abnormally produced or deficient in production. </span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><br />
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</div><div align="center" class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; text-align: center;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">REFERENCES</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Amoah</span></b><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"> A.G.B. (2003). Socio-demographic variations in obesity among Ghanaian adults. <span style="mso-bidi-font-style: italic;">Public<i> </i>Health<i> </i>Nutr<i>.</i></span>; 6: 751–757. [Medline]</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Amoah</span></b><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"> A.G.B., Owusu S.K, Adjei S. (2002). Diabetes in Ghana: a community based prevalence study in Greater Accra. <span style="mso-bidi-font-style: italic;">Diabetes Res Clin Pract</span> (56): 197–205.</span><span style="mso-spacerun: yes;"><span style="font-family: Calibri;"> </span></span><a href="http://circ.ahajournals.org/cgi/external_ref?access_num=11947967&link_type=MED"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB; text-decoration: none; text-underline: none;">[Medline]</span></a><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"> </span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Amoah</span></b><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"> A.G., Owusu S.K., Schuster D.P., Osei K. (2002). Pathogenic mechanism of type 2 diabetes in Ghanaians: the importance of beta cell secretion, insulin sensitivity and glucose effectiveness. <span style="mso-bidi-font-style: italic;">S Afr Med J. </span>(92): 377–384. </span><a href="http://circ.ahajournals.org/cgi/external_ref?access_num=12108171&link_type=MED"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB; text-decoration: none; text-underline: none;">[Medline]</span></a><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"> </span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">Angiolillo</span></b><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;"> D.J. (2009). antiplatelet therapy in diabetes: efficacy and limitations of current treatment strategies and future directions. Diabetes care (32): 531 – 540.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">Angilolillo</span></b><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;"> D.J., Fermamdez – Ortiz A., Bernardo E. (2005). Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment. 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</div><div align="center" class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: center;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 11.0pt;">APPENDICE I</span></b></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 11.0pt;">LABORATORY TEST PROCEDURE FOR CLOTTING TIME AND PLATELET COUNT</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 11.0pt;">Blood (venous) samples were taken from patient into EDTA tubes using the evacuated tube and treated to standard methods for determining platelet count and a plain 12X75 mm glass tube for determining clotting time.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 11.0pt;">Procedure:</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 11.0pt;">The venipuncture site of the of the patient was cleaned with an antiseptic (alcohol) which helps prevent microbial contamination of the specimen and the patient. The tourniquet was applied to the venipuncture site and the vein was anchored below the puncture site. The needle was inserted at an angle 15 to 30 degrees, smoothly and beveled up. The elevated tube was inserted into the venipuncture site and the blood was allowed to flow freely into the tube. The tourniquet was released, tubes were removed and mixed by inversion, and the glass tubes were placed in the water bath immediately. Gauze was placed over the puncture site.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 11.0pt;">Some of the laboratory test conducted on the samples included:</span></div><div class="MsoListParagraph" style="line-height: 200%; margin: 12pt 0in 10pt 0.5in; mso-add-space: auto; mso-list: l2 level1 lfo3; text-align: justify; text-indent: -0.25in;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 11.0pt; mso-fareast-font-family: "Times New Roman";"><span style="mso-list: Ignore;">1.<span style="font: 7pt "Times New Roman";"> </span></span></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 11.0pt;">Clotting time; which provides information on blood clot in a glass tube, measuring the intrinsic system of coagulation in patient using a manual technique.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-bidi-font-size: 11.0pt;">Procedure:</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">Lee – White Method</span></div><div class="MsoListParagraphCxSpFirst" style="line-height: 200%; margin: 0in 0in 0pt 0.5in; mso-list: l0 level1 lfo4; text-align: justify; text-indent: -0.25in;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-fareast-font-family: "Times New Roman";"><span style="mso-list: Ignore;">a.<span style="font: 7pt "Times New Roman";"> </span></span></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">I used the syringe and needle method of clotting blood into 12 X 75mm plain and EDTA tubes. 3mls of venous blood was clotting into three 12 X 75mm plain tube and 1ml into the EDTA tube. </span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 200%; margin: 0in 0in 0pt 0.5in; mso-list: l0 level1 lfo4; text-align: justify; text-indent: -0.25in;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-fareast-font-family: "Times New Roman";"><span style="mso-list: Ignore;">b.<span style="font: 7pt "Times New Roman";"> </span></span></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">A stopwatch was started soon as the blood entered the syringe. The needle was removed from the syringe and each of the three tubes was filled to the 1ml mark.</span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 200%; margin: 0in 0in 0pt 0.5in; mso-list: l0 level1 lfo4; text-align: justify; text-indent: -0.25in;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-fareast-font-family: "Times New Roman";"><span style="mso-list: Ignore;">c.<span style="font: 7pt "Times New Roman";"> </span></span></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">The test tubes were put into the water at 37ºC. After 3 minutes the first tube was removed from the water bath and tilted gently to and angle of 45º to verify whether the blood has clotted. When the blood was not clotted, it was returned to the water bath and examines at 30 seconds intervals to see if it has clotted.</span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 200%; margin: 0in 0in 0pt 0.5in; mso-list: l0 level1 lfo4; text-align: justify; text-indent: -0.25in;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-fareast-font-family: "Times New Roman";"><span style="mso-list: Ignore;">d.<span style="font: 7pt "Times New Roman";"> </span></span></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">The tube was tilted through an angle of 90º without the content spilling. As soon as the blood was clotted, the second and third tube was examined immediately. </span></div><div class="MsoListParagraphCxSpLast" style="line-height: 200%; margin: 0in 0in 10pt 0.5in; mso-list: l0 level1 lfo4; text-align: justify; text-indent: -0.25in;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-fareast-font-family: "Times New Roman";"><span style="mso-list: Ignore;">e.<span style="font: 7pt "Times New Roman";"> </span></span></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">The stopwatch was stopped and the time taken from the three tubes. The average time was calculated and it indicates the coagulation time (Lewis <i style="mso-bidi-font-style: normal;">et al</i>, 2006).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><br />
</div><div class="MsoListParagraph" style="line-height: 200%; margin: 12pt 0in 10pt 0.5in; mso-add-space: auto; mso-list: l2 level1 lfo3; text-align: justify; text-indent: -0.25in;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-fareast-font-family: "Times New Roman";"><span style="mso-list: Ignore;">2.<span style="font: 7pt "Times New Roman";"> </span></span></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">Platelet Count with the use of an improved Haussser Neubauer ruled Bright – line counting chamber. These chambers are the finest quality, optically ground, and polished milled glass chambers available. The chamber is diamond etched and has a double improved Neubauer Ruling, which has a worldwide reputation in hospitals an laboratories for unmatched reliability, meeting the most demanding of standards. The standard Hausser blood counting chambers are one piece construction (measuring 75mmX32mmX4.5mm) ensuring long term durability and absolute accuracy in measurement and count.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">Reagents and equipment:</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">Ammonium oxalate 10g/l diluting fluid, Neubauer Counting Chamber, microscope, tubes (glass tubes).</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">Procedure:</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">Platelet count would be done within two hours of collection of blood.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 12pt 0in 10pt; text-align: justify;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">0.38ml of filtered ammonium oxalate dilution of blood.</span></div><div class="MsoListParagraphCxSpFirst" style="line-height: 200%; margin: 12pt 0in 0pt 0.5in; mso-add-space: auto; mso-list: l1 level1 lfo5; text-align: justify; text-indent: -0.25in;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-fareast-font-family: "Times New Roman";"><span style="mso-list: Ignore;">1.<span style="font: 7pt "Times New Roman";"> </span></span></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">0.38ml of filtered ammonium oxalate diluting fluid was obtained and dispensed into a small container or tube.</span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 200%; margin: 12pt 0in 0pt 0.5in; mso-add-space: auto; mso-list: l1 level1 lfo5; text-align: justify; text-indent: -0.25in;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-fareast-font-family: "Times New Roman";"><span style="mso-list: Ignore;">2.<span style="font: 7pt "Times New Roman";"> </span></span></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">20 µl of the well – mixed anticoagulanted venous blood was pipette and released into the tube containing the diluting fluid.</span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 200%; margin: 12pt 0in 0pt 0.5in; mso-add-space: auto; mso-list: l1 level1 lfo5; text-align: justify; text-indent: -0.25in;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-fareast-font-family: "Times New Roman";"><span style="mso-list: Ignore;">3.<span style="font: 7pt "Times New Roman";"> </span></span></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;">The chamber was assembled and filled with the well – mixed sample after which it was left undisturbed for 2 minutes. The chamber will be placed in a plastic container on a blotting paper and covered with a lid.</span></div><div class="MsoListParagraphCxSpLast" style="line-height: 200%; margin: 12pt 0in 10pt 0.5in; mso-add-space: auto; mso-list: l1 level1 lfo5; text-align: justify; text-indent: -0.25in;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%; mso-fareast-font-family: "Times New Roman";"><span style="mso-list: Ignore;">4.<span style="font: 7pt "Times New Roman";"> </span></span></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 200%;"><span style="mso-spacerun: yes;"> </span>The underside of the chamber was dried and placed on a microscope stage. Using the 10X objective, the rulings of the grid was focused and the central square of the chamber was brought to view. The objective was changed to the 40X objective and the small platelets were focused. The number of platelets counted was reported in the litres of blood, thus the actual number of platelets counted X10<sup>9</sup>.</span></div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><br />
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</div><div align="center" class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">APPENDIX II: RESULTS</span></b></div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
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<table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-bottom: medium none; border-collapse: collapse; border-left: medium none; border-right: medium none; border-top: medium none; margin: auto auto auto 1.5pt; mso-border-alt: solid black 1.0pt; mso-border-insideh: 1.0pt solid black; mso-border-insidev: 1.0pt solid black; mso-padding-alt: 0in 1.5pt 0in 1.5pt; mso-table-layout-alt: fixed; width: 558px;"><thead>
<tr style="mso-yfti-firstrow: yes; mso-yfti-irow: 0; page-break-inside: avoid;"><td colspan="6" style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: #f0f0f0; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 418.2pt;" width="558"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Table 1: Population Size</span></b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;"></span></div></td></tr>
<tr style="mso-yfti-irow: 1; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.4pt;" valign="top" width="62"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 81.2pt;" valign="top" width="108"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.8pt;" valign="bottom" width="85"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Frequency</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" valign="bottom" width="76"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Percent</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 92.1pt;" valign="bottom" width="123"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Valid Percent</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 78pt;" valign="bottom" width="104"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Cumulative Percent</span></div></td></tr>
<tr style="mso-yfti-irow: 2; page-break-inside: avoid;"><td rowspan="3" style="background: white; border-bottom: #f0f0f0; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.4pt;" valign="top" width="62"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Valid</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 81.2pt;" valign="top" width="108"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Diabetics</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.8pt;" width="85"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">209</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">74.9</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 92.1pt;" width="123"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">75.5</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 78pt;" width="104"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">75.5</span></div></td></tr>
<tr style="mso-yfti-irow: 3; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 81.2pt;" valign="top" width="108"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">non diabetics</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.8pt;" width="85"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">68</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">24.4</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 92.1pt;" width="123"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">24.5</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 78pt;" width="104"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td></tr>
<tr style="mso-yfti-irow: 4; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 81.2pt;" valign="top" width="108"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.8pt;" width="85"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">277</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">99.3</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 92.1pt;" width="123"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 78pt;" valign="top" width="104"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
<tr style="mso-yfti-irow: 5; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.4pt;" valign="top" width="62"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Missing</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 81.2pt;" valign="top" width="108"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">System</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.8pt;" width="85"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.7</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 92.1pt;" valign="top" width="123"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 78pt;" valign="top" width="104"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
</thead><tbody>
<tr style="mso-yfti-irow: 6; mso-yfti-lastrow: yes; page-break-inside: avoid;"><td colspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 127.6pt;" valign="top" width="170"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.8pt;" width="85"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">279</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 92.1pt;" valign="top" width="123"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 78pt;" valign="top" width="104"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
</tbody></table><br />
<div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><br />
<table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-bottom: medium none; border-collapse: collapse; border-left: medium none; border-right: medium none; border-top: medium none; margin: auto auto auto 1.5pt; mso-border-alt: solid black 1.0pt; mso-border-insideh: 1.0pt solid black; mso-border-insidev: 1.0pt solid black; mso-padding-alt: 0in 1.5pt 0in 1.5pt; mso-table-layout-alt: fixed; width: 462px;"><thead>
<tr style="mso-yfti-firstrow: yes; mso-yfti-irow: 0; page-break-inside: avoid;"><td colspan="6" style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: #f0f0f0; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 346.5pt;" width="462"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Table 2: Sex of Diabetics</span></b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;"></span></div></td></tr>
<tr style="mso-yfti-irow: 1; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 0.5in;" valign="top" width="48"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 45.65pt;" valign="top" width="61"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 66.85pt;" valign="bottom" width="89"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Frequency</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.5pt;" valign="bottom" width="66"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Percent</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 76.5pt;" valign="bottom" width="102"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Valid Percent</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" valign="bottom" width="96"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Cumulative Percent</span></div></td></tr>
<tr style="mso-yfti-irow: 2; page-break-inside: avoid;"><td rowspan="3" style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 0.5in;" valign="top" width="48"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Valid</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 45.65pt;" valign="top" width="61"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Male</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 66.85pt;" width="89"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">51</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.5pt;" width="66"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">24.4</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 76.5pt;" width="102"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">24.4</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" width="96"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">24.4</span></div></td></tr>
<tr style="mso-yfti-irow: 3; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 45.65pt;" valign="top" width="61"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Female</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 66.85pt;" width="89"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">158</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.5pt;" width="66"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">75.6</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 76.5pt;" width="102"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">75.6</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" width="96"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td></tr>
</thead><tbody>
<tr style="mso-yfti-irow: 4; mso-yfti-lastrow: yes; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 45.65pt;" valign="top" width="61"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 66.85pt;" width="89"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">209</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.5pt;" width="66"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 76.5pt;" width="102"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" valign="top" width="96"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
</tbody></table><br />
<div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><br />
<table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-bottom: medium none; border-collapse: collapse; border-left: medium none; border-right: medium none; border-top: medium none; margin: auto auto auto 1.5pt; mso-border-alt: solid black 1.0pt; mso-border-insideh: 1.0pt solid black; mso-border-insidev: 1.0pt solid black; mso-padding-alt: 0in 1.5pt 0in 1.5pt; mso-table-layout-alt: fixed; width: 482px;"><thead>
<tr style="mso-yfti-firstrow: yes; mso-yfti-irow: 0; page-break-inside: avoid;"><td colspan="6" style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: #f0f0f0; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 361.5pt;" width="482"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Table 3: Age Groups for Diabetics</span></b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;"></span></div></td></tr>
<tr style="height: 35.6pt; mso-yfti-irow: 1; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: black 2.25pt solid; height: 35.6pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 0.5in;" valign="top" width="48"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; height: 35.6pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.25pt;" valign="top" width="84"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 35.6pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.8pt;" valign="bottom" width="85"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Frequency</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 35.6pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" valign="bottom" width="76"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Percent</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 35.6pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.85pt;" valign="bottom" width="94"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Valid Percent</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; height: 35.6pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.9pt;" valign="bottom" width="95"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Cumulative Percent</span></div></td></tr>
<tr style="mso-yfti-irow: 2; page-break-inside: avoid;"><td rowspan="7" style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 0.5in;" valign="top" width="48"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Valid</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.25pt;" valign="top" width="84"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">below 35</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.8pt;" width="85"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">10</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">4.8</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.85pt;" width="94"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">4.8</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.9pt;" width="95"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">4.8</span></div></td></tr>
<tr style="mso-yfti-irow: 3; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.25pt;" valign="top" width="84"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">35 to 45</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.8pt;" width="85"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">23</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">11.0</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.85pt;" width="94"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">11.0</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.9pt;" width="95"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">15.8</span></div></td></tr>
<tr style="mso-yfti-irow: 4; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.25pt;" valign="top" width="84"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">46 to 55</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.8pt;" width="85"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">62</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">29.7</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.85pt;" width="94"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">29.7</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.9pt;" width="95"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">45.5</span></div></td></tr>
<tr style="mso-yfti-irow: 5; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.25pt;" valign="top" width="84"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">56 to 65</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.8pt;" width="85"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">70</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">33.5</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.85pt;" width="94"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">33.5</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.9pt;" width="95"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">78.9</span></div></td></tr>
<tr style="mso-yfti-irow: 6; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.25pt;" valign="top" width="84"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">66 to 75</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.8pt;" width="85"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">36</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">17.2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.85pt;" width="94"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">17.2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.9pt;" width="95"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">96.2</span></div></td></tr>
<tr style="mso-yfti-irow: 7; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.25pt;" valign="top" width="84"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">above 75</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.8pt;" width="85"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">8</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">3.8</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.85pt;" width="94"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">3.8</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.9pt;" width="95"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td></tr>
</thead><tbody>
<tr style="height: 3.45pt; mso-yfti-irow: 8; mso-yfti-lastrow: yes; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 3.45pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.25pt;" valign="top" width="84"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 3.45pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.8pt;" width="85"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">209</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 3.45pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 3.45pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.85pt;" width="94"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 3.45pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.9pt;" valign="top" width="95"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
</tbody></table><br />
<div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><br />
<table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-bottom: medium none; border-collapse: collapse; border-left: medium none; border-right: medium none; border-top: medium none; margin: auto auto auto 1.5pt; mso-border-alt: solid black 1.0pt; mso-border-insideh: 1.0pt solid black; mso-border-insidev: 1.0pt solid black; mso-padding-alt: 0in 1.5pt 0in 1.5pt; mso-table-layout-alt: fixed; width: 505px;"><thead>
<tr style="mso-yfti-firstrow: yes; mso-yfti-irow: 0; page-break-inside: avoid;"><td colspan="6" style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: #f0f0f0; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 378.5pt;" width="505"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><br />
</div><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Table 4: Category of Clotting for Diabetics</span></b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;"></span></div></td></tr>
<tr style="mso-yfti-irow: 1; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 0.5in;" valign="top" width="48"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 95.15pt;" valign="top" width="127"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 57.1pt;" valign="bottom" width="76"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Frequency</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" valign="bottom" width="67"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Percent</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 68.35pt;" valign="bottom" width="91"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Valid Percent</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" valign="bottom" width="96"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Cumulative Percent</span></div></td></tr>
<tr style="mso-yfti-irow: 2; page-break-inside: avoid;"><td rowspan="3" style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 0.5in;" valign="top" width="48"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Valid</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 95.15pt;" valign="top" width="127"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Lesser than normal</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 57.1pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">13</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">6.2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 68.35pt;" width="91"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">6.2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" width="96"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">6.2</span></div></td></tr>
<tr style="mso-yfti-irow: 3; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 95.15pt;" valign="top" width="127"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Normal</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 57.1pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">196</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">93.8</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 68.35pt;" width="91"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">93.8</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" width="96"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td></tr>
</thead><tbody>
<tr style="mso-yfti-irow: 4; mso-yfti-lastrow: yes; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 95.15pt;" valign="top" width="127"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 57.1pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">209</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 68.35pt;" width="91"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" valign="top" width="96"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
</tbody></table><br />
<div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><br />
<table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-bottom: medium none; border-collapse: collapse; border-left: medium none; border-right: medium none; border-top: medium none; margin: auto auto auto 1.5pt; mso-border-alt: solid black 1.0pt; mso-border-insideh: 1.0pt solid black; mso-border-insidev: 1.0pt solid black; mso-padding-alt: 0in 1.5pt 0in 1.5pt; mso-table-layout-alt: fixed; width: 522px;"><thead>
<tr style="mso-yfti-firstrow: yes; mso-yfti-irow: 0; page-break-inside: avoid;"><td colspan="6" style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: #f0f0f0; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 391.5pt;" width="522"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Table 5: Category of Platelet for Diabetics</span></b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;"></span></div></td></tr>
<tr style="mso-yfti-irow: 1; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 0.5in;" valign="top" width="48"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 85.5pt;" valign="top" width="114"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63pt;" valign="bottom" width="84"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Frequency</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.5pt;" valign="bottom" width="66"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Percent</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" valign="bottom" width="96"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Valid Percent</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 85.5pt;" valign="bottom" width="114"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Cumulative Percent</span></div></td></tr>
<tr style="mso-yfti-irow: 2; page-break-inside: avoid;"><td rowspan="4" style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 0.5in;" valign="top" width="48"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Valid</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 85.5pt;" valign="top" width="114"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Thrombopenia</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63pt;" width="84"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">31</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.5pt;" width="66"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">14.8</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" width="96"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">14.8</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 85.5pt;" width="114"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">14.8</span></div></td></tr>
<tr style="mso-yfti-irow: 3; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 85.5pt;" valign="top" width="114"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Normal</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63pt;" width="84"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">174</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.5pt;" width="66"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">83.3</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" width="96"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">83.3</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 85.5pt;" width="114"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">98.1</span></div></td></tr>
<tr style="mso-yfti-irow: 4; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 85.5pt;" valign="top" width="114"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Thrombosis</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63pt;" width="84"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">4</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.5pt;" width="66"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.9</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" width="96"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.9</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 85.5pt;" width="114"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td></tr>
</thead><tbody>
<tr style="mso-yfti-irow: 5; mso-yfti-lastrow: yes; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 85.5pt;" valign="top" width="114"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63pt;" width="84"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">209</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.5pt;" width="66"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" width="96"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 85.5pt;" valign="top" width="114"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
</tbody></table><br />
<div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><br />
<table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-bottom: medium none; border-collapse: collapse; border-left: medium none; border-right: medium none; border-top: medium none; margin: auto auto auto 1.5pt; mso-border-alt: solid black 1.0pt; mso-border-insideh: 1.0pt solid black; mso-border-insidev: 1.0pt solid black; mso-padding-alt: 0in 1.5pt 0in 1.5pt; mso-table-layout-alt: fixed; width: 522px;"><thead>
<tr style="mso-yfti-firstrow: yes; mso-yfti-irow: 0; page-break-inside: avoid;"><td colspan="6" style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: #f0f0f0; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 391.5pt;" width="522"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Table 6: Category of FBS for Diabetics</span></b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;"></span></div></td></tr>
<tr style="mso-yfti-irow: 1; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 0.5in;" valign="top" width="48"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 85.5pt;" valign="top" width="114"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63pt;" valign="bottom" width="84"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Frequency</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 0.75in;" valign="bottom" width="72"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Percent</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 76.5pt;" valign="bottom" width="102"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Valid Percent</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 76.5pt;" valign="bottom" width="102"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Cumulative Percent</span></div></td></tr>
<tr style="mso-yfti-irow: 2; page-break-inside: avoid;"><td rowspan="4" style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 0.5in;" valign="top" width="48"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Valid</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 85.5pt;" valign="top" width="114"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Hypoglycemia</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63pt;" width="84"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">5</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 0.75in;" width="72"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2.4</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 76.5pt;" width="102"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2.4</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 76.5pt;" width="102"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2.4</span></div></td></tr>
<tr style="mso-yfti-irow: 3; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 85.5pt;" valign="top" width="114"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Normal</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63pt;" width="84"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">78</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 0.75in;" width="72"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">37.3</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 76.5pt;" width="102"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">37.3</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 76.5pt;" width="102"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">39.7</span></div></td></tr>
<tr style="mso-yfti-irow: 4; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 85.5pt;" valign="top" width="114"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Hyperglycemia</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63pt;" width="84"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">126</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 0.75in;" width="72"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">60.3</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 76.5pt;" width="102"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">60.3</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 76.5pt;" width="102"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td></tr>
</thead><tbody>
<tr style="mso-yfti-irow: 5; mso-yfti-lastrow: yes; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 85.5pt;" valign="top" width="114"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63pt;" width="84"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">209</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 0.75in;" width="72"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 76.5pt;" width="102"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 76.5pt;" valign="top" width="102"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
</tbody></table><br />
<div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><br />
<table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-bottom: medium none; border-collapse: collapse; border-left: medium none; border-right: medium none; border-top: medium none; margin: auto auto auto 1.5pt; mso-border-alt: solid black 1.0pt; mso-border-insideh: 1.0pt solid black; mso-border-insidev: 1.0pt solid black; mso-padding-alt: 0in 1.5pt 0in 1.5pt; mso-table-layout-alt: fixed; width: 556px;"><thead>
<tr style="mso-yfti-firstrow: yes; mso-yfti-irow: 0; page-break-inside: avoid;"><td colspan="6" style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: #f0f0f0; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 417.35pt;" width="556"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: center;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: center;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: center;"><b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Table</span></b><b><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;"> 7: Statistics of Non – Diabetics </span></b><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;"></span></div></td></tr>
<tr style="mso-yfti-irow: 1; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 39.45pt;" valign="top" width="53"><div class="MsoNormal" style="margin: 0in 0in 10pt;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 77.35pt;" valign="top" width="103"><div class="MsoNormal" style="margin: 0in 0in 10pt;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.5pt;" valign="bottom" width="85"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: center;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Age Group</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 78.95pt;" valign="bottom" width="105"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: center;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Sex of control subject</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79.05pt;" valign="bottom" width="105"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: center;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Category of clotting time</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79.05pt;" valign="bottom" width="105"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: center;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Category of platelets</span></div></td></tr>
<tr style="mso-yfti-irow: 2; page-break-inside: avoid;"><td rowspan="2" style="background: white; border-bottom: #f0f0f0; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 39.45pt;" valign="top" width="53"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">N</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 77.35pt;" valign="top" width="103"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Valid</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.5pt;" width="85"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">68</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 78.95pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">68</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79.05pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">68</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79.05pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">68</span></div></td></tr>
<tr style="mso-yfti-irow: 3; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 77.35pt;" valign="top" width="103"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Missing</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.5pt;" width="85"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">0</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 78.95pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">0</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79.05pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">0</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79.05pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">0</span></div></td></tr>
<tr style="mso-yfti-irow: 4; page-break-inside: avoid;"><td colspan="2" style="background: white; border-bottom: #f0f0f0; border-left: black 2.25pt solid; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 116.8pt;" valign="top" width="156"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Mean</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.5pt;" width="85"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">1.78</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 78.95pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">1.62</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79.05pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">2.00</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79.05pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">2.16</span></div></td></tr>
<tr style="mso-yfti-irow: 5; page-break-inside: avoid;"><td colspan="2" style="background: white; border-bottom: #f0f0f0; border-left: black 2.25pt solid; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 116.8pt;" valign="top" width="156"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Median</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.5pt;" width="85"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">1.00</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 78.95pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">2.00</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79.05pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">2.00</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79.05pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">2.00</span></div></td></tr>
<tr style="height: 23.25pt; mso-yfti-irow: 6; page-break-inside: avoid;"><td colspan="2" style="background: white; border-bottom: #f0f0f0; border-left: black 2.25pt solid; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 23.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 116.8pt;" valign="top" width="156"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Mode</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 23.25pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.5pt;" width="85"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">1</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 23.25pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 78.95pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 23.25pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79.05pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 23.25pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79.05pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">2</span></div></td></tr>
</thead><tbody>
<tr style="height: 11.55pt; mso-yfti-irow: 7; mso-yfti-lastrow: yes; page-break-inside: avoid;"><td colspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 11.55pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 116.8pt;" valign="top" width="156"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Std. Deviation</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 11.55pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.5pt;" width="85"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">1.325</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 11.55pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 78.95pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">.490</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 11.55pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79.05pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">.000</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 11.55pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79.05pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">.371</span></div></td></tr>
</tbody></table><br />
<div class="MsoNormal" style="margin: 0in 0in 10pt;"><br />
</div><div class="MsoNormal" style="margin: 0in 0in 10pt;"><br />
</div><br />
<table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-bottom: medium none; border-collapse: collapse; border-left: medium none; border-right: medium none; border-top: medium none; margin: auto auto auto 1.5pt; mso-border-alt: solid black 1.0pt; mso-border-insideh: 1.0pt solid black; mso-border-insidev: 1.0pt solid black; mso-padding-alt: 0in 1.5pt 0in 1.5pt; mso-table-layout-alt: fixed; width: 490px;"><thead>
<tr style="mso-yfti-firstrow: yes; mso-yfti-irow: 0; page-break-inside: avoid;"><td colspan="6" style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: #f0f0f0; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 367.6pt;" width="490"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: center;"><b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Table</span></b><b><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;"> 8: Age Group of non – Diabetics</span></b><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;"></span></div></td></tr>
<tr style="height: 35.7pt; mso-yfti-irow: 1; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: black 2.25pt solid; height: 35.7pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 39.5pt;" valign="top" width="53"><div class="MsoNormal" style="margin: 0in 0in 10pt;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; height: 35.7pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" valign="top" width="76"><div class="MsoNormal" style="margin: 0in 0in 10pt;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 35.7pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.65pt;" valign="bottom" width="84"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: center;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Frequency</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 35.7pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 54.75pt;" valign="bottom" width="73"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: center;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Percent</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 35.7pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 75pt;" valign="bottom" width="100"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: center;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Valid Percent</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; height: 35.7pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79pt;" valign="bottom" width="105"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: center;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Cumulative Percent</span></div></td></tr>
<tr style="mso-yfti-irow: 2; page-break-inside: avoid;"><td rowspan="7" style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 39.5pt;" valign="top" width="53"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Valid</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" valign="top" width="76"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">below 35</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.65pt;" width="84"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">41</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 54.75pt;" width="73"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">60.3</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 75pt;" width="100"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">60.3</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">60.3</span></div></td></tr>
<tr style="mso-yfti-irow: 3; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" valign="top" width="76"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">35 to 45</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.65pt;" width="84"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">17</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 54.75pt;" width="73"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">25.0</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 75pt;" width="100"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">25.0</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">85.3</span></div></td></tr>
<tr style="mso-yfti-irow: 4; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" valign="top" width="76"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">46 to 55</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.65pt;" width="84"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 54.75pt;" width="73"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">2.9</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 75pt;" width="100"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">2.9</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">88.2</span></div></td></tr>
<tr style="mso-yfti-irow: 5; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" valign="top" width="76"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">56 to 65</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.65pt;" width="84"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">3</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 54.75pt;" width="73"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">4.4</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 75pt;" width="100"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">4.4</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">92.6</span></div></td></tr>
<tr style="height: 20.45pt; mso-yfti-irow: 6; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 20.45pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" valign="top" width="76"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">66 to 75</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.45pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.65pt;" width="84"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.45pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 54.75pt;" width="73"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">2.9</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.45pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 75pt;" width="100"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">2.9</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 20.45pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">95.6</span></div></td></tr>
<tr style="height: 18.05pt; mso-yfti-irow: 7; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 18.05pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" valign="top" width="76"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">above 75</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 18.05pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.65pt;" width="84"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">3</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 18.05pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 54.75pt;" width="73"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">4.4</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 18.05pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 75pt;" width="100"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">4.4</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 18.05pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td></tr>
</thead><tbody>
<tr style="height: 15.65pt; mso-yfti-irow: 8; mso-yfti-lastrow: yes; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 15.65pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" valign="top" width="76"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 15.65pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.65pt;" width="84"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">68</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 15.65pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 54.75pt;" width="73"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 15.65pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 75pt;" width="100"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 15.65pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79pt;" valign="top" width="105"><div class="MsoNormal" style="margin: 0in 0in 10pt;"><br />
</div></td></tr>
</tbody></table><br />
<div class="MsoNormal" style="margin: 0in 0in 10pt;"><br />
</div><br />
<table align="left" border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-bottom: medium none; border-collapse: collapse; border-left: medium none; border-right: medium none; border-top: medium none; margin: auto 6.75pt; mso-border-alt: solid black 1.0pt; mso-border-insideh: 1.0pt solid black; mso-border-insidev: 1.0pt solid black; mso-padding-alt: 0in 1.5pt 0in 1.5pt; mso-table-anchor-horizontal: margin; mso-table-anchor-vertical: paragraph; mso-table-layout-alt: fixed; mso-table-left: left; mso-table-lspace: 9.0pt; mso-table-rspace: 9.0pt; mso-table-top: 19.7pt; width: 477px;"><thead>
<tr style="mso-yfti-firstrow: yes; mso-yfti-irow: 0; page-break-inside: avoid;"><td colspan="6" style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: #f0f0f0; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 357.9pt;" width="477"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: center;"><b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Table</span></b><b><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;"> 9: Sex of non – Diabetics</span></b><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;"></span></div></td></tr>
<tr style="mso-yfti-irow: 1; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 39.45pt;" valign="top" width="53"><div class="MsoNormal" style="margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.85pt;" valign="top" width="62"><div class="MsoNormal" style="margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.7pt;" valign="bottom" width="84"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: center;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Frequency</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 54.8pt;" valign="bottom" width="73"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: center;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Percent</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 75.05pt;" valign="bottom" width="100"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: center;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Valid Percent</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79.05pt;" valign="bottom" width="105"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: center;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Cumulative Percent</span></div></td></tr>
<tr style="mso-yfti-irow: 2; page-break-inside: avoid;"><td rowspan="3" style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 39.45pt;" valign="top" width="53"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Valid</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.85pt;" valign="top" width="62"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">male</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.7pt;" width="84"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">26</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 54.8pt;" width="73"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">38.2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 75.05pt;" width="100"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">38.2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79.05pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">38.2</span></div></td></tr>
<tr style="mso-yfti-irow: 3; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.85pt;" valign="top" width="62"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">female</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.7pt;" width="84"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">42</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 54.8pt;" width="73"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">61.8</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 75.05pt;" width="100"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">61.8</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79.05pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td></tr>
</thead><tbody>
<tr style="height: 41.9pt; mso-yfti-irow: 4; mso-yfti-lastrow: yes; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 41.9pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.85pt;" valign="top" width="62"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 41.9pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.7pt;" width="84"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">68</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 41.9pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 54.8pt;" width="73"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 41.9pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 75.05pt;" width="100"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 41.9pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79.05pt;" valign="top" width="105"><div class="MsoNormal" style="margin: 0in 0in 10pt; mso-element-anchor-horizontal: margin; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 19.7pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly;"><br />
</div></td></tr>
</tbody></table><br />
<div class="MsoNormal" style="margin: 0in 0in 10pt;"><br />
</div><div class="MsoNormal" style="margin: 0in 0in 10pt;"><br />
</div><div class="MsoNormal" style="margin: 0in 0in 10pt;"><br />
</div><br />
<table align="left" border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-bottom: medium none; border-collapse: collapse; border-left: medium none; border-right: medium none; border-top: medium none; margin: auto 6.75pt; mso-border-alt: solid black 1.0pt; mso-border-insideh: 1.0pt solid black; mso-border-insidev: 1.0pt solid black; mso-padding-alt: 0in 1.5pt 0in 1.5pt; mso-table-anchor-horizontal: column; mso-table-anchor-vertical: paragraph; mso-table-layout-alt: fixed; mso-table-left: left; mso-table-lspace: 9.0pt; mso-table-overlap: never; mso-table-rspace: 9.0pt; mso-table-top: 29.35pt; width: 474px;"><thead>
<tr style="height: 17.4pt; mso-yfti-firstrow: yes; mso-yfti-irow: 0; page-break-inside: avoid;"><td colspan="6" style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: #f0f0f0; border-top: #f0f0f0; height: 17.4pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 355.5pt;" width="474"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: column; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 29.35pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly;"><br />
</div><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: column; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 29.35pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly;"><br />
</div><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: column; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 29.35pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly;"><br />
</div><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: column; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 29.35pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: column; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 29.35pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: center;"><b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Table</span></b><b><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;"> 10: Category of clotting time for non – Diabetics</span></b><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;"></span></div></td></tr>
<tr style="height: 1.75pt; mso-yfti-irow: 1; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: black 2.25pt solid; height: 1.75pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 39.45pt;" valign="top" width="53"><div class="MsoNormal" style="margin: 0in 0in 10pt; mso-element-anchor-horizontal: column; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 29.35pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; height: 1.75pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.35pt;" valign="top" width="66"><div class="MsoNormal" style="margin: 0in 0in 10pt; mso-element-anchor-horizontal: column; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 29.35pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 1.75pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.7pt;" valign="bottom" width="84"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: column; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 29.35pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: center;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Frequency</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 1.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 54.8pt;" valign="bottom" width="73"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: column; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 29.35pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: center;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Percent</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 1.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 75.05pt;" valign="bottom" width="100"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: column; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 29.35pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: center;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Valid Percent</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; height: 1.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 74.15pt;" valign="bottom" width="99"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: column; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 29.35pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: center;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Cumulative Percent</span></div></td></tr>
</thead><tbody>
<tr style="mso-yfti-irow: 2; mso-yfti-lastrow: yes; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 39.45pt;" valign="top" width="53"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: column; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 29.35pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Valid</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.35pt;" valign="top" width="66"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: column; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 29.35pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Normal</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.7pt;" width="84"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: column; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 29.35pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">68</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 54.8pt;" width="73"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: column; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 29.35pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 75.05pt;" width="100"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: column; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 29.35pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 74.15pt;" width="99"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; mso-element-anchor-horizontal: column; mso-element-anchor-vertical: paragraph; mso-element-frame-hspace: 9.0pt; mso-element-top: 29.35pt; mso-element-wrap: around; mso-element: frame; mso-height-rule: exactly; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td></tr>
</tbody></table><br />
<div class="MsoNormal" style="margin: 0in 0in 10pt;"><span style="font-size: 12pt; line-height: 115%;"><br clear="all" style="mso-special-character: line-break;" /></span></div><br />
<table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-bottom: medium none; border-collapse: collapse; border-left: medium none; border-right: medium none; border-top: medium none; margin: auto auto auto 1.5pt; mso-border-alt: solid black 1.0pt; mso-border-insideh: 1.0pt solid black; mso-border-insidev: 1.0pt solid black; mso-padding-alt: 0in 1.5pt 0in 1.5pt; mso-table-layout-alt: fixed; width: 508px;"><thead>
<tr style="height: 47.1pt; mso-yfti-firstrow: yes; mso-yfti-irow: 0; page-break-inside: avoid;"><td colspan="6" style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: #f0f0f0; border-top: #f0f0f0; height: 47.1pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 381.3pt;" width="508"><div align="center" class="MsoNormal" style="margin: 0in 0in 10pt; text-align: center;"><b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%;">Table</span></b><b><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%;"> 11: Category of platelets for non – Diabetics</span></b><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%;"></span></div></td></tr>
<tr style="mso-yfti-irow: 1; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 39.45pt;" valign="top" width="53"><div class="MsoNormal" style="margin: 0in 0in 10pt;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.75pt;" valign="top" width="94"><div class="MsoNormal" style="margin: 0in 0in 10pt;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.7pt;" valign="bottom" width="84"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: center;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Frequency</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 54.8pt;" valign="bottom" width="73"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: center;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Percent</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 74.55pt;" valign="bottom" width="99"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: center;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Valid Percent</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79.05pt;" valign="bottom" width="105"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: center;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Cumulative Percent</span></div></td></tr>
<tr style="mso-yfti-irow: 2; page-break-inside: avoid;"><td rowspan="3" style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 39.45pt;" valign="top" width="53"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Valid</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.75pt;" valign="top" width="94"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Normal</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.7pt;" width="84"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">57</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 54.8pt;" width="73"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">83.8</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 74.55pt;" width="99"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">83.8</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79.05pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">83.8</span></div></td></tr>
<tr style="mso-yfti-irow: 3; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.75pt;" valign="top" width="94"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Thrombosis</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.7pt;" width="84"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">11</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 54.8pt;" width="73"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">16.2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 74.55pt;" width="99"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">16.2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79.05pt;" width="105"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td></tr>
</thead><tbody>
<tr style="mso-yfti-irow: 4; mso-yfti-lastrow: yes; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.75pt;" valign="top" width="94"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.7pt;" width="84"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">68</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 54.8pt;" width="73"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 74.55pt;" width="99"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 10pt; text-align: right;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">100.0</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 79.05pt;" valign="top" width="105"><div class="MsoNormal" style="margin: 0in 0in 10pt;"><br />
</div></td></tr>
</tbody></table><br />
<div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><br />
<table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-bottom: medium none; border-collapse: collapse; border-left: medium none; border-right: medium none; border-top: medium none; margin: auto auto auto -5.6pt; mso-border-alt: solid black 1.0pt; mso-border-insideh: 1.0pt solid black; mso-border-insidev: 1.0pt solid black; mso-padding-alt: 0in 1.5pt 0in 1.5pt; mso-table-layout-alt: fixed; width: 662px;"><thead>
<tr style="height: 19.1pt; mso-yfti-firstrow: yes; mso-yfti-irow: 0; page-break-inside: avoid;"><td colspan="10" style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: #f0f0f0; border-top: #f0f0f0; height: 19.1pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 496.15pt;" width="662"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Table 12a: Descriptive of the population subjects</span></b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;"></span></div></td></tr>
<tr style="height: 37.25pt; mso-yfti-irow: 1; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: black 2.25pt solid; height: 37.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.4pt;" valign="top" width="65"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; height: 37.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 81.9pt;" valign="top" width="109"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 37.25pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 34.4pt;" valign="bottom" width="46"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">N</span></div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 37.25pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 40.1pt;" valign="bottom" width="53"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Mean</span></div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 37.25pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51.7pt;" valign="bottom" width="69"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Std. Deviation</span></div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 37.25pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 41.2pt;" valign="bottom" width="55"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Std. Error</span></div></td><td colspan="2" style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 37.25pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 85.05pt;" valign="bottom" width="113"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">95% Confidence Interval for Mean</span></div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 37.25pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" valign="bottom" width="76"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Minimum</span></div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; height: 37.25pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" valign="bottom" width="76"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Maximum</span></div></td></tr>
<tr style="height: 37.25pt; mso-yfti-irow: 2; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; height: 37.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.4pt;" valign="top" width="65"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 37.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 81.9pt;" valign="top" width="109"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 37.25pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.55pt;" valign="bottom" width="57"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Lower Bound</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 37.25pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.5pt;" valign="bottom" width="57"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Upper Bound</span></div></td></tr>
<tr style="height: 20.2pt; mso-yfti-irow: 3; page-break-inside: avoid;"><td rowspan="3" style="background: white; border-bottom: black 1pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; height: 20.2pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.4pt;" valign="top" width="65"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">platelets level</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 20.2pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 81.9pt;" valign="top" width="109"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Diabetics</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.2pt; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 34.4pt;" width="46"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">209</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.2pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 40.1pt;" width="53"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">232.52</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.2pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51.7pt;" width="69"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">88.197</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.2pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 41.2pt;" width="55"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">6.101</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.2pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.55pt;" width="57"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">220.49</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.2pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.5pt;" width="57"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">244.54</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.2pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">49</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 20.2pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">743</span></div></td></tr>
<tr style="height: 8.2pt; mso-yfti-irow: 4; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8.2pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 81.9pt;" valign="top" width="109"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">non diabetics</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 34.4pt;" width="46"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">68</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 40.1pt;" width="53"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">297.19</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51.7pt;" width="69"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">99.414</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 41.2pt;" width="55"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">12.056</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.55pt;" width="57"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">273.13</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.5pt;" width="57"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">321.25</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">151</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">586</span></div></td></tr>
<tr style="height: 8.2pt; mso-yfti-irow: 5; page-break-inside: avoid;"><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8.2pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 81.9pt;" valign="top" width="109"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 34.4pt;" width="46"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">277</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 40.1pt;" width="53"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">248.39</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51.7pt;" width="69"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">95.074</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 41.2pt;" width="55"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">5.712</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.55pt;" width="57"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">237.15</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.5pt;" width="57"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">259.64</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">49</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">743</span></div></td></tr>
<tr style="height: 20.2pt; mso-yfti-irow: 6; page-break-inside: avoid;"><td rowspan="3" style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; height: 20.2pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.4pt;" valign="top" width="65"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">clotting time</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 20.2pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 81.9pt;" valign="top" width="109"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Diabetics</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.2pt; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 34.4pt;" width="46"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">209</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.2pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 40.1pt;" width="53"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.3100</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.2pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51.7pt;" width="69"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.61318</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.2pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 41.2pt;" width="55"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.11159</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.2pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.55pt;" width="57"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.0901</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.2pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.5pt;" width="57"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.5300</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.2pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">3.56</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 20.2pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">11.18</span></div></td></tr>
<tr style="height: 8.2pt; mso-yfti-irow: 7; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8.2pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 81.9pt;" valign="top" width="109"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">non diabetics</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 34.4pt;" width="46"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">68</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 40.1pt;" width="53"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">9.3050</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51.7pt;" width="69"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.33110</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 41.2pt;" width="55"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.16142</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.55pt;" width="57"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">8.9828</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.5pt;" width="57"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">9.6272</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">6.33</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">12.45</span></div></td></tr>
</thead><tbody>
<tr style="height: 8.2pt; mso-yfti-irow: 8; mso-yfti-lastrow: yes; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8.2pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 81.9pt;" valign="top" width="109"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 34.4pt;" width="46"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">277</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 40.1pt;" width="53"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.7998</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51.7pt;" width="69"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.76950</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 41.2pt;" width="55"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.10632</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.55pt;" width="57"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.5905</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.5pt;" width="57"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">8.0091</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">3.56</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8.2pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">12.45</span></div></td></tr>
</tbody></table><br />
<div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><br />
<table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-bottom: medium none; border-collapse: collapse; border-left: medium none; border-right: medium none; border-top: medium none; margin: auto auto auto 1.5pt; mso-border-alt: solid black 1.0pt; mso-border-insideh: 1.0pt solid black; mso-border-insidev: 1.0pt solid black; mso-padding-alt: 0in 1.5pt 0in 1.5pt; mso-table-layout-alt: fixed; width: 593px;"><thead>
<tr style="mso-yfti-firstrow: yes; mso-yfti-irow: 0; page-break-inside: avoid;"><td colspan="7" style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: #f0f0f0; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 444.6pt;" width="593"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Table 12b: ANOVA between the Diabetics and Non – diabetics</span></b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;"></span></div></td></tr>
<tr style="mso-yfti-irow: 1; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.4pt;" valign="top" width="94"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.2pt;" valign="top" width="111"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" valign="bottom" width="96"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Sum of Squares</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" valign="bottom" width="67"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">df</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" valign="bottom" width="92"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Mean Square</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="bottom" width="67"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">F</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="bottom" width="67"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Sig.</span></div></td></tr>
<tr style="mso-yfti-irow: 2; page-break-inside: avoid;"><td rowspan="3" style="background: white; border-bottom: black 1pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.4pt;" valign="top" width="94"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">platelets level</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.2pt;" valign="top" width="111"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Between Groups</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" width="96"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">214605.402</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" width="92"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">214605.402</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">25.883</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.000</span></div></td></tr>
<tr style="mso-yfti-irow: 3; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.2pt;" valign="top" width="111"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Within Groups</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" width="96"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2280154.706</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">275</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" width="92"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">8291.472</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
<tr style="mso-yfti-irow: 4; page-break-inside: avoid;"><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.2pt;" valign="top" width="111"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" width="96"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2494760.108</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">276</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" valign="top" width="92"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
<tr style="mso-yfti-irow: 5; page-break-inside: avoid;"><td rowspan="3" style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 70.4pt;" valign="top" width="94"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">clotting time</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.2pt;" valign="top" width="111"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Between Groups</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" width="96"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">204.193</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" width="92"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">204.193</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">85.080</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.000</span></div></td></tr>
<tr style="mso-yfti-irow: 6; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.2pt;" valign="top" width="111"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Within Groups</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" width="96"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">660.004</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">275</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" width="92"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2.400</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
</thead><tbody>
<tr style="mso-yfti-irow: 7; mso-yfti-lastrow: yes; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.2pt;" valign="top" width="111"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" width="96"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">864.197</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">276</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" valign="top" width="92"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
</tbody></table><br />
<div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><br />
<table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-bottom: medium none; border-collapse: collapse; border-left: medium none; border-right: medium none; border-top: medium none; margin: auto auto auto 1.5pt; mso-border-alt: solid black 1.0pt; mso-border-insideh: 1.0pt solid black; mso-border-insidev: 1.0pt solid black; mso-padding-alt: 0in 1.5pt 0in 1.5pt; mso-table-layout-alt: fixed; width: 658px;"><thead>
<tr style="height: 18.4pt; mso-yfti-firstrow: yes; mso-yfti-irow: 0; page-break-inside: avoid;"><td colspan="10" style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: #f0f0f0; border-top: #f0f0f0; height: 18.4pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 493.55pt;" width="658"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Table 13a: <span style="mso-spacerun: yes;"> </span>Descriptives of the sexes in the populated sample</span></b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;"></span></div></td></tr>
<tr style="height: 19.4pt; mso-yfti-irow: 1; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: black 2.25pt solid; height: 19.4pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 47.25pt;" valign="top" width="63"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; height: 19.4pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 36.15pt;" valign="top" width="48"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 19.4pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 34.75pt;" valign="bottom" width="46"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">N</span></div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 19.4pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51.95pt;" valign="bottom" width="69"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Mean</span></div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 19.4pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 52.3pt;" valign="bottom" width="70"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Std. Deviation</span></div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 19.4pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.7pt;" valign="bottom" width="65"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Std. Error</span></div></td><td colspan="2" style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 19.4pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 125.1pt;" valign="bottom" width="167"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">95% Confidence Interval for Mean</span></div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 19.4pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.65pt;" valign="bottom" width="65"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Minimum</span></div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; height: 19.4pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.7pt;" valign="bottom" width="65"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Maximum</span></div></td></tr>
<tr style="height: 18.4pt; mso-yfti-irow: 2; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; height: 18.4pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 47.25pt;" valign="top" width="63"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 18.4pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 36.15pt;" valign="top" width="48"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 18.4pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.5pt;" valign="bottom" width="83"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Lower Bound</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 18.4pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.6pt;" valign="bottom" width="83"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Upper Bound</span></div></td></tr>
<tr style="height: 20.5pt; mso-yfti-irow: 3; page-break-inside: avoid;"><td rowspan="3" style="background: white; border-bottom: black 1pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; height: 20.5pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 47.25pt;" valign="top" width="63"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Platelets</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 20.5pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 36.15pt;" valign="top" width="48"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">male</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.5pt; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 34.75pt;" width="46"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">51</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.5pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51.95pt;" width="69"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2.2657E2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.5pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 52.3pt;" width="70"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">125.33096</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.5pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.7pt;" width="65"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">17.54985</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.5pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.5pt;" width="83"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">191.3187</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.5pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.6pt;" width="83"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">261.8185</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 20.5pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.65pt;" width="65"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">63.00</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 20.5pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.7pt;" width="65"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">743.00</span></div></td></tr>
<tr style="height: 8.3pt; mso-yfti-irow: 4; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8.3pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 36.15pt;" valign="top" width="48"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">female</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 34.75pt;" width="46"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">158</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51.95pt;" width="69"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2.3444E2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 52.3pt;" width="70"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">72.71815</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.7pt;" width="65"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">5.78515</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.5pt;" width="83"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">223.0100</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.6pt;" width="83"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">245.8635</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.65pt;" width="65"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">49.00</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.7pt;" width="65"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">434.00</span></div></td></tr>
<tr style="height: 8.3pt; mso-yfti-irow: 5; page-break-inside: avoid;"><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8.3pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 36.15pt;" valign="top" width="48"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 34.75pt;" width="46"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">209</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51.95pt;" width="69"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2.3252E2</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 52.3pt;" width="70"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">88.19734</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.7pt;" width="65"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">6.10074</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.5pt;" width="83"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">220.4895</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.6pt;" width="83"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">244.5440</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.65pt;" width="65"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">49.00</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.7pt;" width="65"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">743.00</span></div></td></tr>
<tr style="height: 19.4pt; mso-yfti-irow: 6; page-break-inside: avoid;"><td rowspan="3" style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; height: 19.4pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 47.25pt;" valign="top" width="63"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Clotting time</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 19.4pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 36.15pt;" valign="top" width="48"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">male</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.4pt; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 34.75pt;" width="46"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">51</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.4pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51.95pt;" width="69"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">6.9367</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.4pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 52.3pt;" width="70"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.69374</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.4pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.7pt;" width="65"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.23717</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.4pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.5pt;" width="83"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">6.4603</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.4pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.6pt;" width="83"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.4130</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.4pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.65pt;" width="65"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">4.06</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 19.4pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.7pt;" width="65"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">11.00</span></div></td></tr>
<tr style="height: 8.3pt; mso-yfti-irow: 7; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8.3pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 36.15pt;" valign="top" width="48"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">female</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 34.75pt;" width="46"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">158</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51.95pt;" width="69"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.4306</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 52.3pt;" width="70"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.57296</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.7pt;" width="65"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.12514</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.5pt;" width="83"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.1834</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.6pt;" width="83"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.6777</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.65pt;" width="65"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">3.56</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.7pt;" width="65"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">11.18</span></div></td></tr>
</thead><tbody>
<tr style="height: 8.3pt; mso-yfti-irow: 8; mso-yfti-lastrow: yes; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8.3pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 36.15pt;" valign="top" width="48"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 34.75pt;" width="46"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">209</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51.95pt;" width="69"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.3100</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 52.3pt;" width="70"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.61318</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.7pt;" width="65"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.11159</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.5pt;" width="83"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.0901</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 62.6pt;" width="83"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.5300</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.65pt;" width="65"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">3.56</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8.3pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 48.7pt;" width="65"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">11.18</span></div></td></tr>
</tbody></table><br />
<div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><br />
<table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-bottom: medium none; border-collapse: collapse; border-left: medium none; border-right: medium none; border-top: medium none; margin: auto auto auto 1.5pt; mso-border-alt: solid black 1.0pt; mso-border-insideh: 1.0pt solid black; mso-border-insidev: 1.0pt solid black; mso-padding-alt: 0in 1.5pt 0in 1.5pt; mso-table-layout-alt: fixed; width: 587px;"><thead>
<tr style="mso-yfti-firstrow: yes; mso-yfti-irow: 0; page-break-inside: avoid;"><td colspan="7" style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: #f0f0f0; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 440.1pt;" width="587"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Table 13b: ANOVA between diabetics males and females</span></b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;"></span></div></td></tr>
<tr style="mso-yfti-irow: 1; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 65.9pt;" valign="top" width="88"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.2pt;" valign="top" width="111"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" valign="bottom" width="96"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Sum of Squares</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" valign="bottom" width="67"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">df</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" valign="bottom" width="92"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Mean Square</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="bottom" width="67"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">F</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="bottom" width="67"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Sig.</span></div></td></tr>
<tr style="mso-yfti-irow: 2; page-break-inside: avoid;"><td rowspan="3" style="background: white; border-bottom: black 1pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 65.9pt;" valign="top" width="88"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Platelets</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.2pt;" valign="top" width="111"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Between Groups</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" width="96"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2386.814</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" width="92"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2386.814</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.306</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.581</span></div></td></tr>
<tr style="mso-yfti-irow: 3; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.2pt;" valign="top" width="111"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Within Groups</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" width="96"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1615597.377</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">207</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" width="92"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7804.818</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
<tr style="mso-yfti-irow: 4; page-break-inside: avoid;"><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.2pt;" valign="top" width="111"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" width="96"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1617984.191</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">208</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" valign="top" width="92"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
<tr style="mso-yfti-irow: 5; page-break-inside: avoid;"><td rowspan="3" style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 65.9pt;" valign="top" width="88"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Clotting time</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.2pt;" valign="top" width="111"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Between Groups</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" width="96"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">9.405</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" width="92"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">9.405</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">3.660</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.057</span></div></td></tr>
<tr style="mso-yfti-irow: 6; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.2pt;" valign="top" width="111"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Within Groups</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" width="96"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">531.886</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">207</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" width="92"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2.569</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
</thead><tbody>
<tr style="mso-yfti-irow: 7; mso-yfti-lastrow: yes; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.2pt;" valign="top" width="111"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 1in;" width="96"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">541.291</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">208</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" valign="top" width="92"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
</tbody></table><br />
<div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><br />
<table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-bottom: medium none; border-collapse: collapse; border-left: medium none; border-right: medium none; border-top: medium none; margin: auto auto auto -12.7pt; mso-border-alt: solid black 1.0pt; mso-border-insideh: 1.0pt solid black; mso-border-insidev: 1.0pt solid black; mso-padding-alt: 0in 1.5pt 0in 1.5pt; mso-table-layout-alt: fixed; width: 653px;"><thead>
<tr style="height: 17.2pt; mso-yfti-firstrow: yes; mso-yfti-irow: 0; page-break-inside: avoid;"><td colspan="10" style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: #f0f0f0; border-top: #f0f0f0; height: 17.2pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 489.75pt;" width="653"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Table 14a: Descriptives of the age groups of the populated sample</span></b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;"></span></div></td></tr>
<tr style="height: 18.15pt; mso-yfti-irow: 1; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: black 2.25pt solid; height: 18.15pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.7pt;" valign="top" width="72"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; height: 18.15pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.2pt;" valign="top" width="62"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 18.15pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 33.25pt;" valign="bottom" width="44"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">N</span></div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 18.15pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" valign="bottom" width="71"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Mean</span></div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 18.15pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" valign="bottom" width="71"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Std. Deviation</span></div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 18.15pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" valign="bottom" width="71"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Std. Error</span></div></td><td colspan="2" style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 18.15pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 104.2pt;" valign="bottom" width="139"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">95% Confidence Interval for Mean</span></div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 18.15pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 45.8pt;" valign="bottom" width="61"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Minimum</span></div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; height: 18.15pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 47pt;" valign="bottom" width="63"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Maximum</span></div></td></tr>
<tr style="height: 18.15pt; mso-yfti-irow: 2; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; height: 18.15pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.7pt;" valign="top" width="72"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 18.15pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.2pt;" valign="top" width="62"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 18.15pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" valign="bottom" width="71"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Lower Bound</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 18.15pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51pt;" valign="bottom" width="68"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Upper Bound</span></div></td></tr>
<tr style="height: 19.1pt; mso-yfti-irow: 3; page-break-inside: avoid;"><td rowspan="7" style="background: white; border-bottom: black 1pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; height: 19.1pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.7pt;" valign="top" width="72"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Platelets</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 19.1pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.2pt;" valign="top" width="62"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Below 35</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.1pt; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 33.25pt;" width="44"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">10</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.1pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2.3030E2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.1pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">57.51145</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.1pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">18.18672</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.1pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">189.1588</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.1pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51pt;" width="68"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">271.4412</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.1pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 45.8pt;" width="61"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">115.00</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 19.1pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 47pt;" width="63"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">304.00</span></div></td></tr>
<tr style="height: 7.75pt; mso-yfti-irow: 4; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 7.75pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.2pt;" valign="top" width="62"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">35-45</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 33.25pt;" width="44"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">23</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2.1683E2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">66.13392</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">13.78988</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">188.2276</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51pt;" width="68"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">245.4245</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 45.8pt;" width="61"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">61.00</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 47pt;" width="63"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">351.00</span></div></td></tr>
<tr style="height: 7.75pt; mso-yfti-irow: 5; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 7.75pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.2pt;" valign="top" width="62"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">46-55</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 33.25pt;" width="44"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">62</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2.4524E2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">119.93478</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">15.23173</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">214.7842</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51pt;" width="68"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">275.6997</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 45.8pt;" width="61"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">49.00</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 47pt;" width="63"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">743.00</span></div></td></tr>
<tr style="height: 7.75pt; mso-yfti-irow: 6; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 7.75pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.2pt;" valign="top" width="62"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">56-65</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 33.25pt;" width="44"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">70</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2.3476E2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">74.27864</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">8.87800</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">217.0460</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51pt;" width="68"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">252.4683</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 45.8pt;" width="61"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">78.00</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 47pt;" width="63"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">412.00</span></div></td></tr>
<tr style="height: 7.75pt; mso-yfti-irow: 7; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 7.75pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.2pt;" valign="top" width="62"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">66-75</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 33.25pt;" width="44"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">36</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2.2350E2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">72.37620</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">12.06270</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">199.0114</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51pt;" width="68"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">247.9886</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 45.8pt;" width="61"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">59.00</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 47pt;" width="63"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">384.00</span></div></td></tr>
<tr style="height: 7.75pt; mso-yfti-irow: 8; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 7.75pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.2pt;" valign="top" width="62"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Above 75</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 33.25pt;" width="44"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">8</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2.0275E2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">59.03449</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">20.87185</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">153.3959</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51pt;" width="68"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">252.1041</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 45.8pt;" width="61"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">135.00</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 47pt;" width="63"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">284.00</span></div></td></tr>
<tr style="height: 7.75pt; mso-yfti-irow: 9; page-break-inside: avoid;"><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 7.75pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.2pt;" valign="top" width="62"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 33.25pt;" width="44"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">209</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2.3252E2</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">88.19734</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">6.10074</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">220.4895</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51pt;" width="68"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">244.5440</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 45.8pt;" width="61"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">49.00</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 47pt;" width="63"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">743.00</span></div></td></tr>
<tr style="height: 18.15pt; mso-yfti-irow: 10; page-break-inside: avoid;"><td rowspan="7" style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; height: 18.15pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.7pt;" valign="top" width="72"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Clotting time</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 18.15pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.2pt;" valign="top" width="62"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Below 35</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 18.15pt; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 33.25pt;" width="44"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">10</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 18.15pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.4480</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 18.15pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.30633</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 18.15pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.41310</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 18.15pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">6.5135</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 18.15pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51pt;" width="68"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">8.3825</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 18.15pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 45.8pt;" width="61"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">6.06</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 18.15pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 47pt;" width="63"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">10.18</span></div></td></tr>
<tr style="height: 7.75pt; mso-yfti-irow: 11; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 7.75pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.2pt;" valign="top" width="62"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">35-45</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 33.25pt;" width="44"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">23</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.5796</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.58122</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.32971</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">6.8958</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51pt;" width="68"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">8.2633</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 45.8pt;" width="61"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">4.31</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 47pt;" width="63"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">10.56</span></div></td></tr>
<tr style="height: 7.75pt; mso-yfti-irow: 12; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 7.75pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.2pt;" valign="top" width="62"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">46-55</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 33.25pt;" width="44"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">62</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.0465</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.55974</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.19809</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">6.6504</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51pt;" width="68"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.4426</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 45.8pt;" width="61"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">3.56</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 47pt;" width="63"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">9.47</span></div></td></tr>
<tr style="height: 7.75pt; mso-yfti-irow: 13; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 7.75pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.2pt;" valign="top" width="62"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">56-65</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 33.25pt;" width="44"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">70</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.5611</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.59827</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.19103</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.1800</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51pt;" width="68"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.9422</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 45.8pt;" width="61"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">4.05</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 47pt;" width="63"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">11.18</span></div></td></tr>
<tr style="height: 7.75pt; mso-yfti-irow: 14; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 7.75pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.2pt;" valign="top" width="62"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">66-75</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 33.25pt;" width="44"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">36</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.1197</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.77850</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.29642</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">6.5180</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51pt;" width="68"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.7215</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 45.8pt;" width="61"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">4.06</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 47pt;" width="63"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">10.41</span></div></td></tr>
<tr style="height: 7.75pt; mso-yfti-irow: 15; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 7.75pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.2pt;" valign="top" width="62"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Above 75</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 33.25pt;" width="44"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">8</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.0650</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.82027</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.64356</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">5.5432</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51pt;" width="68"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">8.5868</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 45.8pt;" width="61"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">4.20</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 7.75pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 47pt;" width="63"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">10.14</span></div></td></tr>
</thead><tbody>
<tr style="height: 10.35pt; mso-yfti-irow: 16; mso-yfti-lastrow: yes; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 10.35pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 46.2pt;" valign="top" width="62"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 10.35pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 33.25pt;" width="44"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">209</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 10.35pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.3100</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 10.35pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.61318</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 10.35pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.11159</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 10.35pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 53.2pt;" width="71"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.0901</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 10.35pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 51pt;" width="68"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7.5300</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 10.35pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 45.8pt;" width="61"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">3.56</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 10.35pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 47pt;" width="63"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">11.18</span></div></td></tr>
</tbody></table><br />
<div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><br />
<table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-bottom: medium none; border-collapse: collapse; border-left: medium none; border-right: medium none; border-top: medium none; margin: auto auto auto 1.5pt; mso-border-alt: solid black 1.0pt; mso-border-insideh: 1.0pt solid black; mso-border-insidev: 1.0pt solid black; mso-padding-alt: 0in 1.5pt 0in 1.5pt; mso-table-layout-alt: fixed; width: 587px;"><thead>
<tr style="mso-yfti-firstrow: yes; mso-yfti-irow: 0; page-break-inside: avoid;"><td colspan="7" style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: #f0f0f0; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 440.25pt;" width="587"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Table 14b: ANOVA among the age groups</span></b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;"></span></div></td></tr>
<tr style="mso-yfti-irow: 1; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 65.95pt;" valign="top" width="88"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.3pt;" valign="top" width="111"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 77.55pt;" valign="bottom" width="103"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Sum of Squares</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 44.35pt;" valign="bottom" width="59"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">df</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" valign="bottom" width="92"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Mean Square</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="bottom" width="67"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">F</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="bottom" width="67"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Sig.</span></div></td></tr>
<tr style="mso-yfti-irow: 2; page-break-inside: avoid;"><td rowspan="3" style="background: white; border-bottom: black 1pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 65.95pt;" valign="top" width="88"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Platelets</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.3pt;" valign="top" width="111"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Between Groups</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 77.55pt;" width="103"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">26118.045</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 44.35pt;" width="59"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">5</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" width="92"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">5223.609</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.666</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.650</span></div></td></tr>
<tr style="mso-yfti-irow: 3; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.3pt;" valign="top" width="111"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Within Groups</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 77.55pt;" width="103"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1591866.147</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 44.35pt;" width="59"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">203</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" width="92"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">7841.705</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
<tr style="mso-yfti-irow: 4; page-break-inside: avoid;"><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.3pt;" valign="top" width="111"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 77.55pt;" width="103"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1617984.191</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 44.35pt;" width="59"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">208</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" valign="top" width="92"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
<tr style="mso-yfti-irow: 5; page-break-inside: avoid;"><td rowspan="3" style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 65.95pt;" valign="top" width="88"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Clotting time</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.3pt;" valign="top" width="111"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Between Groups</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 77.55pt;" width="103"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">12.367</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 44.35pt;" width="59"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">5</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" width="92"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2.473</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.949</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.450</span></div></td></tr>
<tr style="mso-yfti-irow: 6; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.3pt;" valign="top" width="111"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Within Groups</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 77.55pt;" width="103"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">528.924</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 44.35pt;" width="59"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">203</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" width="92"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2.606</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
</thead><tbody>
<tr style="mso-yfti-irow: 7; mso-yfti-lastrow: yes; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.3pt;" valign="top" width="111"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 77.55pt;" width="103"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">541.291</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 44.35pt;" width="59"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">208</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" valign="top" width="92"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
</tbody></table><br />
<div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><br />
<table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-bottom: medium none; border-collapse: collapse; border-left: medium none; border-right: medium none; border-top: medium none; margin: auto auto auto 1.5pt; mso-border-alt: solid black 1.0pt; mso-border-insideh: 1.0pt solid black; mso-border-insidev: 1.0pt solid black; mso-padding-alt: 0in 1.5pt 0in 1.5pt; mso-table-layout-alt: fixed; width: 601px;"><thead>
<tr style="mso-yfti-firstrow: yes; mso-yfti-irow: 0; page-break-inside: avoid;"><td colspan="7" style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: #f0f0f0; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 450.75pt;" width="601"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><b><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">Table 15: ANOVA among the sugar level in diabetics</span></b><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;"></span></div></td></tr>
<tr style="mso-yfti-irow: 1; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 76.5pt;" valign="top" width="102"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 72.35pt;" valign="top" width="96"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 82.9pt;" valign="bottom" width="111"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">Sum of Squares</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" valign="bottom" width="67"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">df</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" valign="bottom" width="92"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">Mean Square</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="bottom" width="67"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">F</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="bottom" width="67"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">Sig.</span></div></td></tr>
<tr style="mso-yfti-irow: 2; page-break-inside: avoid;"><td rowspan="3" style="background: white; border-bottom: black 1pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 76.5pt;" valign="top" width="102"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">Clotting Time</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 72.35pt;" valign="top" width="96"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">Between Groups</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 82.9pt;" width="111"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">3.735</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" width="92"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">1.868</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">.716</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">.490</span></div></td></tr>
<tr style="mso-yfti-irow: 3; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 72.35pt;" valign="top" width="96"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">Within Groups</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 82.9pt;" width="111"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">537.556</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">206</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" width="92"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">2.609</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
<tr style="mso-yfti-irow: 4; page-break-inside: avoid;"><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 72.35pt;" valign="top" width="96"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 82.9pt;" width="111"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">541.291</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">208</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" valign="top" width="92"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
<tr style="mso-yfti-irow: 5; page-break-inside: avoid;"><td rowspan="3" style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 76.5pt;" valign="top" width="102"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">Platelet (x10^9)</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 72.35pt;" valign="top" width="96"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">Between Groups</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 82.9pt;" width="111"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">9520.847</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">2</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" width="92"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">4760.424</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">.610</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">.545</span></div></td></tr>
<tr style="mso-yfti-irow: 6; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 72.35pt;" valign="top" width="96"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">Within Groups</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 82.9pt;" width="111"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">1608463.344</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">206</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" width="92"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">7808.074</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
</thead><tbody>
<tr style="mso-yfti-irow: 7; mso-yfti-lastrow: yes; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 72.35pt;" valign="top" width="96"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 82.9pt;" width="111"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">1617984.191</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.9pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Arial", "sans-serif"; font-size: 12pt;">208</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.1pt;" valign="top" width="92"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
</tbody></table><br />
<div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><br />
<table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-bottom: medium none; border-collapse: collapse; border-left: medium none; border-right: medium none; border-top: medium none; margin: auto auto auto 1.5pt; mso-border-alt: solid black 1.0pt; mso-border-insideh: 1.0pt solid black; mso-border-insidev: 1.0pt solid black; mso-padding-alt: 0in 1.5pt 0in 1.5pt; mso-table-layout-alt: fixed; width: 652px;"><thead>
<tr style="height: 17.55pt; mso-yfti-firstrow: yes; mso-yfti-irow: 0; page-break-inside: avoid;"><td colspan="10" style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: #f0f0f0; border-top: #f0f0f0; height: 17.55pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 489.05pt;" width="652"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><br />
</div><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Table 16a: Descriptives between the males and female Clotting Time and platelet Count</span></b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;"></span></div></td></tr>
<tr style="height: 18.6pt; mso-yfti-irow: 1; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: black 2.25pt solid; height: 18.6pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.8pt;" valign="top" width="85"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; height: 18.6pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.55pt;" valign="top" width="57"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 18.6pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 35.4pt;" valign="bottom" width="47"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">N</span></div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 18.6pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.55pt;" valign="bottom" width="57"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Mean</span></div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 18.6pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" valign="bottom" width="76"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Std. Deviation</span></div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 18.6pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 35.45pt;" valign="bottom" width="47"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Std. Error</span></div></td><td colspan="2" style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 18.6pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 99.2pt;" valign="bottom" width="132"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">95% Confidence Interval for Mean</span></div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; height: 18.6pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" valign="bottom" width="76"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Minimum</span></div></td><td rowspan="2" style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; height: 18.6pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" valign="bottom" width="76"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Maximum</span></div></td></tr>
<tr style="height: 17.55pt; mso-yfti-irow: 2; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; height: 17.55pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.8pt;" valign="top" width="85"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 17.55pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.55pt;" valign="top" width="57"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 17.55pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.6pt;" valign="bottom" width="66"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Lower Bound</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 17.55pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.6pt;" valign="bottom" width="66"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Upper Bound</span></div></td></tr>
<tr style="height: 19.6pt; mso-yfti-irow: 3; page-break-inside: avoid;"><td rowspan="3" style="background: white; border-bottom: black 1pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; height: 19.6pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.8pt;" valign="top" width="85"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Category of Clotting</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 19.6pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.55pt;" valign="top" width="57"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Male</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.6pt; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 35.4pt;" width="47"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">51</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.6pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.55pt;" width="57"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.90</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.6pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.300</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.6pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 35.45pt;" width="47"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.042</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.6pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.6pt;" width="66"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.82</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.6pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.6pt;" width="66"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.99</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.6pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 19.6pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2</span></div></td></tr>
<tr style="height: 8pt; mso-yfti-irow: 4; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.55pt;" valign="top" width="57"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Female</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 35.4pt;" width="47"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">158</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.55pt;" width="57"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.95</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.220</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 35.45pt;" width="47"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.017</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.6pt;" width="66"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.91</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.6pt;" width="66"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.98</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2</span></div></td></tr>
<tr style="height: 8pt; mso-yfti-irow: 5; page-break-inside: avoid;"><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.55pt;" valign="top" width="57"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 35.4pt;" width="47"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">209</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.55pt;" width="57"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.94</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.242</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 35.45pt;" width="47"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.017</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.6pt;" width="66"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.90</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.6pt;" width="66"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.97</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2</span></div></td></tr>
<tr style="height: 19.6pt; mso-yfti-irow: 6; page-break-inside: avoid;"><td rowspan="3" style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; height: 19.6pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 63.8pt;" valign="top" width="85"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Category of Platelet</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 19.6pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.55pt;" valign="top" width="57"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Male</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.6pt; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 35.4pt;" width="47"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">51</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.6pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.55pt;" width="57"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.80</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.6pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.491</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.6pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 35.45pt;" width="47"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.069</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.6pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.6pt;" width="66"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.67</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.6pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.6pt;" width="66"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.94</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 19.6pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 19.6pt; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">3</span></div></td></tr>
<tr style="height: 8pt; mso-yfti-irow: 7; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.55pt;" valign="top" width="57"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Female</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 35.4pt;" width="47"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">158</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.55pt;" width="57"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.89</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.349</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 35.45pt;" width="47"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.028</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.6pt;" width="66"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.84</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.6pt;" width="66"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.95</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">3</span></div></td></tr>
</thead><tbody>
<tr style="height: 8pt; mso-yfti-irow: 8; mso-yfti-lastrow: yes; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.55pt;" valign="top" width="57"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 35.4pt;" width="47"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">209</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 42.55pt;" width="57"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.87</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.389</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 35.45pt;" width="47"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.027</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.6pt;" width="66"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.82</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 49.6pt;" width="66"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.92</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; height: 8pt; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 56.7pt;" width="76"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">3</span></div></td></tr>
</tbody></table><br />
<div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><br />
<table border="1" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-bottom: medium none; border-collapse: collapse; border-left: medium none; border-right: medium none; border-top: medium none; margin: auto auto auto 1.5pt; mso-border-alt: solid black 1.0pt; mso-border-insideh: 1.0pt solid black; mso-border-insidev: 1.0pt solid black; mso-padding-alt: 0in 1.5pt 0in 1.5pt; mso-table-layout-alt: fixed; width: 629px;"><thead>
<tr style="mso-yfti-firstrow: yes; mso-yfti-irow: 0; page-break-inside: avoid;"><td colspan="7" style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: #f0f0f0; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 471.5pt;" width="629"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Table 18b: ANOVA among the sexes with Diabetes</span></b><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;"></span></div></td></tr>
<tr style="mso-yfti-irow: 1; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 95pt;" valign="top" width="127"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.7pt;" valign="top" width="112"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 72.45pt;" valign="bottom" width="97"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Sum of Squares</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50.2pt;" valign="bottom" width="67"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">df</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.55pt;" valign="bottom" width="93"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Mean Square</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50.3pt;" valign="bottom" width="67"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">F</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: black 2.25pt solid; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50.3pt;" valign="bottom" width="67"><div align="center" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: center;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Sig.</span></div></td></tr>
<tr style="mso-yfti-irow: 2; page-break-inside: avoid;"><td rowspan="3" style="background: white; border-bottom: black 1pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 95pt;" valign="top" width="127"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Category of Clotting</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.7pt;" valign="top" width="112"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Between Groups</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 72.45pt;" width="97"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.087</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50.2pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.55pt;" width="93"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.087</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50.3pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1.482</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50.3pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.225</span></div></td></tr>
<tr style="mso-yfti-irow: 3; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.7pt;" valign="top" width="112"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Within Groups</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 72.45pt;" width="97"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">12.105</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50.2pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">207</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.55pt;" width="93"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.058</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50.3pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50.3pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
<tr style="mso-yfti-irow: 4; page-break-inside: avoid;"><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.7pt;" valign="top" width="112"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 72.45pt;" width="97"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">12.191</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50.2pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">208</span></div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.55pt;" valign="top" width="93"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50.3pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 1pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50.3pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
<tr style="mso-yfti-irow: 5; page-break-inside: avoid;"><td rowspan="3" style="background: white; border-bottom: black 2.25pt solid; border-left: black 2.25pt solid; border-right: #f0f0f0; border-top: #f0f0f0; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 95pt;" valign="top" width="127"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Category of Platelet</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.7pt;" valign="top" width="112"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Between Groups</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 72.45pt;" width="97"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.302</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50.2pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">1</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.55pt;" width="93"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.302</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50.3pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">2.002</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; mso-border-top-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50.3pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.159</span></div></td></tr>
<tr style="mso-yfti-irow: 6; page-break-inside: avoid;"><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.7pt;" valign="top" width="112"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Within Groups</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 72.45pt;" width="97"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">31.210</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50.2pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">207</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.55pt;" width="93"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">.151</span></div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50.3pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: #f0f0f0; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50.3pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
</thead><tbody>
<tr style="mso-yfti-irow: 7; mso-yfti-lastrow: yes; page-break-inside: avoid;"><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 83.7pt;" valign="top" width="112"><div class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">Total</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 2.25pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 72.45pt;" width="97"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">31.512</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50.2pt;" width="67"><div align="right" class="MsoNormal" style="line-height: 16pt; margin: 0in 0in 0pt; mso-layout-grid-align: none; text-align: right;"><span style="color: black; font-family: "Times New Roman", "serif"; font-size: 12pt;">208</span></div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 69.55pt;" valign="top" width="93"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 1pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50.3pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td><td style="background: white; border-bottom: black 2.25pt solid; border-left: #f0f0f0; border-right: black 2.25pt solid; border-top: #f0f0f0; mso-border-left-alt: solid black 1.0pt; padding-bottom: 1.5pt; padding-left: 1.5pt; padding-right: 1.5pt; padding-top: 1.5pt; width: 50.3pt;" valign="top" width="67"><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div></td></tr>
</tbody></table><br />
<div class="MsoNormal" style="line-height: 20pt; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: 200%; margin: 0in 0in 10pt; text-align: justify;"><br />
</div></div>Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-3973389828232632821.post-31762017690178043402011-04-19T16:58:00.000-07:002011-04-19T16:58:31.285-07:00HOW TO TAKE CARE OF YOUR HEART IF YOU HAVE HEART FAILURE<div dir="ltr" style="text-align: left;" trbidi="on"><!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves/> <w:TrackFormatting/> <w:PunctuationKerning/> <w:ValidateAgainstSchemas/> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF/> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables/> <w:SnapToGridInCell/> <w:WrapTextWithPunct/> <w:UseAsianBreakRules/> <w:DontGrowAutofit/> <w:SplitPgBreakAndParaMark/> <w:DontVertAlignCellWithSp/> <w:DontBreakConstrainedForcedTables/> <w:DontVertAlignInTxbx/> <w:Word11KerningPairs/> <w:CachedColBalance/> </w:Compatibility> <w:BrowserLevel>MicrosoftInternetExplorer4</w:BrowserLevel> <m:mathPr> <m:mathFont m:val="Cambria Math"/> <m:brkBin m:val="before"/> <m:brkBinSub m:val="--"/> <m:smallFrac m:val="off"/> <m:dispDef/> <m:lMargin m:val="0"/> <m:rMargin m:val="0"/> <m:defJc m:val="centerGroup"/> <m:wrapIndent m:val="1440"/> <m:intLim m:val="subSup"/> <m:naryLim m:val="undOvr"/> </m:mathPr></w:WordDocument> </xml><![endif]--><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true"
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<div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">Taking care of yourself increases your chances of living a long and healthy life. Here is information about ways you can take care of your heart.</span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">Important information for patients with heart failure</span></b></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">Call your doctor if you experience any of the following:</span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">1. Increasing shortness of breath</span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">2. Lack of sleep due to shortness of breath or difficulty breathing</span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">3. Swelling or increased swelling in your legs and feet</span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">4. Fainting or near blackouts</span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">5. Chest discomfort (heart pain) that is more frequent or more severe</span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">If you experience chest discomfort (heart pain) that is not promptly relieved by rest, take nitroglycerin every five minutes for three doses.</span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">If the chest discomfort (heart pain) is not relieved by nitroglycerin or if the chest discomfort lasts longer than 20 minutes, call 911.</span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><b><i><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">You may be having a heart attack.</span></i></b><span style="font-family: "Times New Roman","serif"; font-size: 12pt;"></span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">What is heart failure?</span></b></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">Heart failure occurs when your heart is not able to pump as much blood as your body needs. This inability to pump enough blood may be caused by heart muscle weakness or stiffness or by a “bad” valve. No matter what caused your heart failure, there are things you can do to increase the chances that you will live a long and healthy life.</span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">What can I do to increase my chances of living a long and healthy life?</span></b></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">Follow your doctor’s recommendations and use this checklist to set goals and make changes in your life. Keep your goals simple and realistic to help you reach them.</span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">Salt, alcohol, and tobacco</span></b></div><div class="MsoListParagraphCxSpFirst" style="line-height: normal; margin-bottom: 0.0001pt; text-indent: -0.25in;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;"><span>1.<span style="font: 7pt "Times New Roman";"> </span></span></span><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">Reduce your salt intake. Avoid table salt and prepared foods. Do not use a salt substitute unless you discuss it with your doctor first. Follow any low salt diet instructions from your doctor. </span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: normal; margin-bottom: 0.0001pt; text-indent: -0.25in;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;"><span>2.<span style="font: 7pt "Times New Roman";"> </span></span></span><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">Limit the amount of alcohol you drink. Women should consume no more than one drink a day; men should consume no more than two drinks a day. </span></div><div class="MsoListParagraphCxSpLast" style="line-height: normal; margin-bottom: 0.0001pt; text-indent: -0.25in;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;"><span>3.<span style="font: 7pt "Times New Roman";"> </span></span></span><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">Avoid using tobacco products such as cigarettes and chewing tobacco.</span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">Exercise and weight</span></b><span style="font-family: "Times New Roman","serif"; font-size: 12pt;"></span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;"><span> </span>1. Follow your doctor’s exercise recommendations. </span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;"><span> </span></span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;"><span> </span>2. Weigh yourself daily after urinating and before eating breakfast. Record your weight in a <span> </span></span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;"><span> </span><span> </span>diary or on a calendar. If you gain weight unexpectedly over several days or weeks, <span> </span></span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;"><span> </span>contact the doctor treating you for heart failure.</span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">Medications</span></b></div><div class="MsoListParagraphCxSpFirst" style="line-height: normal; margin-bottom: 0.0001pt; text-indent: -0.25in;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;"><span>1.<span style="font: 7pt "Times New Roman";"> </span></span></span><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">Take your medications as directed. Notify your doctor if you can’t afford your medications. </span></div><div class="MsoListParagraphCxSpLast" style="line-height: normal; margin-bottom: 0.0001pt; text-indent: -0.25in;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;"><span>2.<span style="font: 7pt "Times New Roman";"> </span></span></span><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">Review your medications each time you visit the doctor’s office (take your pill bottles). Some medications can be harmful for patients with heart failure. Check with your doctor’s office before taking over-the-counter medications or medications for pain or arthritis. Tylenol or generic acetaminophen is okay.</span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><b><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">Follow-up</span></b></div><div class="MsoListParagraphCxSpFirst" style="line-height: normal; margin-bottom: 0.0001pt; text-indent: -0.25in;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;"><span>1.<span style="font: 7pt "Times New Roman";"> </span></span></span><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">Stay in touch with your doctor’s office. Keep your follow-up appointments; they are important opportunities for your doctor to evaluate your health. </span></div><div class="MsoListParagraphCxSpLast" style="line-height: normal; margin-bottom: 0.0001pt; text-indent: -0.25in;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;"><span>2.<span style="font: 7pt "Times New Roman";"> </span></span></span><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">Complete your Medic Alert form and have “Heart Failure” imprinted on the back of your identification bracelet. Your Medic Alert identification informs healthcare providers about your condition.</span></div></div>Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-3973389828232632821.post-42908674657623688442011-04-10T05:45:00.000-07:002011-04-10T05:48:15.627-07:00ARKADMEDLAB: BLOOD FILM FOR MALARIA PARASITES<div dir="ltr" style="text-align: left;" trbidi="on"><a href="http://arkadmedlab.blogspot.com/2011/04/blood-film-for-malaria-parasites.html">ARKADMEDLAB: BLOOD FILM FOR MALARIA PARASITES</a></div>Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-3973389828232632821.post-38513723335151877202011-04-10T05:37:00.000-07:002011-04-10T05:41:36.964-07:00BLOOD FILM FOR MALARIA PARASITES<div dir="ltr" style="text-align: left;" trbidi="on"><br />
<div align="center" class="MsoNormal" style="text-align: center;"><b>BLOOD FILM FOR MALARIA PARASITES</b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>OBJECTIVES:</b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal">To detect the presence of malaria parasites in blood.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal">Stained thick and films are used to diagnose malaria and other blood parasites.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal">PROCEDURE:</div><div class="MsoNormal"><br />
</div><ol start="1" style="margin-top: 0in;" type="1"><li class="MsoNormal">Place one large drop of well-mixed blood in the center of a clean glass slide.</li>
</ol><div class="MsoNormal" style="margin-left: 0.25in;"><br />
</div><ol start="2" style="margin-top: 0in;" type="1"><li class="MsoNormal">Using the corner of a second slide, carefully spread the drop or the blood over an </li>
</ol><div class="MsoNormal" style="margin-left: 0.25in;"> area of 10-12mm.</div><div class="MsoNormal" style="margin-left: 0.25in;"><br />
</div><ol start="3" style="margin-top: 0in;" type="1"><li class="MsoNormal">To determine the thickness of the film, place the slide on a piece of newspaper. Small print should just be visible through the blood film.</li>
</ol><div class="MsoNormal" style="margin-left: 0.25in;"><br />
</div><ol start="4" style="margin-top: 0in;" type="1"><li class="MsoNormal">Dry the film at room temperature.</li>
</ol><div class="MsoNormal"><br />
</div><ol start="5" style="margin-top: 0in;" type="1"><li class="MsoNormal">Prepare 1 in 10 dilution of the stock Giemsa.</li>
</ol><div class="MsoNormal"><br />
</div><ol start="6" style="margin-top: 0in;" type="1"><li class="MsoNormal">Cover the entire smear with the diluted Giemsa stain and stain for at least 10 minutes.</li>
</ol><div class="MsoNormal"><br />
</div><ol start="7" style="margin-top: 0in;" type="1"><li class="MsoNormal">Wash gently in buffer (7.2) and leave slide top dry in an upright position at room temperature.</li>
</ol><div class="MsoNormal"><br />
</div><ol start="8" style="margin-top: 0in;" type="1"><li class="MsoNormal">Examine under 100 x objective lens for the presence or absence of malaria (BLOOD) parasites.</li>
</ol><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>PRECAUTIONS:</b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal" style="margin-left: 0.5in; text-indent: -0.25in;"><span style="font-family: Wingdings;">v<span style="font: 7pt "Times New Roman";"> </span></span>pH of the Buffer 7.2 must be adhered to.</div><div class="MsoNormal" style="margin-left: 0.25in;"><br />
</div><div class="MsoNormal" style="margin-left: 0.5in; text-indent: -0.25in;"><span style="font-family: Wingdings;">v<span style="font: 7pt "Times New Roman";"> </span></span>Blood smear should not be thick.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal" style="margin-left: 0.5in; text-indent: -0.25in;"><span style="font-family: Wingdings;">v<span style="font: 7pt "Times New Roman";"> </span></span>Stain should be filtered before use.</div><div class="MsoNormal" style="margin-left: 0.25in;"><br />
</div><div class="MsoNormal" style="margin-left: 0.5in; text-indent: -0.25in;"><span style="font-family: Wingdings;">v<span style="font: 7pt "Times New Roman";"> </span></span>Slides must be picked at random for re-examination as a quality control measure by the in-charge.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>BLOOD FILM FOR MALARIA PARASITES (CONTINUATION)</b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b>REPORTING:</b></div><div class="MsoNormal">The system entails using a code of between one and four plus signs as follows:</div><div class="MsoNormal">+ = 1 – 10 Parasites per 100 thick film fields.</div><div class="MsoNormal">++ = 11 – 100 Parasites per 100 thick film fields.</div><div class="MsoNormal">+++ = 1 - 10 Parasites per single thick film fields.</div><div class="MsoNormal">++++ = More than 10 Parasites per single thick film field.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal">All stages of malaria parasites (i.e. Trophozoites, Gametocytes, Pigments and Schizonts) should be reported.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal">Malaria parasites present (+) or Malaria parasites Not Seen.</div></div>Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-3973389828232632821.post-52654613214102282092011-04-08T14:57:00.000-07:002011-04-08T14:57:21.188-07:00Compare the antidepressant MAOIs and SSRIs in terms of pharmacokinetics, pharmacodynamics and mode of action.<div class="MsoListParagraphCxSpFirst" style="line-height: normal; margin: 0in 0in 0pt 0.5in; mso-add-space: auto; mso-layout-grid-align: none; mso-list: l0 level1 lfo1; text-indent: -0.25in;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; mso-fareast-font-family: "Times New Roman";"><span style="mso-list: Ignore;">a.<span style="font: 7pt "Times New Roman";"> </span></span></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">PHARMACOKINETICS</span></div><div class="MsoListParagraphCxSpLast" style="line-height: normal; margin: 0in 0in 0pt 0.5in; mso-add-space: auto; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">The monoamine oxidase inhibitors (MAOIs) are readily absorbed from the gastrointestinal tract.</span></div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">The hydrazide inhibitor phenelzine is acetylated in the liver and manifests differences in elimination depending on the acetylation phenotype of the individual. However, inhibition of MAO persists even after these drugs are no longer detectable in plasma. Therefore, conventional pharmacokinetic parameters (half-life, etc) are not very helpful in governing dosage. It is prudent to assume that the drug effect will persist for from 7 days (tranylcypromine) to 2 or 3 weeks (phenelzine) after discontinuance of the drug whiles the pharmacokinetic parameters of these SSRIs eg. fluoxetine is notable for the long half-life of its active metabolite, norfluoxetine (7–9 days at steady state). This long <i>t </i></span><span style="font-family: "Times New Roman", "serif"; font-size: 8pt;">1/2 </span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">has allowed for the introduction of a formulation for once-weekly dosing. Fluoxetine inhibits various drug-metabolizing enzymes, which has led to a number of significant drug-drug interactions with other antidepressants and with other drugs as well. Sertraline and paroxetine have pharmacokinetic parameters similar to those of tricyclics. Citalopram and fluvoxamine resemble fluoxetine.</span></div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">The most likely pharmacokinetic interactions are between the potent inhibitors of P450 2D6,</span></div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">paroxetine and fluoxetine, and those drugs highly dependent on this pathway for clearance (eg,</span></div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">desipramine, nortriptyline, flecainide. Actual instances of clinically significant interactions are extremely rare, there being only a handful of case reports after cumulative exposure of more than 50 million patients to these SSRI drugs. Inhibition of P450 3A4 could possibly occur at high concentrations of nefazodone and fluvoxamine and block the metabolism of the many substrates of this isoform.</span></div><div class="MsoNormal" style="line-height: normal; margin: 0in 0in 0pt; mso-layout-grid-align: none;"><br />
</div><div class="MsoListParagraphCxSpFirst" style="line-height: normal; margin: 0in 0in 0pt 0.5in; mso-add-space: auto; mso-layout-grid-align: none; mso-list: l0 level1 lfo1; text-indent: -0.25in;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; mso-fareast-font-family: "Times New Roman";"><span style="mso-list: Ignore;">b.<span style="font: 7pt "Times New Roman";"> </span></span></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt;">PHARMACODYNAMICS</span></div><div class="MsoListParagraphCxSpLast" style="line-height: normal; margin: 0in 0in 0pt 0.5in; mso-add-space: auto; mso-layout-grid-align: none;"><br />
</div><div class="MsoNormal" style="margin: 0in 0in 10pt;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%;">MAO inhibitors block a major degradative pathway for the amine neurotransmitters, which permits more amines to accumulate in presynaptic stores and more to be released. Some of the second-generation antidepressants have similar effects on amine neurotransmitters, while others have mild or minimal effects on reuptake or metabolism. In contrast, trazodone, nefazodone, and mirtazapine stand out as agents in which antagonism of subtypes of serotonin receptors (5-HT2A or 5-HT2C) may be important in their action. Mirtazapine is unique in including antagonism of 2 norepinephrine receptors as presumably contributing to its therapeutic effects. Bupropion has been found to alter the output of norepinephrine in humans following chronic administration through some as yet unidentified primary mechanism as well as occupying about 25% of dopamine uptake pumps in the brain as revealed by positron emission tomography. Since it has been shown that effective doses of SSRIs occupy 80% of serotonin uptake sites, the clinical relevance of 25% dopamine uptake occupancy is uncertain. Thus, even the newest antidepressants can still be categorized as working through serotonergic and noradrenergic effects with the possibility of a role for dopamine. A potential dopaminergic mechanism has often been invoked as relevant to the efficacy of MAOIs.</span></div><div class="MsoNormal" style="margin: 0in 0in 10pt;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%;">Many of the pharmacodynamic interactions of antidepressants with other drugs have already been discussed. Sedative effects may be additive with other sedatives, especially alcohol. Patients taking tricyclics should be warned that use of alcohol may lead to greater than expected impairment of driving ability. MAO inhibitors, by increasing stores of catecholamines, sensitize the patient to indirectly acting sympathomimetics such as tyramine, which is found in some fermented foods and beverages, and to sympathomimetic drugs such as diethylpropion, phenylpropanolamine, or botanicals containing ephedrine. Such sensitization can result in dangerous and—rarely—fatal hypertensive reactions. The serious interaction between MAO inhibitors and selective serotonin reuptake inhibitors has been mentioned; the serotonin syndrome is potentially lethal and must be avoided.</span></div><div class="MsoListParagraph" style="margin: 0in 0in 10pt 0.5in; mso-list: l0 level1 lfo1; text-indent: -0.25in;"><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; mso-fareast-font-family: "Times New Roman";"><span style="mso-list: Ignore;">c.<span style="font: 7pt "Times New Roman";"> </span></span></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%;">MODE OF ACTION</span></div><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; mso-ansi-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin;">MAOIs act by inhibiting the activity of </span><span style="font-family: "Calibri", "sans-serif"; font-size: 11pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;"><a href="http://en.wikipedia.org/wiki/Monoamine_oxidase"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; text-decoration: none; text-underline: none;">monoamine oxidase</span></a></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; mso-ansi-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin;">, thus preventing the breakdown of </span><span style="font-family: "Calibri", "sans-serif"; font-size: 11pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;"><a href="http://en.wikipedia.org/wiki/Monoamine_neurotransmitter" title="Monoamine neurotransmitter"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; text-decoration: none; text-underline: none;">monoamine neurotransmitters</span></a></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; mso-ansi-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin;"> and thereby increasing their availability. There are two </span><span style="font-family: "Calibri", "sans-serif"; font-size: 11pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;"><a href="http://en.wikipedia.org/wiki/Isoform" title="Isoform"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; text-decoration: none; text-underline: none;">isoforms</span></a></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; mso-ansi-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin;"> of monoamine oxidase, MAO-A and MAO-B. MAO-A preferentially </span><span style="font-family: "Calibri", "sans-serif"; font-size: 11pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;"><a href="http://en.wikipedia.org/wiki/Deamination" title="Deamination"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; text-decoration: none; text-underline: none;">deaminates</span></a></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; mso-ansi-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin;"> </span><span style="font-family: "Calibri", "sans-serif"; font-size: 11pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;"><a href="http://en.wikipedia.org/wiki/Serotonin"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; text-decoration: none; text-underline: none;">serotonin</span></a></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; mso-ansi-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin;">, </span><span style="font-family: "Calibri", "sans-serif"; font-size: 11pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;"><a href="http://en.wikipedia.org/wiki/Melatonin"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; text-decoration: none; text-underline: none;">melatonin</span></a></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; mso-ansi-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin;">, </span><span style="font-family: "Calibri", "sans-serif"; font-size: 11pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;"><a href="http://en.wikipedia.org/wiki/Epinephrine"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; text-decoration: none; text-underline: none;">epinephrine</span></a></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; mso-ansi-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin;"> and </span><span style="font-family: "Calibri", "sans-serif"; font-size: 11pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;"><a href="http://en.wikipedia.org/wiki/Norepinephrine"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; text-decoration: none; text-underline: none;">norepinephrine</span></a></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; mso-ansi-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin;">. MAO-B preferentially deaminates </span><span style="font-family: "Calibri", "sans-serif"; font-size: 11pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;"><a href="http://en.wikipedia.org/wiki/Phenylethylamine" title="Phenylethylamine"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; text-decoration: none; text-underline: none;">phenylethylamine</span></a></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; mso-ansi-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin;"> and </span><span style="font-family: "Calibri", "sans-serif"; font-size: 11pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;"><a href="http://en.wikipedia.org/wiki/Trace_amine" title="Trace amine"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; text-decoration: none; text-underline: none;">trace amines</span></a></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; mso-ansi-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin;">. </span><span style="font-family: "Calibri", "sans-serif"; font-size: 11pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;"><a href="http://en.wikipedia.org/wiki/Dopamine"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; text-decoration: none; text-underline: none;">Dopamine</span></a></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; mso-ansi-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin;"> is equally deaminated by both types. Many formulations have forms of </span><span style="font-family: "Calibri", "sans-serif"; font-size: 11pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;"><a href="http://en.wikipedia.org/wiki/Fluoride"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; text-decoration: none; text-underline: none;">fluoride</span></a></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; mso-ansi-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin;"> attached to assist in permeating the </span><span style="font-family: "Calibri", "sans-serif"; font-size: 11pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;"><a href="http://en.wikipedia.org/wiki/Blood-brain_barrier"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; text-decoration: none; text-underline: none;">blood-brain barrier</span></a></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; mso-ansi-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin;">, which is suspected as a factor in </span><span style="font-family: "Calibri", "sans-serif"; font-size: 11pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;"><a href="http://en.wikipedia.org/wiki/Pineal_gland"><span style="color: windowtext; font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; text-decoration: none; text-underline: none;">pineal gland</span></a></span><span style="font-family: "Times New Roman", "serif"; font-size: 12pt; line-height: 115%; mso-ansi-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin;"> effects whiles SSRIs act by blocking the reuptake of serotonin in the synaptic cleft thereby increasing the levels of serotonin (increases brain activity).</span>Unknownnoreply@blogger.com0